Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.4.3.21: primary-amine oxidase

This is an abbreviated version!
For detailed information about primary-amine oxidase, go to the full flat file.

Word Map on EC 1.4.3.21

Reaction

RCH2NH2
+
H2O
+
O2
=
RCHO
+
NH3
+
H2O2

Synonyms

AGAO, AMAO2, AMAO3, amine oxidase 1, amine oxidase, copper containing, AO1, AO2, AOC2, AOC3, BAO, benzylamine oxidase, bovine plasma amine oxidase, bovine serum amine oxidase, BPAO, BSAO, CAO, Copper amine oxidase, copper amine oxidase 1, copper amine oxidase 8, copper-containing amine oxidase, copper-containing AO, copper-containing monoamine oxidase, copper-dependent amine oxidase, copper/quinone containing amine oxidase, Cu/TPQ amine oxidase, CuAO, CuAO1, CuAO2, CuAO3, CuAO8, EC 1.4.3.6, ECAO, ELAO, GPAO, grass pea amine oxidase, Hansenula polymorpha amine oxidase, HPAO, hPAO-1, HPAO-2, lentil seedling amine oxidase, LSAO, MAO-N, More, OVAO, PAO, pea seedling amine oxidase, plasma amine oxidase, PrAO, primary amine oxidase, primary-amine:oxygen oxidoreductase, PSAO, quinone- and copper-containing amine oxidase, quinone-containing copper amine oxidase, quinone-dependent amine oxidase, quinoprotein copper-containing amine oxidase, RAO, sainfoin amine oxidase, semicarbazide-sensitive amine oxidase, semicarbazide-sensitive amine oxidase/vascular adhesion protein-1, SSAO, SSAO/VAP-1, TPQ-containing CuAO, tynA, tyramine oxidase, copper-requiring, VAP-1, vascular adhesion protein 1, vascular adhesion protein-1

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.21 primary-amine oxidase

Substrates Products

Substrates Products on EC 1.4.3.21 - primary-amine oxidase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1,3-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
1,4-diamino-2-butyne + H2O + O2
?
show the reaction diagram
1,4-diamino-2-chloro-2-butene + H2O + O2
?
show the reaction diagram
1,4-diaminobutane + H2O + O2
?
show the reaction diagram
-
enzyme II shows 23% activity and enzyme III 12% activity compared to 4-aminobutanamide
-
-
?
1,5-diamino-2-pentyne + H2O + O2
?
show the reaction diagram
1,5-diaminopentane + H2O + O2
?
show the reaction diagram
-
enzyme II shows 5% activity and enzyme III 31% activity compared to 4-aminobutanamide
-
-
?
1,6-diamino-2,4-hexadiyne + H2O + O2
?
show the reaction diagram
1,8-diaminooctane + H2O + O2
?
show the reaction diagram
-
-
-
-
?
1-(3-fluoro-4-methylphenyl)methanamine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
1-(4-fluorophenyl)methanamine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
1-aminobutane + H2O + O2
butanal + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
1-aminoheptane + H2O + O2
heptanal + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
1-aminohexane + H2O + O2
hexanal + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
1-aminononane + H2O + O2
nonanal + NH3 + H2O2
show the reaction diagram
-
the aliphatic chain of 1-aminononane induces a shift in the pKa-value of the product Schiff base, the hydrolysis of which appears to be a rate-determining step of the reaction
-
-
?
1-aminooctane + H2O + O2
octanal + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
1-aminopentane + H2O + O2
pentanal + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
1-methyl-3-phenylpropylamine + H2O + O2
4-phenylbutan-2-one + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
1-methylhistamine + O2 + H2O
?
show the reaction diagram
-
-
-
?
2-aminoethylpyridine + H2O + O2
pyridine-2-carbaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
?
2-bromoethylamine + H2O + O2
bromoacetaldehyde + NH3 + H2O2
show the reaction diagram
2-phenylethanamine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
2-phenylethylamine + H2O + O2
2-phenylacetaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
show the reaction diagram
2-phenylethylamine + H2O + O2
?
show the reaction diagram
-
-
-
?
2-phenylethylamine + H2O + O2
beta-phenylethanal + NH3 + H2O2
show the reaction diagram
-
-
-
?
2-phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
show the reaction diagram
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2
?
show the reaction diagram
3-aminomethylpyridine + H2O + O2
pyridine-3-carbaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
?
3-aminopentanamide + H2O + O2
3-oxopentanamide + NH3 + H2O2
show the reaction diagram
-
enzyme II shows 214% activity and enzyme III 11% activity compared to 4-aminobutanamide
-
-
?
3-phenylpropan-1-amine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
4-(aminomethyl)-N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
? + NH3 + H2O2
show the reaction diagram
4-amino-1-butanol + H2O + O2
4-hydroxybutanal + NH3 + H2O2
show the reaction diagram
-
enzyme II shows 525% activity and enzyme III 267% activity compared to 4-aminobutanamide
-
-
?
4-aminobutanamide + H2O + O2
4-oxobutanamide + NH3 + H2O2
show the reaction diagram
-
100% activity
-
-
?
4-aminobutyric acid + H2O + O2
4-oxobutanoate + NH3 + H2O2
show the reaction diagram
-
enzyme II shows no activity and enzyme III 10% activity compared to 4-aminobutanamide
-
-
?
4-aminomethylpyridine + H2O + O2
pyridine-4-carbaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2
?
show the reaction diagram
4-fluorobenzylamine + H2O + O2
4-fluorobenzaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
4-N,N-dimethylaminomethyl benzylamine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
4-phenylbutan-1-amine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
show the reaction diagram
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
?
5-amino-1-pentanol + H2O + O2
5-hydroxypentanal + NH3 + H2O2
show the reaction diagram
-
enzyme II shows 86% activity and enzyme III 388% activity compared to 4-aminobutanamide
-
-
?
5-aminopentanoic acid + H2O + O2
5-oxopentanoate + NH3 + H2O2
show the reaction diagram
-
enzyme II shows 3% activity and enzyme III 7% activity compared to 4-aminobutanamide
-
-
?
5-hydroxytryptamine + H2O + O2
?
show the reaction diagram
agmatine + H2O + O2
?
show the reaction diagram
-
-
-
?
allyl [3-(aminomethyl)benzyl]carbamate + H2O + O2
? + NH3 + H2O2
show the reaction diagram
alpha-casein + H2O + O2
?
show the reaction diagram
-
the enzyme oxidizes the lysine residues in alpha-casein protein
-
-
?
aminoacetone + H2O + O2
methylglyoxal + NH3 + H2O2
show the reaction diagram
amphetamine + H2O + O2
1-phenylpropan-2-one + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
amylamine + H2O + O2
pentanal + NH3 + H2O2
show the reaction diagram
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
show the reaction diagram
benzylamine + O2 + H2O
benzaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
?
beta-phenylethylamine + H2O + O2
beta-phenylethanal + NH3 + H2O2
show the reaction diagram
-
-
-
?
beta-phenylethylamine + O2 + H2O
beta-phenylethanal + NH3 + H2O2
show the reaction diagram
-
-
-
?
butylamine + H2O + O2
butanal + NH3 + H2O2
show the reaction diagram
cadaverine + H2O + O2
?
show the reaction diagram
cadaverine + H2O + O2
DELTA1-piperideine + NH3 + H2O2
show the reaction diagram
best substrate
-
-
?
cyclohexanemethylamine + H2O + O2
cyclohexanecarbaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
?
cysteamine + H2O + O2
sulfanylacetaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
show the reaction diagram
dopamine + H2O + O2
?
show the reaction diagram
-
-
-
?
ethanolamine + H2O + O2
glycolaldehyde + NH3 + H2O2
show the reaction diagram
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
show the reaction diagram
ethylamine + H2O + O2
ethanal + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
hexakis(benzylammonium) decavanadate (V) dihydrate + H2O + O2
?
show the reaction diagram
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
show the reaction diagram
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
show the reaction diagram
histamine + H2O + O2
?
show the reaction diagram
isoamylamine + H2O + O2
isoamylaldehyde + NH3 + H2O2
show the reaction diagram
isobutylamine + H2O + O2
isobutyraldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
?
isopentylamine + H2O + O2
isopentylaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
methyl 1-(2-methoxyethyl)-3-(trifluoroacetyl)-1H-indole-4-carboxylate + H2O + O2
?
show the reaction diagram
-
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
show the reaction diagram
methylamine + H2O + O2
methanal + NH3 + H2O2
show the reaction diagram
methylbenzylamine + H2O + O2
methylbenzaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
n-butylamine + H2O + O2
butanal + NH3 + H2O2
show the reaction diagram
-
enzyme II shows 368% activity and enzyme III 454% activity compared to 4-aminobutanamide
-
-
?
n-hexylamine + H2O + O2
hexanal + NH3 + H2O2
show the reaction diagram
-
enzyme II shows 244% activity and enzyme III 589% activity compared to 4-aminobutanamide
-
-
?
n-pentylamine + H2O + O2
pentanal + NH3 + H2O2
show the reaction diagram
-
enzyme II shows 314% activity and enzyme III 596% activity compared to 4-aminobutanamide
-
-
?
n-propylamine + H2O + O2
propanal + NH3 + H2O2
show the reaction diagram
-
enzyme II shows 515% activity and enzyme III 201% activity compared to 4-aminobutanamide
-
-
?
N-[3-(aminomethyl)benzyl]-4-bromobenzamide + H2O + O2
? + NH3 + H2O2
show the reaction diagram
N-[3-(aminomethyl)benzyl]acetamide + H2O + O2
? + NH3 + H2O2
show the reaction diagram
N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
? + NH3 + H2O2
show the reaction diagram
N-[3-(aminomethyl)benzyl]propanamide + H2O + O2
? + NH3 + H2O2
show the reaction diagram
N6-(4-aminobut-2-ynyl)adenine + H2O + O2
?
show the reaction diagram
Nalpha-benzyloxycarbony-L-lysine + H2O + O2
?
show the reaction diagram
-
enzyme II shows 3% activity and enzyme III 12% activity compared to 4-aminobutanamide
-
-
?
Nalpha-Z-D-lysine + H2O + O2
?
show the reaction diagram
-
enzyme II shows no activity and enzyme III 10% activity compared to 4-aminobutanamide
-
-
?
octopamine + H2O + O2
hydroxy(hydroxyphenyl)acetaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
ornithine + H2O + O2
?
show the reaction diagram
ornithine can be transformed in glutamate-5-semialdehyde spontaneously cyclizes yielding DELTA1-pyrroline-5-carboxylic acid
-
-
?
phenethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
?
phenylethyl amine + H2O + O2
phenylethanal + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
show the reaction diagram
propylamine + H2O + O2
propanal + NH3 + H2O2
show the reaction diagram
putrescine + H2O + O2
4-aminobutanal + NH3 + H2O2
show the reaction diagram
putrescine + H2O + O2
4-aminobutyraldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
putrescine + H2O + O2
?
show the reaction diagram
pyrrolidine + 2,4,5-trihydroxyphenylalanine quinone + H2O + O2
? + H2O2 + NH3
show the reaction diagram
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
show the reaction diagram
sec-butylamine + H2O + O2
butan-2-one + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
serotonin + O2 + H2O
(5-hydroxy-1H-indol-3yl)acetaldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
?
spermidine + H2O + O2
?
show the reaction diagram
spermidine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
good substrate. The oxidation of spermidine yields to the liberation of ammonia, hydrogen peroxide and the corresponding aldehyde that spontaneously cyclizes yielding first 1-(3-aminopropyl)pyrroliniun and, thereafter, 1,5-diazobicyclononane
-
-
?
spermine + H2O + O2
?
show the reaction diagram
spermine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
good substrate
-
-
?
tropoelastin + H2O + O2
?
show the reaction diagram
-
the enzyme oxidizes the lysine residues in tropoelastin protein
-
-
?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
show the reaction diagram
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
show the reaction diagram
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
show the reaction diagram
tyramine + H2O + O2
4-hydroxyphenylacetaldehyde + NH3 + H2O2
show the reaction diagram
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
show the reaction diagram
tyramine + H2O + O2
?
show the reaction diagram
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
tyramine + O2 + H2O
4-hydroxyphenylethanal + NH3 + H2O2
show the reaction diagram
-
-
-
?
vanillylamine + H2O + O2
vanillic aldehyde + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
additional information
?
-