1.4.1.4: glutamate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about glutamate dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

APE1386, BpNADPGDH I, BpNADPGDH II, dehydrogenase, glutamate (nicotinamide adenine dinucleotide phosphate), EcGDH, GDH, GDH1, Gdh1p, GDH2, GDH3, Gdh3p, GDH4, GdhA, GDHB, GDHC, GDHI, GDHI', GDHII, GDHP, GluDH, glutamate dehydrogenase, glutamate dehydrogenase 1, glutamate dehydrogenase 2, glutamate dehydrogenase 3, glutamic acid dehydrogenase, glutamic dehydrogenase, GW612_14215, H-form specific BpNADPGDH II, hGDH, hyphal-form specific BpNADPGDH II, L-glutamate dehydrogenase, NAD(P)H-dependent glutamate dehydrogenase, NADP(+)-dependent glutamate dehydrogenase, NADP(H)-dependent glutamate dehydrogenase, NADP(H)-GDH, NADP(H)-specific glutamate dehydrogenase, NADP+ - dependant-glutamate dehydrogenase, NADP+-dependent GDH, NADP+-dependent glutamate dehydrogenase, NADP+-Gdh, NADP-dependent GDH, NADP-dependent GluDH, NADP-dependent glutamate dehydrogenase, NADP-dependent glutamate dehydrogenase 1, NADP-dependent glutamate dehydrogenase 2, NADP-GDH, NADP-GDH 1, NADP-GDH 2, NADP-glutamate dehydrogenase, NADP-linked glutamate dehydrogenase, NADP-specific glutamate dehydrogenase, NADP-specific L-glutamate dehydrogenase, NADP-ylGdh1p, NADPH-dependent GDH, NADPH-dependent glutamate dehydrogenase, OsGDH4, Pcal_1606, RocG, TrGDH, Y-form specific BpNADPGDH I, YALI0F17820g, yeast-form specific BpNADPGDH I, ylGDH1

ECTree

     1 Oxidoreductases

         1.4 Acting on the CH-NH₂ group of donors

             1.4.1 With NAD⁺ or NADP⁺ as acceptor

                1.4.1.4 glutamate dehydrogenase (NADP+)

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Results	in table
49	Activating Compound
1257	AA Sequence
21	Application
1	CAS Registry Number
41	Cloned(Commentary)
229	Cofactor
15	Crystallization (Commentary)
7	Disease/ Diagnostics
15	Expression
61	General Information
22	General Stability
46	IC50 Value
151	Inhibitors
47	kcat/KM [mM/s]
17	Ki Value [mM]
345	KM Value [mM]
13	Localization
13	Metals/Ions
109	Molecular Weight [Da]
129	Natural Substrates/ Products (Substrates)
4	Organic Solvent Stability
389	Organism
8	Pathway
42	PDB ID
112	pH Optimum
8	pH Range
9	pH Stability
3	pI Value
7	Posttranslational Modification
72	Protein Variants
55	Purification (Commentary)
1	Reaction
5	Reaction Type
235	Reference
49	Source Tissue
74	Specific Activity [micromol/min/mg]
25	Storage Stability
382	Substrates and Products (Substrate)
97	Subunits
247	Synonyms
1	Systematic Name
63	Temperature Optimum [°C]
8	Temperature Range [°C]
88	Temperature Stability [°C]
60	Turnover Number [1/s]

Expression

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Expression on EC 1.4.1.4 - glutamate dehydrogenase (NADP+)

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

during logarithmic growth on rich medium, the NADP-ylGDH1p enzyme activity is most highly expressed and induced in stationary and nitrogen starved cells by 3fold to 12fold

3 entries

enzyme expression is upregulated under N2-starvation, overview

Mycolicibacterium smegmatis

A0R3E3

711601

GDH expression of strain DPPMA49 is downregulated by temperature below 13�C, expression analysis

2 entries

GDH expression of strain DPPMA49 is upregulated by NaCl at 1.87-5.62%

2 entries

presence of leucine regulates the levels of NADP-GDH activity and gdhA expression. Leucine regulation of gdhA requires a functional LeuB with an intact Zn(II)2Cys6 DNA-binding domain

2 entries

replacement of ammonia with glutamate in growth medium causes a decrease in NADP-ylGdh1p activity

3 entries

the regulation of GDH1 under glucose conditions is performed by nitrogen catabolite repressor (NCR)-sensitive activators, Leu3p and activators exclusive for respiratory growth such as the HAP complex that coordinates nuclear and mitochondrial gene expression. Under ethanol conditions, GDH1 derepression is mediated by the Gcn4 and Hap4 transcriptional activators and is amplified by Gln3

2 entries

during logarithmic growth on rich medium, the NADP-ylGDH1p enzyme activity is most highly expressed and induced in stationary and nitrogen starved cells by 3fold to 12fold

Yarrowia lipolytica

Q6C1A9

763775

during logarithmic growth on rich medium, the NADP-ylGDH1p enzyme activity is most highly expressed and induced in stationary and nitrogen starved cells by 3fold to 12fold

Yarrowia lipolytica CLIB 122

-

-

during logarithmic growth on rich medium, the NADP-ylGDH1p enzyme activity is most highly expressed and induced in stationary and nitrogen starved cells by 3fold to 12fold

Yarrowia lipolytica E 150

-

-

GDH expression of strain DPPMA49 is downregulated by temperature below 13�C, expression analysis

Lactiplantibacillus plantarum

Q2WCS9

712263

GDH expression of strain DPPMA49 is downregulated by temperature below 13�C, expression analysis

Lactiplantibacillus plantarum DPPMA49

-

-

GDH expression of strain DPPMA49 is upregulated by NaCl at 1.87-5.62%

Lactiplantibacillus plantarum

Q2WCS9

712263

GDH expression of strain DPPMA49 is upregulated by NaCl at 1.87-5.62%

Lactiplantibacillus plantarum DPPMA49

-

-

presence of leucine regulates the levels of NADP-GDH activity and gdhA expression. Leucine regulation of gdhA requires a functional LeuB with an intact Zn(II)2Cys6 DNA-binding domain

Aspergillus nidulans

P18819

743246

presence of leucine regulates the levels of NADP-GDH activity and gdhA expression. Leucine regulation of gdhA requires a functional LeuB with an intact Zn(II)2Cys6 DNA-binding domain

Aspergillus nidulans ATCC 38163

-

-

replacement of ammonia with glutamate in growth medium causes a decrease in NADP-ylGdh1p activity

Yarrowia lipolytica

Q6C1A9

763775

replacement of ammonia with glutamate in growth medium causes a decrease in NADP-ylGdh1p activity

Yarrowia lipolytica CLIB 122

-

-

replacement of ammonia with glutamate in growth medium causes a decrease in NADP-ylGdh1p activity

Yarrowia lipolytica E 150

-

-

the regulation of GDH1 under glucose conditions is performed by nitrogen catabolite repressor (NCR)-sensitive activators, Leu3p and activators exclusive for respiratory growth such as the HAP complex that coordinates nuclear and mitochondrial gene expression. Under ethanol conditions, GDH1 derepression is mediated by the Gcn4 and Hap4 transcriptional activators and is amplified by Gln3

Saccharomyces cerevisiae

P07262, P39708

763438

the regulation of GDH1 under glucose conditions is performed by nitrogen catabolite repressor (NCR)-sensitive activators, Leu3p and activators exclusive for respiratory growth such as the HAP complex that coordinates nuclear and mitochondrial gene expression. Under ethanol conditions, GDH1 derepression is mediated by the Gcn4 and Hap4 transcriptional activators and is amplified by Gln3

Saccharomyces cerevisiae ATCC 204508

-

-