1.4.1.14: glutamate synthase (NADH)
This is an abbreviated version!
For detailed information about glutamate synthase (NADH), go to the full flat file.
Word Map on EC 1.4.1.14
Reaction
2 L-glutamate
+
Synonyms
gltA, GltA2, gltB, glutamate (reduced nicotinamide adenine dinucleotide) synthase, glutamate synthase, glutamate synthase (NADH), glutamate synthase (NADH-dependent), glutamate synthetase, glutamine 2-oxoglutarate aminotransferase, GOGAT, GOGAT1, GOGAT2, L-glutamate synthase (NADH), L-glutamate synthetase, NADH glutamate synthase, NADH-dependent glutamate synthase, NADH-dependent glutamine-2-oxoglutarate aminotransferase, NADH-GltS, NADH-glutamate synthase, NADH-GOGAT, NADH-GOGAT I, NADH-GOGAT II, NADH-GOGAT1, NADH-GOGAT2, NADH: GOGAT, Os01g0681900, Os05g0555600, synthase, glutamate (reduced nicotinamide adenine dinucleotide)
ECTree
1.4.1.14 glutamate synthase (NADH)Advanced search results
results (
results (Inhibitors
Inhibitors on EC 1.4.1.14 - glutamate synthase (NADH)
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(2,5-dioxoimidazolidin-4-yl)urea
-
activity of NADH-GOGAT I significantly decreases in the presence of 10 mM allantoine
2-hydroxyglutarate
-
D- and L-isomer, most potent competitive inhibitor
3-acetylpyridine adenine dinucleotide
-
competitive inhibitor with respect to NADH
allopurinol
-
activity of NADH-GOGAT I significantly decreases in the presence of 2 mM allopurinol
glutamine
-
activity of NADH-GOGAT I significantly decreases in the presence of 10 mM glutamine
L-2-Amino-4-oxo-5-chloropentanoate
-
1 mM, 30 min, 0°C, pH 7.6, irreversible inhibition
L-homocysteine sulfonamide
-
very potent transition state inhibitor, competitive to L-glutamine
O-diazoacetyl-L-serine
-
1 mM, 30 min, 0°C, pH 7.6, irreversible inhibition
oxaloacetate
-
weak inhibition, competitive with 2-oxoglutarate
p-hydroxymercuribenzoate
-
complete inhibition at 0.1-1 mM, at 0.0005 mM 33% inhibition or 75% inhibition after preincubation in presence of glutamine and 2-oxoglutarate, substrates induce a conformation, which makes essential sulfhydryl groups more accessible to reagent
phenylalanine
-
20 mM, complete inhibition
xanthine
-
activity of NADH-GOGAT I significantly decreases in the presence of 10 mM xanthine
(2S)-2-amino-4-(S-methylsulfonimidoyl)butanoic acid
-
potent irreversible inhibitor
6-diazo-5-oxo-L-norleucine
-
0.1 mM, 30 min, 0°C, pH 7.6, irreversible inhibition
asparagine
-
activity of NADH-GOGAT I significantly decreases in the presence of 10 mM asparagine
glycine
-
48% inhibition at 10 mM, complete inhibition at 20 mM
L-Albizziin
-
less inhibitory than L-homocysteine sulfonamide, methionine sulfone and ethionine sulfone
L-glutamate
-
competitive with 2-oxoglutarate; glutamate binds 1.7times more tightly in the presence of NAD+
tryptophan
-
29% inhibition at 10 mM, complete inhibition at 20 mM
additional information
-
not inhibited by 1 mM cyanide or cyanate
-
additional information
-
not inhibited by alanine, glycine, serine, lysine, proline, cysteine, valine, leucine, isoleucine, threonine, phenylalanine, histidine, tryptophan, asparagine, arginine, UTP, ITP, GTP
-
additional information
-
not inhibited by 2,2-dipyridyl or N-ethylmaleimide
-
additional information
-
the presence of asparagine, glutamine, xanthine, allantoin, allopurinol in the nutrient solution does not affect the expression of NADH-GOGAT-II in the nodules
-
additional information
-
cumulative inhibition by combinations of amino acids and nucleotides, cumulative feedback inhibition
-
additional information
-
not inhibited by the 20 common amino acids at a concentration of 20 mM
-
additional information
-
enzyme activity declines significantly between 42-68% and 9-42% relative water content in leaves
-
