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gene dhfr-ts
UniProt
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SwissProt
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Uniprot
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overview
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brenda
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UniProt
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trimethoprim-susceptible strain PC 174 and trimethoprim-resistant strain PC 178
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UniProt
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var. durans
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Uniprot
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Halalkalibacterium halodurans
Halalkalibacterium halodurans C-125
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SwissProt
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i.e. Helicoverpa virescens, tobacco budworm
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human virus produced in cultured lymphoma derived B-cells
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R-plasmid encoded, trimethoprim-resistant
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UniProt
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UniProt
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bifunctional dihydrofolate reductase-thymidylate synthase, cf. EC 2.1.1.45
UniProt
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UniProt
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UniProt
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UniProt
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Uniprot
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2 forms, not genetically determined isozymes
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UniProt
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bifunctional dihydrofolate reductase-thymidylate synthase, cf. EC 2.1.1.45
UniProt
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bifunctional dihydrofolate reductase-thymidylate synthase, cf. EC 2.1.1.45
UniProt
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bifunctional dihydrofolate reductase/thymidylate synthase
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UniProt
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UniProt
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trimethoprim-resistant enzyme
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UniProt
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methicillin-sensitive and -resistant strains
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Tequatrovirus T4
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SwissProt
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UniProt
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UniProt
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overview
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brenda
sequence lacks a crucial, conserved 13 amino acid loop
UniProt
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brenda
bifunctional dihydrofolate reductase-thymidylate synthase 1, cf. EC 2.1.1.45
UniProt
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bifunctional dihydrofolate reductase-thymidylate synthase 2, cf. EC 2.1.1.45
UniProt
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brenda
2 forms
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calf
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overview
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brenda
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UniProt
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chinese hamster, methotrexate-sensitive and methotrexate-resistant cells
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2 forms: I, II
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baby hamster kidney cells
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wild type and methotrexate-resistant
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bifunctional enzyme: dihydrofolate reductase-thymidylate synthase EC 2.1.1.45
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bifunctional enzyme: pteridine reductase-dihydrofolate reductase
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three different forms I, IIa and IIb
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UniProt
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chain A
UniProt
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Uniprot
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wild carrot, enzyme complex with dihydrofolate reductase activity, thymidylate synthase activity and three other polypeptides of unknown function
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expression in Chinese hamster ovary cells
Uniprot
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UniProt
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2 forms termed mutant type and wild-type enzyme in a single organism
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amethopterin-resistant strain
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overview
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brenda
var. durans
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392207, 392210, 392212, 392213, 392214, 392217, 392218, 392220, 392222, 392226, 392228, 392241, 392277 -
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Uniprot
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Uniprot
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Uniprot
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Uniprot
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Uniprot
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Uniprot
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Uniprot
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Uniprot
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Uniprot
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UniProt
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Uniprot
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Uniprot
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Uniprot
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amethopterin-resistant
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isoenzymes type I and type II, resistant to trimethoprim
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isozyme type II, R-plasmid encoded
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brenda
isozyme type II, R-plasmid encoded isoform R67
UniProt
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methotrexate-resistant mutant
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plasmid-encoded isoform R67
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plasmid-encoded isoform R67
UniProt
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plasmid-encoded R67 isoform
UniProt
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seleno- and telluromethionine-containing enzyme
Uniprot
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strains: MB3746, MB 3747 of K12
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trimethoprim-resistant strain
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various strains
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brenda
wild-type and mutants
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brenda
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Uniprot
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overview
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brenda
Halalkalibacterium halodurans
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Halalkalibacterium halodurans
expression in Escherichia coli
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AB986558
GenBank
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AB986558
GenBank
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SwissProt
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SwissProt
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extremely halophilic archaebacterium
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isozyme hDHFR-1 from gene hdrA and isozyme hDHFR-2 from gene hdrB
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UniProt
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UniProt
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UniProt
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UniProt
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UniProt
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UniProt
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UniProt
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UniProt
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UniProt
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UniProt
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c.86 + 60_78 insertion/deletion polymorphism is associated with serum and red blood cell folate concentrations in women
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cancer patients with and without thrombosis
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children with acute lymphoblastic leukemia
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brenda
cultured mammalian cells, overview
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brenda
methotrexate-resistant WIL-2 lymphoblastoid cells
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methotrexate-sensitive cell line HeLa BU-25, methotrexate-insensitive cell line VA2-B
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mothers of a spina bifida affected child, spina biWda patients, and controls
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patients with osteosarcoma
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Uniprot
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amethopterin-resistant
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antifolate-resistant strain
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brenda
isozymes I and II
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methotrexate-resistant
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brenda
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brenda
bifunctional dihydrofolate reductase-thymidylate synthase, cf. EC 2.1.1.45
UniProt
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bifunctional enzyme dihydrofolate reductase-thymidylate synthase
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methotrexate-resistant strain with altered enzyme
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methotrexate resistant bifunctional enzyme: thymidylate synthase-dihydrofolate reductase
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brenda
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brenda
cultured mammalian cells, overview
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brenda
isoform DFRa
UniProt
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isoform DfrB
UniProt
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brenda
sp. nov.
Uniprot
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UniProt
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UniProt
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UniProt
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altered enzyme encoded by amplified genes in cultured fibroblasts
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L1210 lymphoma cells
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L1210 lymphoma cells, amethopterin-resistant
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brenda
multiple forms
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overview
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brenda
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SwissProt
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Uniprot
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Uniprot
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Uniprot
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Pigeon
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brenda
Pigeon
overview
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brenda
bifunctional enzyme: dihydrofolate reductase-thymidylate synthase EC 2.1.1.45
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brenda
pyrimethamine-sensitive and pyrimethamine-resistant strain
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brenda
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brenda
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Uniprot
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Uniprot
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bifunctional thymidylate synthase-dihydrofolate reductase
Uniprot
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isolated from infected Kenyan adults
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isolated from Sudanese patients treated with sulphadoxine/pyrimethamine or sulphadoxine/pyrimethamine plus chloroquine
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isolates from Car Nicobar Island, India
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isolates from Cote d'Ivoire
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isolates from Malawi
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isolates from Mozambique
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isolates from southern Mozambique
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several Ser108 mutants
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brenda
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Uniprot
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fragment; bifunctional dihydrofolate reductase-thymidylate synthase
UniProt
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isolates from Sri Lanka
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brenda
polymorphisms in Indian field isolates
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brenda
wild-type and mutant enzymes recombinant from Escherichia coli
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brenda
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Uniprot
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Uniprot
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human-derived
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rat-derived
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brenda
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UniProt
brenda
recombinant human-derived and rat-derived enzyme
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brenda
protozoa
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brenda
protozoa
overview
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brenda
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brenda
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Uniprot
brenda
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Uniprot
brenda
carcinoma Walker 256
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brenda
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brenda
phage type 179, R-plasmid enzyme, isozyme type III
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brenda
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UniProt
brenda
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SwissProt
brenda
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brenda
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UniProt
brenda
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brenda
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UniProt
brenda
methicillin-sensitive and -resistant strains
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brenda
trimethoprim-resistant enzyme
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brenda
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Uniprot
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methicillin-sensitive and -resistant strains
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brenda
methotrexate-resistant form
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brenda
wild-type and mutant forms
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brenda
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brenda
overview
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brenda
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brenda
green algae, thymidylate synthase and dihydrofolate reductase cannot be dissociated from each other
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brenda
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brenda
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SwissProt
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thermophilic bacterium
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UniProt
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brenda
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UniProt
brenda
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brenda
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UniProt
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bifunctional dihydrofolate reductase-thymidylate synthase
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brenda
bifuntional enzyme with dihydrofolate reductase and thymidylate synthase activity
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brenda
trimethoprim-resistant strain
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brenda
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brenda
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UniProt
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UniProt
brenda
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UniProt
brenda
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SwissProt
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brenda