1.5.1.33: pteridine reductase
This is an abbreviated version!
For detailed information about pteridine reductase, go to the full flat file.
Word Map on EC 1.5.1.33
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1.5.1.33
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leishmania
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dihydrofolate
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trypanosoma
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antileishmanial
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antifolate
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promastigotes
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leishmaniasis
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trypanosomatids
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pterins
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donovani
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amastigotes
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trypanosomiasis
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dhfr-t
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trypanothione
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reductase-thymidylate
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tarentolae
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dihydrobiopterin
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glucantime
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medicine
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drug development
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pharmacology
- 1.5.1.33
- leishmania
- dihydrofolate
- trypanosoma
-
antileishmanial
- antifolate
- promastigotes
- leishmaniasis
-
trypanosomatids
- pterins
- donovani
- amastigotes
- trypanosomiasis
-
dhfr-t
- trypanothione
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reductase-thymidylate
- tarentolae
- dihydrobiopterin
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glucantime
- medicine
- drug development
- pharmacology
Reaction
Synonyms
Atu1130, EC 1.1.1.253, H region methotrexate resistance protein, LaPTR1, LbPTR1, LdPTR1, LmPTR1, LpPTR1, More, NADPH-dependent short-chain dehydrogenase/reductase pteridine reductase, NADPH-dihydropteridine reductase, PruA, pteridine reductase, pteridine reductase 1, pteridine reductase I, PTR1, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide phosphate), Tb-PR, TbPTR1, tcptr1
ECTree
1.5.1.33 pteridine reductaseAdvanced search results
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results (KM Value
KM Value on EC 1.5.1.33 - pteridine reductase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.0347
7,8-dihydrobiopterin
recombinant wild-type enzyme, pH 6.0, 25°C
0.0951
7,8-dihydroneopterin
recombinant wild-type enzyme, pH 6.0, 25°C
0.0713
7,8-dihydromonapterin
recombinant wild-type enzyme, pH 6.0, 25°C
0.1694
7,8-dihydromonapterin
recombinant mutant R24A, pH 6.0, 25°C
0.2127
7,8-dihydromonapterin
recombinant mutant Y163F, pH 6.0, 25°C
0.3332
7,8-dihydromonapterin
recombinant mutant Y161F/Y163F, pH 6.0, 25°C
0.505
7,8-dihydromonapterin
recombinant mutant Y161A, pH 6.0, 25°C
0.0122
biopterin
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NADPH, with folate as cosubstrate, recombinant enzyme, pH 6.0
0.00935
NADPH
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with dihydrobiopterin as cosubstrate, recombinant enzyme, pH 4.7
0.012
NADPH
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with dihydrofolate as cosubstrate, recombinant enzyme, pH 6.0
0.0123
NADPH
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with biopterin as cosubstrate, recombinant enzyme, pH 4.7
0.0142
NADPH
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with dihydrofolate as cosubstrate, recombinant enzyme, pH 6.0
0.0145
NADPH
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with dihydrobiopterin as cosubstrate, recombinant enzyme, pH 4.7
0.0166
quinonoid 6,7-dimethyl-7,8-dihydropterin
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in 50 mM HEPES buffer, pH 7.4, at 25°C
0.021
quinonoid 6,7-dimethyl-7,8-dihydropterin
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in 50 mM HEPES buffer, pH 7.4, at 25°C
0.0036
quinonoid dihydrobiopterin
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in 50 mM HEPES buffer, pH 7.4, at 25°C
additional information
additional information
steady-state kinetic analysis
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additional information
additional information
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kinetics, thermal shift assay
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additional information
additional information
kinetics by non-tight binding Michaelis-Menten model
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