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1.4.1.18: lysine 6-dehydrogenase

This is an abbreviated version!
For detailed information about lysine 6-dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.18

Reaction

L-lysine
+
NAD+
+
H2O
=
(S)-2-amino-6-oxohexanoate
+
NADH
+
H+
+
NH3

Synonyms

L-lysine 6-dehydrogenase, L-lysine 6-dehydrogenase (deaminating), L-lysine epsilon-dehydrogenase, Lys 6-DH, LysDH, lysine 6-dehydrogenase

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.18 lysine 6-dehydrogenase

Reference

Reference on EC 1.4.1.18 - lysine 6-dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Misono, H.; Nagasaki, S.
Occurrence of L-lysine epsilon-dehydrogenase in Agrobacterium tumefaciens
J. Bacteriol.
150
398-401
1982
Agrobacterium tumefaciens
Manually annotated by BRENDA team
Misono, H.; Nagasaki, S.
Distribution and physiological function of L-lysine epsilon-dehydrogenase
Agric. Biol. Chem.
47
631-633
1983
Agrobacterium tumefaciens, Alcaligenes faecalis, Sinomonas atrocyanea, Lysinibacillus sphaericus, Corynebacterium ammoniagenes, Corynebacterium pseudodiphtheriticum, Hafnia alvei, Klebsiella pneumoniae, Micrococcus sp., Morganella morganii, no activity in Bos taurus, no activity in yeast, Pseudomonas fragi
-
Manually annotated by BRENDA team
Misono, H.; Uehigashi, H.; Morimoto, E.; Nagasaki, S.
Purification and properties of L-lysine epsilon-deydrogenase from Agrobacterium tumefaciens
Agric. Biol. Chem.
49
2253-2255
1985
Agrobacterium tumefaciens
Manually annotated by BRENDA team
Esbolsev, E.O.; Klyschev, L.K.; Frantsev, A.P.
The enzymatic properties of biosythesis of piperidine nucleus of alkaloids from lysine
F. E. C. S. (Int. Conf. Chem. Biotechnol. Biol. Act. Nat. Prod. , 3rd. , Meeting Date 1985) VCH Weinheim
5
60-64
1987
Anabasis aphylla
-
Manually annotated by BRENDA team
Hashimoto, H.; Misono, H.; Nagata, S.; Nagasaki, S.
Stereospecificity of hydrogen transfer of the coenzyme catalyzed by L-lysine epsilon-dehydrogenase
Agric. Biol. Chem.
53
1175-1176
1989
Agrobacterium tumefaciens
-
Manually annotated by BRENDA team
Misono, H.; Hashimoto, H.; Uehigashi, H.; Nagata, S.; Nagasaki, S.
Properties of L-lysine epsilon-dehydrogenase from Agrobacterium tumefaciens
J. Biochem.
105
1002-1008
1989
Agrobacterium tumefaciens
Manually annotated by BRENDA team
Hashimoto, H.; Misono, H.; Nagata, S.; Nagasaki, S.
Activation of L-lysine epsilon-dehydrogenase from Agrobacterium tumefaciens by several amino acids and monocarboxylates
J. Biochem.
106
76-80
1989
Agrobacterium tumefaciens
Manually annotated by BRENDA team
Hashimoto, H.; Misono, H.; Nagata, S.; Nagasaki, S.
Selective determination of L-lysine with L-lysine epsilon dehydrogenase
Agric. Biol. Chem.
54
291-294
1990
Agrobacterium tumefaciens
Manually annotated by BRENDA team
Misono, H.; Yoshimura, T.; Nagasaki, S.; Soda, K.
Stereospecific abstraction of epsilon-pro-R-hydrogen of L-lysine by L-lysine epsilon-dehydrogenase from Agrobacterium tumefaciens
J. Biochem.
107
169-172
1990
Agrobacterium tumefaciens
Manually annotated by BRENDA team
Heydari, M.; Ohshima, T.; Nunoura-Kominato, N.; Sakuraba, H.
Highly stable L-lysine 6-dehydrogenase from the thermophile Geobacillus stearothermophilus isolated from a Japanese hot spring: characterization, gene cloning and sequencing, and expression
Appl. Environ. Microbiol.
70
937-942
2004
Geobacillus stearothermophilus (Q9AJC6), Geobacillus stearothermophilus
Manually annotated by BRENDA team
Ruldeekulthamrong, P.; Maeda, S.; Kato, S.; Shinji, N.; Sittipraneed, S.; Packdibamrung, K.; Misono, H.
Molecular characterization of lysine 6-dehydrogenase from Achromobacter denitrificans
BMB Rep.
41
790-795
2008
Achromobacter denitrificans (Q3S559), Achromobacter denitrificans
Manually annotated by BRENDA team
Yoneda, K.; Fukuda, J.; Sakuraba, H.; Ohshima, T.
First crystal structure of L-lysine 6-dehydrogenase as an NAD-dependent amine dehydrogenase
J. Biol. Chem.
285
8444-8453
2010
Pyrococcus horikoshii (O59312), Pyrococcus horikoshii, Pyrococcus horikoshii ATCC 700860 (O59312)
Manually annotated by BRENDA team
Perez-Garcia, F.; Peters-Wendisch, P.; Wendisch, V.F.
Engineering Corynebacterium glutamicum for fast production of L-lysine and L-pipecolic acid
Appl. Microbiol. Biotechnol.
100
8075-8090
2016
Ruegeria pomeroyi
Manually annotated by BRENDA team
Perez-Garcia, F.; Max Risse, J.; Friehs, K.; Wendisch, V.F.
Fermentative production of L-pipecolic acid from glucose and alternative carbon sources
Biotechnol. J.
12
7-7
2017
Ruegeria pomeroyi (Q5LX24), Ruegeria pomeroyi
Manually annotated by BRENDA team
Tseliou, V.; Knaus, T.; Masman, M.F.; Corrado, M.L.; Mutti, F.G.
Generation of amine dehydrogenases with increased catalytic performance and substrate scope from epsilon-deaminating L-Lysine dehydrogenase
Nat. Commun.
10
3717
2019
Geobacillus stearothermophilus (Q9AJC6)
Manually annotated by BRENDA team