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1.4.1.9: leucine dehydrogenase

This is an abbreviated version!
For detailed information about leucine dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.9

Reaction

L-leucine
+
H2O
 +
NAD+
=
4-methyl-2-oxopentanoate
 +
NH3
 +
NADH
 +
H+

Synonyms

BCD, dehydrogenase, leucine, L-leucine dehydrogenase, L-leucine:NAD+ oxidoreductase, deaminating, LeuDH

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.9 leucine dehydrogenase

Inhibitors

Inhibitors on EC 1.4.1.9 - leucine dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4-methyl-2-pentanone
-
competitive inhibition of wild-type enzyme, noncompetitive inhibition of mutant enzyme K80A
4-methylpentanoate
Ag+
-
1 mM, no residual activity
AgNO3
-
1 mM, complete
Cd2+
1 mM, 8% residual activity
Cr2+
1 mM, 13% residual activity
Cu(CH3COO)2
-
1 mM, 20% inhibition
D-2-aminobutanoate
-
-
D-alloisoleucine
-
-
EDTA
1 mM, 92% residual activity
Fe2+
1 mM, 75% residual activity
Fe3+
-
1 mM, no residual activity
Hg2+
1 mM, 29% residual activity
HgCl2
KCl
-
0.5 M, specific activity 133 U/mg
KCN
-
1 mM, 43% inhibition
L-Leu
-
competitive inhibition of the reductive amination of 4-methylthio-2-oxobutanoate
NaCl
-
0.5 M, specific activity 152 U/mg
NAD+
-
product inhibition
NH4+
-
inhibits oxidative deamination
p-mercuribenzoate
Pb(CH3COO)2
-
1 mM, 20% inhibition
Pb2+
1 mM, no residual activity
pyridoxal 5'-phosphate
Sulfide
Thiourea
1 mM, 52% residual activity
Zn2+
1 mM, 80% residual activity
additional information
-
not inhibitory: EDTA, Ca2+, Mg2+
-