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1.4.1.7: serine 2-dehydrogenase

This is an abbreviated version!
For detailed information about serine 2-dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.7

Reaction

L-serine
+
H2O
+
NAD+
=
3-hydroxypyruvate
+
NH3
+
NADH
+
H+

Synonyms

L-serine:NAD oxidoreductase (deaminating), NAD+-dependent L-serine dehydrogenase, protein PA0743, serine dehydrogenase

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.7 serine 2-dehydrogenase

General Information

General Information on EC 1.4.1.7 - serine 2-dehydrogenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
the enzyme has an N-terminal Rossmann fold domain connected by a long alpha-helix to the C-terminal all-alpha domain. Critical role of four amino acid residues in catalysis including the primary catalytic residue Lys171, PA0743 substrate-binding site structure and molecular mechanisms of substrate selectivity, overview. The structure of the PA0743-NAD+ complex demonstrates that the opposite side of the enzyme active site accommodates the cofactor, which is also bound near Lys171