1.5.1.15: methylenetetrahydrofolate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about methylenetetrahydrofolate dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

5,10-CH2-THF dehydrogenase, 5,10-methylenetetrahydrofolate reductase, bifunctional N5,N10-methylene-H4F dehydrogenase/N5,N10-methenyltetrahydrofolate cyclohydrolase, FolD, methenyltetrahydrofolate cyclohydrolase, methylenetetrahydrofolate dehydrogenase (NAD+-dependent), methylenetetrahydrofolate dehydrogenase-cyclohydrolase, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase, methylenetetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, methylenetetrahydrofolate reductase, methyleneTHF dehydrogenase, Mg2+-/phosphate-dependent dehydrogenase, Mg2+/NAD-dependent methylenetetrahydrofolate dehydrogenase, More, MSMEG_6596, MSMEG_6649, MTD, MTHFD2, MTHFD2L, MTHFR, MTHFR1, MTHFR2, NAD+-dependent methylene-H4F dehydrogenase, NAD-dependent dehydrogenase-cyclohydrolase, NADH-oxidizing methylenetetrahydrofolate reductase, NMDMC

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.15 methylenetetrahydrofolate dehydrogenase (NAD+)

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Results	in table
9	Activating Compound
43	AA Sequence
6	Application
1	CAS Registry Number
21	Cloned(Commentary)
49	Cofactor
3	Crystallization (Commentary)
20595	Disease/ Diagnostics
1	Expression
10	General Information
1	General Stability
7	Inhibitors
13	kcat/KM [mM/s]
7	Ki Value [mM]
63	KM Value [mM]
59	Localization
21	Metals/Ions
28	Molecular Weight [Da]
149	Natural Substrates/ Products (Substrates)
100	Organism
1	Oxidation Stability
3	Pathway
23	PDB ID
4	pH Optimum
1	pH Range
1	pH Stability
24	Protein Variants
23	Purification (Commentary)
2	Reaction
3	Reaction Type
86	Reference
79	Source Tissue
101	Specific Activity [micromol/min/mg]
3	Storage Stability
183	Substrates and Products (Substrate)
28	Subunits
59	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Stability [°C]
21	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.5.1.15 - methylenetetrahydrofolate dehydrogenase (NAD+)

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

(2S)-2-[[4-[(6aR)-3-amino-1,9-dioxo-5,6,6a,7-tetrahydro-4H-imidazo[1,5-f]pteridin-8-yl]benzoyl]amino]pentanedioic acid

Homo sapiens

P13995

i.e. LY345899

756337

5,10-methylenetetrahydrofolate

Escherichia coli

-

substrate inhibition of wild-type enzyme and mutant Q183E, no inhibition of mutant Q183A

760434

EDTA

Mus musculus

-

NAD+ dependent enzyme from Ehrlich ascites tumor cells

392075

menadione

Escherichia coli

-

substrate inhibition of wild-type enzyme and mutant Q183A, no inhibition of mutant Q183E

760434

NADH

Escherichia coli

-

substrate inhibition

760434

S-adenosyl-L-methionine

Mus musculus

Q9WU20

allosteric inhibitor, enzyme contains a binding site at the C-terminus

654447

Zn2+

Acetobacterium woodii

-

-

392076