1.5.1.20: methylenetetrahydrofolate reductase [NAD(P)H]

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For detailed information about methylenetetrahydrofolate reductase [NAD(P)H], go to the full flat file.

Reaction

Synonyms

10-methylenetetrahydrofolate reductase, 5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methylenetetrahydrofolate:NADP+ oxidoreductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, 5-methyltetrahydrofolate:NAD oxidoreductase, 5-methyltetrahydrofolate:NAD+ oxidoreductase, 5-methyltetrahydrofolate:NADP+ oxidoreductase, AtMTHFR-1, EC 1.1.1.171, EC 1.1.1.68, EC 1.1.99.15, EC 1.7.99.5, HsMTHFR, MET13, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase (NADPH), methylenetetrahydrofolic acid reductase, MetVF-type methylenetetrahydrofolate reductase, More, MTHFR, MTHFR2, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase, NADH:CH2-H4folate oxidoreductase, NapAB, reductase, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate), reductase, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide), respiratory nitrate reductase, type II-MTHFR

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]

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Results	in table
9	Activating Compound
46906	AA Sequence
26	Application
2	CAS Registry Number
19	Cloned(Commentary)
150	Cofactor
9	Crystallization (Commentary)
177	Disease/ Diagnostics
18	General Information
8	General Stability
9	IC50 Value
68	Inhibitors
4	kcat/KM [mM/s]
14	Ki Value [mM]
70	KM Value [mM]
13	Localization
12	Metals/Ions
31	Molecular Weight [Da]
50	Natural Substrates/ Products (Substrates)
291	Organism
2	Oxidation Stability
6	Pathway
37	PDB ID
16	pH Optimum
4	pH Range
1	pH Stability
4	Posttranslational Modification
175	Protein Variants
26	Purification (Commentary)
9	Reaction
3	Reaction Type
261	Reference
1	Renatured (Commentary)
125	Source Tissue
33	Specific Activity [micromol/min/mg]
6	Storage Stability
280	Substrates and Products (Substrate)
30	Subunits
407	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
1	Temperature Range [°C]
9	Temperature Stability [°C]
25	Turnover Number [1/s]

pH Range

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pH Range on EC 1.5.1.20 - methylenetetrahydrofolate reductase [NAD(P)H]

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5 - 9

Clostridium ljungdahlii

A0A162J7F3

2% activity remain at pH 5.0, and 6% activity at pH 9.0

764937

5.8 - 8.6

Sus scrofa

-

about 60% of activity maximum at pH 5.8, about 50% of activity maximum at pH 8.6, menadione reductase activity

392149

6 - 8

Rattus norvegicus

-

pH 6: about 70% of activity maximum, pH 8: about 35% of activity maximum with 5-methyl-5,6,7,8-tetrahydropteroylmonoglutamate, about 65% of activity maximum with 5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate

437717

6.2 - 7.3

Sus scrofa

-

half-maximal activity at pH 6.2 and pH 7.3, methylenetetrahydrofolate reductase reaction

392149