1.4.99.B3: L-amino acid dehydrogenase (cytochrome b)
This is an abbreviated version!
For detailed information about L-amino acid dehydrogenase (cytochrome b), go to the full flat file.
Word Map on EC 1.4.99.B3
Reaction
Synonyms
L-amino acid deaminase, LAAD
ECTree
1.4.99.B3 L-amino acid dehydrogenase (cytochrome b)Advanced search results
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results (Substrates Products
Substrates Products on EC 1.4.99.B3 - L-amino acid dehydrogenase (cytochrome b)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-arginine + H2O + 2 cytochrome b
2-oxo-5-guanidinopentanoic acid + NH3 + 2 reduced cytochrome b
-
-
68% of the activity with L-phenylalanine
-
?
L-Dopa + H2O + 2 cytochrome b
3-(3,4-dihydroxyphenyl)-pyruvate + NH3 + 2 reduced cytochrome b
-
56.7% of the activitywith L-phenylalanine
-
?
L-histidine + H2O + 2 cytochrome b
2-oxo-4-imidazolepropionic acid + NH3 + 2 reduced cytochrome b
-
-
174% of the activity with L-phenylalanine
-
?
L-isoleucine + H2O + 2 cytochrome b
3-methyl-2-oxo-pentanoate + NH3 + 2 reduced cytochrome b
L-methionine + H2O + 2 cytochrome b
4-methylsulfanyl-2-oxobutanoate + NH3 + 2 reduced cytochrome b
L-norleucine + H2O + 2 cytochrome b
2-oxohexanoate + NH3 + 2 reduced cytochrome b
-
-
82% of the activity with L-phenylalanine
-
?
L-ornithine + H2O + 2 cytochrome b
2-oxo-5-aminopentanoate + NH3 + 2 reduced cytochrome b
-
-
73% of the activity with L-phenylalanine
-
?
L-phenylalanine + H2O + 2 cytochrome b
phenylpyruvate + NH3 + 2 reduced cytochrome b
-
-
-
?
L-phenylalanine + H2O + 2 cytochrome c
phenylpyruvate + NH3 + 2 reduced cytochrome c
-
-
acceptor horse cytochrome c
-
?
L-phenylalanine + H2O + 2,6-dichlorophenolindophenol
phenylpyruvate + NH3 + reduced 2,6-dichlorophenolindophenol
-
membrane-free enzyme can be assayed using 2,6-dichlorophenolindophenol as acceptor
-
?
L-phenylalanine + H2O + dichlorophenolindophenol
phenylpyruvate + NH3 + reduced dichlorophenolindophenol
-
-
-
-
?
L-phenylalanine ethyl ester + H2O + 2 cytochrome b
phenylpyruvate ethyl ester + NH3 + 2 reduced cytochrome b
-
33% of the activitywith L-phenylalanine
-
?
L-tryptophan + H2O + 2 cytochrome b
3-(1H-indol-3-yl)-2-oxopropanoic acid + NH3 + 2 reduced cytochrome b
L-cysteine + H2O + 2 cytochrome b
2-oxo-3-thiopropanoate + NH3 + 2 reduced cytochrome b
-
43% of the activitywith L-phenylalanine
-
?
L-cysteine + H2O + 2 cytochrome b
2-oxo-3-thiopropanoate + NH3 + 2 reduced cytochrome b
-
71.5% of the activiy with L-phenylalanine
-
?
L-cysteine + H2O + 2 cytochrome b
2-oxo-3-thiopropanoate + NH3 + 2 reduced cytochrome b
Proteus myxofaciens 4482
-
71.5% of the activiy with L-phenylalanine
-
?
L-isoleucine + H2O + 2 cytochrome b
3-methyl-2-oxo-pentanoate + NH3 + 2 reduced cytochrome b
-
27.8% of the activiy with L-phenylalanine
-
?
L-isoleucine + H2O + 2 cytochrome b
3-methyl-2-oxo-pentanoate + NH3 + 2 reduced cytochrome b
-
43% of the activitywith L-phenylalanine
-
?
L-isoleucine + H2O + 2 cytochrome b
3-methyl-2-oxo-pentanoate + NH3 + 2 reduced cytochrome b
Proteus myxofaciens 4482
-
27.8% of the activiy with L-phenylalanine
-
?
L-leucine + H2O + 2 cytochrome b
2-oxo-4-methylpentanoate + NH3 + 2 reduced cytochrome b
-
-
69% of the activity with L-phenylalanine
-
?
L-leucine + H2O + 2 cytochrome b
2-oxo-4-methylpentanoate + NH3 + 2 reduced cytochrome b
-
111% of the activiy with L-phenylalanine
-
?
L-leucine + H2O + 2 cytochrome b
2-oxo-4-methylpentanoate + NH3 + 2 reduced cytochrome b
-
99.2% of the activitywith L-phenylalanine
-
?
L-leucine + H2O + 2 cytochrome b
2-oxo-4-methylpentanoate + NH3 + 2 reduced cytochrome b
Proteus myxofaciens 4482
-
111% of the activiy with L-phenylalanine
-
?
L-methionine + H2O + 2 cytochrome b
4-methylsulfanyl-2-oxobutanoate + NH3 + 2 reduced cytochrome b
-
-
74% of the activity with L-phenylalanine
-
?
L-methionine + H2O + 2 cytochrome b
4-methylsulfanyl-2-oxobutanoate + NH3 + 2 reduced cytochrome b
-
102% of the activiy with L-phenylalanine
-
?
L-methionine + H2O + 2 cytochrome b
4-methylsulfanyl-2-oxobutanoate + NH3 + 2 reduced cytochrome b
-
86% of the activitywith L-phenylalanine
-
?
L-methionine + H2O + 2 cytochrome b
4-methylsulfanyl-2-oxobutanoate + NH3 + 2 reduced cytochrome b
Proteus myxofaciens 4482
-
102% of the activiy with L-phenylalanine
-
?
L-tryptophan + H2O + 2 cytochrome b
3-(1H-indol-3-yl)-2-oxopropanoic acid + NH3 + 2 reduced cytochrome b
-
60.5% of the activitywith L-phenylalanine
-
?
L-tryptophan + H2O + 2 cytochrome b
3-(1H-indol-3-yl)-2-oxopropanoic acid + NH3 + 2 reduced cytochrome b
-
90.6% of the activiy with L-phenylalanine
-
?
L-tyrosine + H2O + 2 cytochrome b
4-hydroxyphenylpyruvate + NH3 + 2 reduced cytochrome b
-
13.7% of the activitywith L-phenylalanine
-
?
L-tyrosine + H2O + 2 cytochrome b
4-hydroxyphenylpyruvate + NH3 + 2 reduced cytochrome b
-
38.5% of the activiy with L-phenylalanine
-
?
additional information
?
-
-
one mol of phenylpyruvate is produced per half mol O2 used in the reaction. The process is carried on by amino acid specific flavoproteins and cytochromes b1, a1 and a2 of the respiratory chain
-
-
?
additional information
?
-
aliphatic, aromatic or sulfur-containing amino acids are preferred. The reaction has an absolute requirement for O2, releases NH3 and does not produce H2O2
-
-
?
additional information
?
-
the enzyme does not use dioxygen to reoxidize reduced FADH2 and does not produce hydrogen peroxide, instead, it uses a cytochrome b-like protein as an electron acceptor. No substrates: D-amino acids
-
-
?
additional information
?
-
-
the enzyme does not use dioxygen to reoxidize reduced FADH2 and does not produce hydrogen peroxide, instead, it uses a cytochrome b-like protein as an electron acceptor. No substrates: D-amino acids
-
-
?
additional information
?
-
Proteus myxofaciens 4482
aliphatic, aromatic or sulfur-containing amino acids are preferred. The reaction has an absolute requirement for O2, releases NH3 and does not produce H2O2
-
-
?
