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1.4.1.18: lysine 6-dehydrogenase

This is an abbreviated version!
For detailed information about lysine 6-dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.18

Reaction

L-lysine
+
NAD+
+
H2O
=
(S)-2-amino-6-oxohexanoate
+
NADH
+
H+
+
NH3

Synonyms

L-lysine 6-dehydrogenase, L-lysine 6-dehydrogenase (deaminating), L-lysine epsilon-dehydrogenase, Lys 6-DH, LysDH, lysine 6-dehydrogenase

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.18 lysine 6-dehydrogenase

Substrates Products

Substrates Products on EC 1.4.1.18 - lysine 6-dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-2-aminoadipate 6-semialdehyde
(S)-2,3,4,5-tetrahydropiperidine-2-carboxylate + H2O
show the reaction diagram
1-phenylbutan-1-one + NADH + H+ + NH3
(1R)-1-phenylbutan-1-amine + NAD+ + H2O
show the reaction diagram
mutant F173A, 10 mM, 87% conversion, product in R-configuration, 99.8% ee
-
-
?
1-phenylethan-1-one + NADH + H+ + NH3
(1R)-1-phenylethan-1-amine + NAD+ + H2O
show the reaction diagram
mutant F173A, 10 mM, 99% conversion, product in R-configuration, 99.9% ee
-
-
?
1-phenylpentan-1-one + NADH + H+ + NH3
1-phenylpentan-1-amine + NAD+ + H2O
show the reaction diagram
mutant F173A, 10 mM, 36% conversion
-
-
?
1-phenylpropan-1-one + NADH + H+ + NH3
(1R)-1-phenylpropan-1-amine + NAD+ + H2O
show the reaction diagram
mutant F173A, 10 mM, 98% conversion, product in R-configuration, 99.9% ee
-
-
?
2,3-dihydro-4H-1-benzopyran-4-one + NADH + H+ + NH3
(4R)-3,4-dihydro-2H-1-benzopyran-4-amine + NAD+ + H2O
show the reaction diagram
mutant F173A, 10 mM, 82% conversion, product in R-configuration, 99.4% ee
-
-
?
3,4-dihydronaphthalen-1(2H)-one + NADH + H+ + NH3
(1R)-1,2,3,4-tetrahydronaphthalen-1-amine + NAD+ + H2O
show the reaction diagram
mutant F173A, 10 mM, 79% conversion, product in R-configuration, 99% ee
-
-
?
4-methylpentan-2-one + NADH + H+ + NH3
(2R)-4-methylpentan-2-amine + NAD+ + H2O
show the reaction diagram
mutant F173A, 10 mM, 76% conversion, product in R-configuration, 97% ee
-
-
?
6-oxoheptanoic acid + NADH + H+ + NH3
(6S)-6-aminoheptanoic acid + NAD+ + H2O
show the reaction diagram
mutant F173A, 10 mM, 99% conversion, product in S-configuration, 99% ee
-
-
?
6-oxohexanoic acid + NADH + H+ + NH3
L-lysine + NAD+ + H2O
show the reaction diagram
mutant F173A, 10 mM, 99% conversion
-
-
?
cyclohexanone + NADH + H+ + NH3
cyclohexanamine + NAD+ + H2O
show the reaction diagram
mutant F173A, 10 mM, 86% conversion
-
-
?
hexan-2-one + NADH + H+ + NH3
(2R)-hexan-2-amine + NAD+ + H2O
show the reaction diagram
mutant F173A, 10 mM, 87% conversion, product in R-configuration, 99% ee
-
-
?
L-lysine + 3-acetylpyridine-NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + 3-acetylpyridine-NADH
show the reaction diagram
L-lysine + deamino-NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + deamino-NADH
show the reaction diagram
L-lysine + NAD(P)+ + H2O
(S)-2-aminoadipate 6-semialdehyde + NAD(P)H + H+ + NH3
show the reaction diagram
L-lysine + NAD+ + H2O
(S)-2-amino-6-oxohexanoate + NADH + H+ + NH3
show the reaction diagram
L-lysine + NAD+ + H2O
2-aminoadipate-6-semialdehyde + NADH + H+ + NH3
show the reaction diagram
-
cyclizes nonenzymatically to DELTA1-piperidine-6-carboxylate
-
?
L-lysine + NAD+ + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + NADH
show the reaction diagram
L-lysine + NADP+
2-aminoadipate-6-semialdehyde + NADPH
show the reaction diagram
22% of activity with NAD+
cyclizes nonenzymatically to DELTA1-piperidine-6-carboxylate
-
?
L-lysine + nicotinamide guanine dinucleotide + H2O
alpha-aminoadipate delta-semialdehyde + NH3 + nicotinamide guanine dinucleotide
show the reaction diagram
-
-
-
?
pentan-2-one + NADH + H+ + NH3
(2R)-pentan-2-amine + NAD+ + H2O
show the reaction diagram
mutant F173A, 10 mM, 86% conversion, product in R-configuration, 89% ee
-
-
?
S-(beta-aminoethyl)-L-cysteine + NAD+
?
show the reaction diagram
additional information
?
-