1.4.1.21: aspartate dehydrogenase

This is an abbreviated version!
For detailed information about aspartate dehydrogenase, go to the full flat file.

Reaction

Synonyms

AspDH, L-aspartate dehydrogenase, L-aspartate:NAD(P)+ oxidoreductase (deaminating), L-aspDH, NAD-dependent aspartate dehydrogenase, NADH2-dependent aspartate dehydrogenase, NADP+-dependent aspartate dehydrogenase, nadX

ECTree

     1 Oxidoreductases

         1.4 Acting on the CH-NH₂ group of donors

             1.4.1 With NAD⁺ or NADP⁺ as acceptor

                1.4.1.21 aspartate dehydrogenase

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Results	in table
1	Activating Compound
4875	AA Sequence
19	Application
1	CAS Registry Number
14	Cloned(Commentary)
58	Cofactor
2	Crystallization (Commentary)
31	General Information
2	General Stability
4	Inhibitors
26	kcat/KM [mM/s]
2	Ki Value [mM]
74	KM Value [mM]
14	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
54	Organism
4	Pathway
2	PDB ID
19	pH Optimum
2	pH Range
4	pH Stability
4	Protein Variants
9	Purification (Commentary)
3	Reaction
3	Reaction Type
25	Reference
20	Specific Activity [micromol/min/mg]
1	Storage Stability
110	Substrates and Products (Substrate)
29	Subunits
44	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
3	Temperature Range [°C]
22	Temperature Stability [°C]
34	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.4.1.21 - aspartate dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

L-aspartate:NAD(P)+ oxidoreductase (2-iminosuccinate-forming)

The enzyme is strictly specific for L-aspartate as substrate. It produces the unstable compound 2-iminosuccinate, which, in the presence of water, hydrolyses spontaneously to form oxaloacetate. The enzyme from some archaea and thermophilic bacteria is likely to transfer 2-iminosuccinate directly to EC 2.5.1.72, quinolinate synthase, preventing its hydrolysis and enabling the de novo biosynthesis of NAD+.