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1.5.1.20: methylenetetrahydrofolate reductase [NAD(P)H]

This is an abbreviated version!
For detailed information about methylenetetrahydrofolate reductase [NAD(P)H], go to the full flat file.

Word Map on EC 1.5.1.20

Reaction

5-methyltetrahydrofolate
+
NAD(P)+
=
5,10-methylenetetrahydrofolate
+
NAD(P)H
+
H+

Synonyms

10-methylenetetrahydrofolate reductase, 5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methylenetetrahydrofolate:NADP+ oxidoreductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, 5-methyltetrahydrofolate:NAD oxidoreductase, 5-methyltetrahydrofolate:NAD+ oxidoreductase, 5-methyltetrahydrofolate:NADP+ oxidoreductase, AtMTHFR-1, EC 1.1.1.171, EC 1.1.1.68, EC 1.1.99.15, EC 1.7.99.5, HsMTHFR, MET13, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase (NADPH), methylenetetrahydrofolic acid reductase, MetVF-type methylenetetrahydrofolate reductase, More, MTHFR, MTHFR2, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase, NADH:CH2-H4folate oxidoreductase, NapAB, reductase, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate), reductase, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide), respiratory nitrate reductase, type II-MTHFR

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]

General Stability

General Stability on EC 1.5.1.20 - methylenetetrahydrofolate reductase [NAD(P)H]

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
0.005 mM FAD stabilizes enzyme during purification procedure
-
extremely sensitive to proteolysis
FAD stabilizes
-
folate and FAD stabilize the polymorphic mutant enzyme
-
methyltetrahydrofolate and S-adenosylmethionine protects enzyme from the loss of FAD after dilution