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1.4.3.2: L-amino-acid oxidase

This is an abbreviated version!
For detailed information about L-amino-acid oxidase, go to the full flat file.

Word Map on EC 1.4.3.2

Reaction

an L-amino acid
+
H2O
 +
O2
=
a 2-oxo carboxylate
 +
NH3
 +
H2O2

Synonyms

AAD, ACTX-6, ACTX-8, Akbu-LAAO, APIT, apotxin, aromatic L-amino acid oxidase, Balt-LAAO-I, bordonein-L, Bpir-LAOO-1, CC-LPOX, DAA, Dolabellanin, escapin, head kidney and gill, IL4I1, Il4i1 protein, ink toxin 1, Interleukin Four Induced Gene 1 protein, L-AAO, L-AAO/MOG, L-AAO1, L-amino acid oxidase, L-amino acid: O2 oxidoreductase, L-amino acid:O2 oxidoreductase, L-amino acid:O2 oxidoreductase (deaminating), L-aminooxidase, L-Aox, L-phenylalanine oxidase, LAAO, LAAO-1, LAAO-I, LAAO-II, LAAO1, LAAO4, LAAOI, LAAOII, LAO, LAO1, M-LAO, ophio-amino-acid oxidase, Pm1, RoLAAO, sarA, Sebastes schlegeli antibacterial protein, Sebastes schlegelii antibacterial protein, SSAP, TJ-LAO, toxophallin, TSV-LAO

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.2 L-amino-acid oxidase

Inhibitors

Inhibitors on EC 1.4.3.2 - L-amino-acid oxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
complete inhibition of isoform LAAOII and about 30% inhibition of isoform LAAOI at 5 mM
2-aminobenzoic acid
-
three and two binding sites in isoforms L1 and L2, respectively
2-mercaptoethanol
6-chloro-8-methoxy-6,11a-dihydro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
derivative of aristolochic acid, significantly inhibits catalytic activity and reduces LAAO-induced cytotoxicity, interferes with the binding of LAAO to the cell membrane but does not interact with DNA. The derivative significantly reduces LAAO-induced ROS generation and cytotoxicity in HEK-293 and HepG2 cell lines
-
6-hydroxy-8-methoxy-6,11a-dihydro-2H-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid
derivative of aristolochic acid, significantly inhibits catalytic activity and reduces LAAO-induced cytotoxicity, interferes with the binding of LAAO to the cell membrane but does not interact with DNA. The derivative significantly reduces LAAO-induced ROS generation and cytotoxicity in HEK-293 and HepG2 cell lines
-
8-hydroxyquinoline
Al3+
strong inhibition of both isoforms at 10 mM
alpha,alpha'-dipyridyl
-
15% residual activity at 1 mM
alpha-methyl-L-tyrosine
mixed type inhibitor
alpha-Naphthol
-
12.4% inhibition at 10 mM
anthranilate
aristolochic acid
reversible, mixed inhibition
aromatic carboxylates
-
competitive
Atebrine
bathophenanthroline disulfonic acid
-
-
Benzenearsonic acid
-
-
benzoate
benzoic acid
Butanedione
snake
-
good substrates but not poor substrates protect against inactivation
CaCl2
Chloropromazine
-
inhibition can be relieved by L-arginine
Cr3+
slight inhibition
CTAB
strong inhibition
D-mandelate
-
-
DTT
slight inhibition
EMD 132338
-
inhibits platelet aggregation induced by LAAO
FAD
activates at 0.002 mM, inhibits at 0.004-0.008 mM
Gd3+
-
inhibits 17% at 10 mM
glutathione
-
glycine
hydrazine
hydroxylamine
iodoacetate
iodoacetic acid
L-arginine
pH 7.6, 30°C
L-citrulline
pH 7.6, 30°C
L-cysteine
complete inhibition of both isoforms at 5 mM
L-leucine
pH 7.6, 30°C
L-lysine
pH 7.6, 30°C
L-Mandelate
-
-
L-methionine
pH 7.6, 30°C
L-norleucine
pH 7.6, 30°C
L-ornithine
pH 7.6, 30°C
L-phenylalanine
pH 7.6, 30°C
L-propargylglycine
L-serine
pH 7.6, 30°C
L-tyrosine
pH 7.6, 30°C
Li+
slight inhibition
m-Aminobenzoate
-
-
m-chlorobenzoate
m-fluorobenzoate
-
-
m-Hydroxybenzoate
-
-
m-Nitrobenzoate
-
-
Mandelate
-
-
N-acetyl-L-tryptophan
-
about 90% inhibition at 50 nM
N-acetyl-L-tryptophan amide
-
inhibition of both isoforms L1 and L2
N-acetyltryptophan
-
inhibition of both isoforms L1 and L2
N-ethylmaleimide
-
87% residual activity at 1 mM
N-methyl-L-tyrosine
competitive inhibitor
Na+
-
sodium salts, order of effectiveness: SCN-, NO3-, Cl-, Br-, I-, F-, HCOO-, CH3COO-
NaF
-
10 mM, 85% inhibition
NaN3
-
91% residual activity at 1 mM
o-aminobenzoate
-
-
o-aminobenzoic acid
LAO inhibitor, slightly inhibiting the degradation of fibrinogen
o-chlorobenzoate
-
-
o-fluorobenzoate
-
-
o-hydroxybenzoate
-
-
o-mercaptobenzoate
-
-
o-Nitrobenzoate
-
-
o-phenanthroline
orthanilic acid
-
-
p-Aminobenzoate
-
-
p-Aminobenzoic acid
-
-
p-Chlorobenzoate
-
-
p-chloromercuribenzoate
p-fluorobenzoate
-
-
p-hydroxybenzoate
-
-
p-nitrobenzoate
-
-
Pepsin
10 mg/ml, complete inhibition
-
phenylhydrazine
-
complete inhibition at 1 mM (pH 5.5)
phenylmethylsulfonyl fluoride
about 20% inhibition of isoform LAAOII and about 90% inhibition of isoform LAAOI at 5 mM
proteinase K
10 mg/ml, complete inhibition
-
quinine sulfate
reduced glutathione
complete inhibition of both isoforms at 5 mM
riboflavin
-
44.89% inhibition at 10 mM
Semicarbazide
Sodium azide
Thiosemicarbazide
-
5 mM, 40% inhibition
Trypsin
10 mg/ml, complete inhibition
-
tunicamycin
-
inhibits secretion of recombinant LAAO
Urea
about 50% inhibition of isoform LAAOII and about 20% inhibition of isoform LAAOI at 5 mM
Vinylglycine
-
-
additional information
-