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1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
-
?
1,4-diamino-2-butyne + H2O + O2
?
1,4-diamino-2-chloro-2-butene + H2O + O2
?
1,4-diaminobutane + H2O + O2
?
-
enzyme II shows 23% activity and enzyme III 12% activity compared to 4-aminobutanamide
-
-
?
1,5-diamino-2-pentyne + H2O + O2
?
1,5-diaminopentane + H2O + O2
?
-
enzyme II shows 5% activity and enzyme III 31% activity compared to 4-aminobutanamide
-
-
?
1,6-diamino-2,4-hexadiyne + H2O + O2
?
1,8-diaminooctane + H2O + O2
?
-
-
-
-
?
1-(3-fluoro-4-methylphenyl)methanamine + H2O + O2
? + NH3 + H2O2
1-(4-fluorophenyl)methanamine + H2O + O2
? + NH3 + H2O2
1-aminobutane + H2O + O2
butanal + NH3 + H2O2
-
-
-
-
?
1-aminoheptane + H2O + O2
heptanal + NH3 + H2O2
-
-
-
-
?
1-aminohexane + H2O + O2
hexanal + NH3 + H2O2
-
-
-
-
?
1-aminononane + H2O + O2
nonanal + NH3 + H2O2
-
the aliphatic chain of 1-aminononane induces a shift in the pKa-value of the product Schiff base, the hydrolysis of which appears to be a rate-determining step of the reaction
-
-
?
1-aminooctane + H2O + O2
octanal + NH3 + H2O2
-
-
-
-
?
1-aminopentane + H2O + O2
pentanal + NH3 + H2O2
-
-
-
-
?
1-methyl-3-phenylpropylamine + H2O + O2
4-phenylbutan-2-one + NH3 + H2O2
-
-
-
-
?
1-methylhistamine + O2 + H2O
?
-
-
-
?
2-aminoethylpyridine + H2O + O2
pyridine-2-carbaldehyde + NH3 + H2O2
-
-
-
?
2-bromoethylamine + H2O + O2
bromoacetaldehyde + NH3 + H2O2
2-phenylethanamine + H2O + O2
? + NH3 + H2O2
2-phenylethylamine + H2O + O2
2-phenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
2-phenylethylamine + H2O + O2
?
-
-
-
?
2-phenylethylamine + H2O + O2
beta-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2
?
3-aminomethylpyridine + H2O + O2
pyridine-3-carbaldehyde + NH3 + H2O2
-
-
-
?
3-aminopentanamide + H2O + O2
3-oxopentanamide + NH3 + H2O2
-
enzyme II shows 214% activity and enzyme III 11% activity compared to 4-aminobutanamide
-
-
?
3-phenylpropan-1-amine + H2O + O2
? + NH3 + H2O2
4-(aminomethyl)-N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
? + NH3 + H2O2
4-amino-1-butanol + H2O + O2
4-hydroxybutanal + NH3 + H2O2
-
enzyme II shows 525% activity and enzyme III 267% activity compared to 4-aminobutanamide
-
-
?
4-aminobutanamide + H2O + O2
4-oxobutanamide + NH3 + H2O2
-
100% activity
-
-
?
4-aminobutyric acid + H2O + O2
4-oxobutanoate + NH3 + H2O2
-
enzyme II shows no activity and enzyme III 10% activity compared to 4-aminobutanamide
-
-
?
4-aminomethylpyridine + H2O + O2
pyridine-4-carbaldehyde + NH3 + H2O2
-
-
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2
?
4-fluorobenzylamine + H2O + O2
4-fluorobenzaldehyde + NH3 + H2O2
-
-
-
-
?
4-N,N-dimethylaminomethyl benzylamine + H2O + O2
?
-
-
-
-
?
4-phenylbutan-1-amine + H2O + O2
? + NH3 + H2O2
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
5-amino-1-pentanol + H2O + O2
5-hydroxypentanal + NH3 + H2O2
-
enzyme II shows 86% activity and enzyme III 388% activity compared to 4-aminobutanamide
-
-
?
5-aminopentanoic acid + H2O + O2
5-oxopentanoate + NH3 + H2O2
-
enzyme II shows 3% activity and enzyme III 7% activity compared to 4-aminobutanamide
-
-
?
5-hydroxytryptamine + H2O + O2
?
agmatine + H2O + O2
?
-
-
-
?
allyl [3-(aminomethyl)benzyl]carbamate + H2O + O2
? + NH3 + H2O2
alpha-casein + H2O + O2
?
-
the enzyme oxidizes the lysine residues in alpha-casein protein
-
-
?
aminoacetone + H2O + O2
methylglyoxal + NH3 + H2O2
amphetamine + H2O + O2
1-phenylpropan-2-one + NH3 + H2O2
-
-
-
-
?
amylamine + H2O + O2
pentanal + NH3 + H2O2
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
benzylamine + O2 + H2O
benzaldehyde + NH3 + H2O2
-
-
-
?
beta-phenylethylamine + H2O + O2
beta-phenylethanal + NH3 + H2O2
-
-
-
?
beta-phenylethylamine + O2 + H2O
beta-phenylethanal + NH3 + H2O2
-
-
-
?
butylamine + H2O + O2
butanal + NH3 + H2O2
cadaverine + H2O + O2
DELTA1-piperideine + NH3 + H2O2
best substrate
-
-
?
cyclohexanemethylamine + H2O + O2
cyclohexanecarbaldehyde + NH3 + H2O2
-
-
-
?
cysteamine + H2O + O2
sulfanylacetaldehyde + NH3 + H2O2
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
dopamine + H2O + O2
?
-
-
-
?
ethanolamine + H2O + O2
glycolaldehyde + NH3 + H2O2
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
ethylamine + H2O + O2
ethanal + NH3 + H2O2
-
-
-
-
?
hexakis(benzylammonium) decavanadate (V) dihydrate + H2O + O2
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
isoamylamine + H2O + O2
isoamylaldehyde + NH3 + H2O2
isobutylamine + H2O + O2
isobutyraldehyde + NH3 + H2O2
-
-
-
?
isopentylamine + H2O + O2
isopentylaldehyde + NH3 + H2O2
-
-
-
-
?
methyl 1-(2-methoxyethyl)-3-(trifluoroacetyl)-1H-indole-4-carboxylate + H2O + O2
?
-
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
methylamine + H2O + O2
methanal + NH3 + H2O2
methylbenzylamine + H2O + O2
methylbenzaldehyde + NH3 + H2O2
-
-
-
-
?
n-butylamine + H2O + O2
butanal + NH3 + H2O2
-
enzyme II shows 368% activity and enzyme III 454% activity compared to 4-aminobutanamide
-
-
?
n-hexylamine + H2O + O2
hexanal + NH3 + H2O2
-
enzyme II shows 244% activity and enzyme III 589% activity compared to 4-aminobutanamide
-
-
?
n-pentylamine + H2O + O2
pentanal + NH3 + H2O2
-
enzyme II shows 314% activity and enzyme III 596% activity compared to 4-aminobutanamide
-
-
?
n-propylamine + H2O + O2
propanal + NH3 + H2O2
-
enzyme II shows 515% activity and enzyme III 201% activity compared to 4-aminobutanamide
-
-
?
N-[3-(aminomethyl)benzyl]-4-bromobenzamide + H2O + O2
? + NH3 + H2O2
N-[3-(aminomethyl)benzyl]acetamide + H2O + O2
? + NH3 + H2O2
N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
? + NH3 + H2O2
N-[3-(aminomethyl)benzyl]propanamide + H2O + O2
? + NH3 + H2O2
N6-(4-aminobut-2-ynyl)adenine + H2O + O2
?
Nalpha-benzyloxycarbony-L-lysine + H2O + O2
?
-
enzyme II shows 3% activity and enzyme III 12% activity compared to 4-aminobutanamide
-
-
?
Nalpha-Z-D-lysine + H2O + O2
?
-
enzyme II shows no activity and enzyme III 10% activity compared to 4-aminobutanamide
-
-
?
octopamine + H2O + O2
hydroxy(hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
ornithine + H2O + O2
?
ornithine can be transformed in glutamate-5-semialdehyde spontaneously cyclizes yielding DELTA1-pyrroline-5-carboxylic acid
-
-
?
phenethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
-
-
?
phenylethyl amine + H2O + O2
phenylethanal + NH3 + H2O2
-
-
-
-
?
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
propylamine + H2O + O2
propanal + NH3 + H2O2
putrescine + H2O + O2
4-aminobutanal + NH3 + H2O2
putrescine + H2O + O2
4-aminobutyraldehyde + NH3 + H2O2
-
-
-
-
?
pyrrolidine + 2,4,5-trihydroxyphenylalanine quinone + H2O + O2
? + H2O2 + NH3
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
sec-butylamine + H2O + O2
butan-2-one + NH3 + H2O2
-
-
-
-
?
serotonin + O2 + H2O
(5-hydroxy-1H-indol-3yl)acetaldehyde + NH3 + H2O2
-
-
-
?
spermidine + H2O + O2
? + NH3 + H2O2
good substrate. The oxidation of spermidine yields to the liberation of ammonia, hydrogen peroxide and the corresponding aldehyde that spontaneously cyclizes yielding first 1-(3-aminopropyl)pyrroliniun and, thereafter, 1,5-diazobicyclononane
-
-
?
spermine + H2O + O2
? + NH3 + H2O2
good substrate
-
-
?
tropoelastin + H2O + O2
?
-
the enzyme oxidizes the lysine residues in tropoelastin protein
-
-
?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
tyramine + H2O + O2
4-hydroxyphenylacetaldehyde + NH3 + H2O2
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
tyramine + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
tyramine + O2 + H2O
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
vanillylamine + H2O + O2
vanillic aldehyde + NH3 + H2O2
-
-
-
-
?
additional information
?
-
1,4-diamino-2-butyne + H2O + O2
?
-
-
-
?
1,4-diamino-2-butyne + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
1,4-diamino-2-butyne + H2O + O2
?
-
-
-
-
?
1,4-diamino-2-butyne + H2O + O2
?
-
-
-
?
1,4-diamino-2-chloro-2-butene + H2O + O2
?
-
-
-
?
1,4-diamino-2-chloro-2-butene + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
1,4-diamino-2-chloro-2-butene + H2O + O2
?
-
-
-
-
?
1,4-diamino-2-chloro-2-butene + H2O + O2
?
-
-
-
?
1,5-diamino-2-pentyne + H2O + O2
?
-
-
-
?
1,5-diamino-2-pentyne + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
1,5-diamino-2-pentyne + H2O + O2
?
-
-
-
-
?
1,5-diamino-2-pentyne + H2O + O2
?
-
-
-
?
1,6-diamino-2,4-hexadiyne + H2O + O2
?
-
-
-
?
1,6-diamino-2,4-hexadiyne + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
1,6-diamino-2,4-hexadiyne + H2O + O2
?
-
-
-
-
?
1,6-diamino-2,4-hexadiyne + H2O + O2
?
-
-
-
?
1-(3-fluoro-4-methylphenyl)methanamine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
1-(3-fluoro-4-methylphenyl)methanamine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
1-(4-fluorophenyl)methanamine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
1-(4-fluorophenyl)methanamine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
2-bromoethylamine + H2O + O2
bromoacetaldehyde + NH3 + H2O2
-
-
-
?
2-bromoethylamine + H2O + O2
bromoacetaldehyde + NH3 + H2O2
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
2-bromoethylamine + H2O + O2
bromoacetaldehyde + NH3 + H2O2
-
-
-
-
?
2-bromoethylamine + H2O + O2
bromoacetaldehyde + NH3 + H2O2
-
-
-
?
2-phenylethanamine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
2-phenylethanamine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
preferred substrate
-
-
?
2-phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
enzyme II shows 134% activity and enzyme III 591% activity compared to 4-aminobutanamide
-
-
?
2-phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
best substrate
-
-
?
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2
?
-
-
-
?
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2
?
-
-
-
-
?
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2
?
-
-
-
?
3-phenylpropan-1-amine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
3-phenylpropan-1-amine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
4-(aminomethyl)-N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
4-(aminomethyl)-N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2
?
45% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (beta-phenylethylamine, 1 mM) for various amine oxidases
-
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2
?
less than 0.1% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (putrescine, 1 mM) for various amine oxidases
-
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2
?
-
87% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (benzylamine, 1 mM) for various amine oxidases
-
-
?
4-phenylbutan-1-amine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
4-phenylbutan-1-amine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
-
enzyme II shows 122% activity and enzyme III 493% activity compared to 4-aminobutanamide
-
-
?
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
-
enzyme II shows 122% activity and enzyme III 493% activity compared to 4-aminobutanamide
-
-
?
5-hydroxytryptamine + H2O + O2
?
-
enzyme II shows no activity and enzyme III 6% activity compared to 4-aminobutanamide
-
-
?
5-hydroxytryptamine + H2O + O2
?
-
enzyme II shows no activity and enzyme III 6% activity compared to 4-aminobutanamide
-
-
?
allyl [3-(aminomethyl)benzyl]carbamate + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
allyl [3-(aminomethyl)benzyl]carbamate + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
aminoacetone + H2O + O2
methylglyoxal + NH3 + H2O2
-
-
-
-
?
aminoacetone + H2O + O2
methylglyoxal + NH3 + H2O2
-
-
-
?
amylamine + H2O + O2
pentanal + NH3 + H2O2
-
-
-
?
amylamine + H2O + O2
pentanal + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
very poor substrate
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
enzyme II shows 4% activity and enzyme III 157% activity compared to 4-aminobutanamide
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
enzyme II shows 4% activity and enzyme III 157% activity compared to 4-aminobutanamide
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
best substrate
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
low activity
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
best oxidized substrate
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
best oxidized substrate
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
686052, 686264, 687077, 688484, 688489, 688553, 688603, 689375, 689376, 705350, 712188 -
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
main substrate for isoform AO1
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
main substrate for isoform AO1
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
butylamine + H2O + O2
butanal + NH3 + H2O2
-
-
-
?
butylamine + H2O + O2
butanal + NH3 + H2O2
-
-
-
-
?
cadaverine + H2O + O2
?
-
-
-
?
cadaverine + H2O + O2
?
-
-
-
?
cadaverine + H2O + O2
?
-
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
ethanolamine + H2O + O2
glycolaldehyde + NH3 + H2O2
-
-
-
-
?
ethanolamine + H2O + O2
glycolaldehyde + NH3 + H2O2
-
-
-
-
?
ethanolamine + H2O + O2
glycolaldehyde + NH3 + H2O2
-
-
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
enzyme II shows 1124% activity and enzyme III 119% activity compared to 4-aminobutanamide
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
-
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
isoforms AO1 and AO2 show 100% activity with ethylamine
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
-
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
-
-
-
?
hexakis(benzylammonium) decavanadate (V) dihydrate + H2O + O2
?
-
-
-
-
?
hexakis(benzylammonium) decavanadate (V) dihydrate + H2O + O2
?
-
-
-
-
?
hexakis(benzylammonium) decavanadate (V) dihydrate + H2O + O2
?
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
enzyme II shows 6% activity and enzyme III 322% activity compared to 4-aminobutanamide
-
-
?
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
enzyme II shows 6% activity and enzyme III 322% activity compared to 4-aminobutanamide
-
-
?
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
?
-
-
-
?
histamine + H2O + O2
?
-
-
-
?
isoamylamine + H2O + O2
isoamylaldehyde + NH3 + H2O2
-
-
-
-
?
isoamylamine + H2O + O2
isoamylaldehyde + NH3 + H2O2
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
-
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
-
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
-
-
-
r
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
-
-
-
-
?
methylamine + H2O + O2
methanal + NH3 + H2O2
-
-
-
-
?
methylamine + H2O + O2
methanal + NH3 + H2O2
-
-
-
?
methylamine + H2O + O2
methanal + NH3 + H2O2
-
-
-
-
?
methylamine + H2O + O2
methanal + NH3 + H2O2
-
-
-
-
?
methylamine + H2O + O2
methanal + NH3 + H2O2
-
-
-
?
methylamine + H2O + O2
methanal + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]-4-bromobenzamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]-4-bromobenzamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]acetamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]acetamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]propanamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]propanamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
N6-(4-aminobut-2-ynyl)adenine + H2O + O2
?
-
-
-
?
N6-(4-aminobut-2-ynyl)adenine + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
N6-(4-aminobut-2-ynyl)adenine + H2O + O2
?
-
-
-
-
?
N6-(4-aminobut-2-ynyl)adenine + H2O + O2
?
-
-
-
?
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
main substrate for isoform AO2
-
-
?
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
propylamine + H2O + O2
propanal + NH3 + H2O2
-
-
-
-
?
propylamine + H2O + O2
propanal + NH3 + H2O2
-
-
-
?
propylamine + H2O + O2
propanal + NH3 + H2O2
-
-
-
-
?
putrescine + H2O + O2
4-aminobutanal + NH3 + H2O2
-
best substrate
-
-
?
putrescine + H2O + O2
4-aminobutanal + NH3 + H2O2
-
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
best substrate
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
putrescine can be oxidatively deaminated by the enzyme to corresponding aldehyde that spontaneously cyclizes yielding DELTA1-pyrroline
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
best substrate
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
?
spermidine + H2O + O2
?
-
-
-
?
spermidine + H2O + O2
?
-
-
-
?
spermidine + H2O + O2
?
-
-
-
?
spermidine + H2O + O2
?
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2
?
-
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
enzyme II shows 4% activity and enzyme III 175% activity compared to 4-aminobutanamide
-
-
?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
high activity
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
preferred substrate
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylacetaldehyde + NH3 + H2O2
during this reaction, an irreversible inactivation of the enzyme occurs
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
quantum mechanical hydrogen tunneling can be enhanced by an enzyme protein scaffold including the catalytic base that directly mediates the hydrogen transfer
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
high activity
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
additional information
?
-
-
no activity with dopamine, 2-aminoacetic acid, 3-aminopropanoic aid, L-Arg, L-Orn, L-Lys, L-Phe, and D-Lys
-
-
?
additional information
?
-
-
no activity with dopamine, 2-aminoacetic acid, 3-aminopropanoic aid, L-Arg, L-Orn, L-Lys, L-Phe, and D-Lys
-
-
?
additional information
?
-
-
MAO-N is a flavoenzyme that catalyses the oxidative deamination of primary amines, substrate specificity, overview
-
-
?
additional information
?
-
-
MAO-N is an FAD-dependent enzyme that catalyses the conversion of terminal amines to their corresponding aldehyde
-
-
?
additional information
?
-
-
Semicarbazide-sensitive amine oxidase acts as a vascular-adhesion protein, mediating the adhesion of lymphocytes to vascular endothelial cells under inflammatory conditions
-
-
?
additional information
?
-
the catalytic reaction proceeds via two half-reactions; the aldehyde product is released at the end of the reductive half-reaction before reduction of molecular oxygen in the oxidative half-reaction. Mechanism of molecular oxygen entry into the buried active site of the copper amine oxidase, the N-terminal domain does not affect oxygen entry, overview. The protein-derived cofactor TPQ and the off-metal O2-binding site are located in the vicinity of a conserved active-site Met699
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-
?
additional information
?
-
-
the catalytic reaction proceeds via two half-reactions; the aldehyde product is released at the end of the reductive half-reaction before reduction of molecular oxygen in the oxidative half-reaction. Mechanism of molecular oxygen entry into the buried active site of the copper amine oxidase, the N-terminal domain does not affect oxygen entry, overview. The protein-derived cofactor TPQ and the off-metal O2-binding site are located in the vicinity of a conserved active-site Met699
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-
?
additional information
?
-
-
the enzyme can use human granulocytes as a substrate
-
-
?
additional information
?
-
the enzyme oxidizes arginine to ammonia, urea, hydrogen peroxide and glutamate-5-semialdehyde which spontaneously cyclizes yielding DELTA1-pyrroline-5-carboxylic acid
-
-
?
additional information
?
-
-
the enzyme oxidizes arginine to ammonia, urea, hydrogen peroxide and glutamate-5-semialdehyde which spontaneously cyclizes yielding DELTA1-pyrroline-5-carboxylic acid
-
-
?
additional information
?
-
-
physiologic role for SSAO in elastin maturation
-
-
?
additional information
?
-
-
SSAO may contribute to the vascular damage associated to Alzheimers disease
-
-
?
additional information
?
-
synergistic interaction between semicarbazide-sensitive amine oxidase and angiotensin-converting enzyme in diabetes. Semicarbazide-sensitive amine oxidase is involved in the following biological processes: vision, inflammatory response, biogenic amine metabolism, catecholamine metabolism, amine metabolism, cell adhesion
-
-
?
additional information
?
-
semicarbazide-sensitive amine oxidases constitute a group of copper-dependent enzymes, which oxidatively deaminate primary endo- and exogenous amines
-
-
?
additional information
?
-
semicarbazide-sensitive amine oxidases constitute a group of copper-dependent enzymes, which oxidatively deaminate primary endo- and exogenous amines
-
-
?
additional information
?
-
AOC2 is an enzymatically active cell surface SSAO with distinct substrate specificity, the preferred in vitro substrates of AOC2 are 2-phenylethylamine, tryptamine and p-tyramine, cf. EC 1.4.3.4, instead of methylamine and benzylamine, the favored substrates of AOC3. Substrate docking, molecular modeling and comparison of AOC2 and AOC3, overview. No activity of AOC2 with methylamine, polyamine spermidine, or histamine
-
-
?
additional information
?
-
AOC2 is an enzymatically active cell surface SSAO with distinct substrate specificity, the preferred in vitro substrates of AOC2 are 2-phenylethylamine, tryptamine and p-tyramine, cf. EC 1.4.3.4, instead of methylamine and benzylamine, the favored substrates of AOC3. Substrate docking, molecular modeling and comparison of AOC2 and AOC3, overview. No activity of AOC2 with methylamine, polyamine spermidine, or histamine
-
-
?
additional information
?
-
substrate docking, molecular modeling and comparison of AOC2 and AOC3, overview. No activity of AOC3 with polyamine spermidine or histamine
-
-
?
additional information
?
-
substrate docking, molecular modeling and comparison of AOC2 and AOC3, overview. No activity of AOC3 with polyamine spermidine or histamine
-
-
?
additional information
?
-
-
the catalytic center is deeply buried within the enzyme and is accessible only through a narrow channel with a diameter of about 4.5 A. This channel is gated by the side chain of L469 which, along with the copper-TPQ coordination, controls the catalytic activity of SSAO. While specific interactions with residues lining the surface of the accessing channel are important for substrate specificity, the flexibility of substrates also plays an important role, molecular dynamics and induced docking studies, detailed overview
-
-
?
additional information
?
-
VAP-1/SSAOs convert amines into aldehydes. SSAOs are distinct from the mammalian monoamine oxidases, MAOs, but their substrate specificities are partly overlapping
-
-
?
additional information
?
-
-
VAP-1/SSAOs convert amines into aldehydes. SSAOs are distinct from the mammalian monoamine oxidases, MAOs, but their substrate specificities are partly overlapping
-
-
?
additional information
?
-
-
no activity with dimethylamide substituted indole 3-((4-[5-(aminomethyl)-2-fluorophenyl]piperidin-1-yl)carbonyl)-1-(2-methoxyethyl)-N,N-dimethyl-1H-indole-4-carboxamide
-
-
?
additional information
?
-
-
alkylamines 2-bromoethylamine and 2-chloroethylamine, and the short diamine 1,2-diaminoethane are both poor substrates and irreversible inactivators of LSAO
-
-
?
additional information
?
-
-
ethylenediamine and methylamine are no substrates for isoform AO2
-
-
?
additional information
?
-
-
T0901317 inhibits SSAO gene expression and its activity in atherogenic apoE-/- mice. The atheroprotective effect of LXR agonist T0901317 is related to the inhibition of SSAO gene expression and its activity
-
-
?
additional information
?
-
the catalytic mechanism can be divided into two half-reactions: a reductive half-reaction in which a primary amine substrate is oxidized to its corresponding aldehyde with the concomitant reduction of the organic cofactor 2,4,5-trihydroxyphenylalanine quinone and an oxidative half-reaction in which reduced 2,4,5-trihydroxyphenylalanine quinone is re-oxidized with the reduction of molecular oxygen to hydrogen peroxide
-
-
?
additional information
?
-
-
the catalytic mechanism can be divided into two half-reactions: a reductive half-reaction in which a primary amine substrate is oxidized to its corresponding aldehyde with the concomitant reduction of the organic cofactor 2,4,5-trihydroxyphenylalanine quinone and an oxidative half-reaction in which reduced 2,4,5-trihydroxyphenylalanine quinone is re-oxidized with the reduction of molecular oxygen to hydrogen peroxide
-
-
?
additional information
?
-
isoform HPAO-2 shows a clear preference for bulkier aromatic amines and isoform HPAO-1 shows a preference for short aliphatic amines
-
-
?
additional information
?
-
-
isoform HPAO-2 shows a clear preference for bulkier aromatic amines and isoform HPAO-1 shows a preference for short aliphatic amines
-
-
?
additional information
?
-
-
docking of substrates to the enzyme, the enzyme shows electrostatic control of the docking process, overview. The active site contains two negatively charged amino acid residues which seem to interact with positively charged groups of the substrate molecules
-
-
?
additional information
?
-
-
isoform AO1 isolated from butylamine-induced cells with a distinct specificity towards benzylamine (relative to phenylethylamine), acts on a broad range of aliphatic monoamines (C1-C5). Isoform AO2 isolated from phenylethylamine-treated cells displays activity towards phenylethylamine as well as tyramine and heterocyclic amines but negligible conversion of benzylamine and short chain aliphatic amines. Neither AO1 nor AO2 exhibit any measurable activity when using diamines (putrescine or cadaverine) as substrate
-
-
?
additional information
?
-
-
isoform AO1 isolated from butylamine-induced cells with a distinct specificity towards benzylamine (relative to phenylethylamine), acts on a broad range of aliphatic monoamines (C1-C5). Isoform AO2 isolated from phenylethylamine-treated cells displays activity towards phenylethylamine as well as tyramine and heterocyclic amines but negligible conversion of benzylamine and short chain aliphatic amines. Neither AO1 nor AO2 exhibit any measurable activity when using diamines (putrescine or cadaverine) as substrate
-
-
?
additional information
?
-
-
three histidine residues within the C-terminal region of Cao1 that are necessary for amine oxidase activity
-
-
?
additional information
?
-
-
three histidine residues within the C-terminal region of Cao1 that are necessary for amine oxidase activity
-
-
?
additional information
?
-
-
no activity with propylamine and hexylamine
-
-
?