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1.4.1.20: phenylalanine dehydrogenase

This is an abbreviated version!
For detailed information about phenylalanine dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.20

Reaction

L-phenylalanine
+
H2O
+
NAD+
=
phenylpyruvate
+
NH3
+
NADH
+
H+

Synonyms

dehydrogenase, phenylalanine, L-PheDH, L-phenylalanine dehydrogenase, L-phenylalanine:NAD+ oxidoreductase, deaminating, PDH, PHD, PheDH, phenylalanine dehydrogenase, recombinant PheDH, recombinant phenylalanine dehydrogenase

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.20 phenylalanine dehydrogenase

Inhibitors

Inhibitors on EC 1.4.1.20 - phenylalanine dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
3-Phenylpropionate
-
competitive with L-Phe
4-hydroxyphenylethylamine
-
competitive with L-Phe
5,5'-dithio-bis(2-nitrobenzoic acid)
acetonitrile
in the presence of acetonitrile at 10% (v/v), the enzyme retains about 60% of the original activity. However, the enzyme exhibits nearly no activity in the presence of acetonitrile at 30% (v/v)
AgNO3
alpha-methyl-DL-phenylalanine
-
-
Cu2+
-
slight
D-ethionine
-
-
D-Leu
D-Met
D-norleucine
D-Phe
D-Trp
D-Tyr
D-Val
-
10 mM, 11% inhibition
HgCl2
Isopropanol
in the presence of isopropanol at 10% (v/v), the enzyme retains about 30% of the original activity. However, the enzyme exhibits nearly no activity in the presence of isopropanol at 30% (v/v)
L-Cys
-
10 mM, 41% inhibition
L-Ile
-
10 mM, 75% inhibition
L-Leu
L-Phe
L-phenylglycine
-
competitive with L-Phe
L-Phenyllactate
-
-
L-Val
-
10 mM, 23% inhibition
methyl acetyl phosphate
-
irreversible inactivation, simultaneous addition of substrate and coenzyme markedly protect from inactivation, the reagent can acetylate Lys69 and Lys81
NEM
-
1 mM: 79% inhibition
phenylenediamine
-
-
Phenylethylamine
phenylpropionate
-
-
phenylpyruvate
-
-
trans-cinnamate
additional information
the enzyme exhibits nearly no change on enzyme activity in the presence of glycol, ethanol and methanol at 10% (v/v)
-