1.3.99.5: 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
This is an abbreviated version!
For detailed information about 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor), go to the full flat file.
Word Map on EC 1.3.99.5
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1.3.99.5
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androgen
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prostate
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dihydrotestosterone
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finasteride
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hyperplasia
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progesterone
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aromatase
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steroidogenic
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castrated
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dutasteride
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neurosteroids
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genitalia
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alopecia
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5alpha-dihydrotestosterone
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androstenedione
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antiandrogenic
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17beta-hydroxysteroid
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hypospadias
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gabaa
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allopregnanolone
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17beta-hsd
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masculinization
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androgenetic
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tamsulosin
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virilization
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androgen-dependent
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cyp17a1
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3alpha-hydroxysteroid
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hsd17b3
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neuroactive
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pseudohermaphroditism
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alpha-blocker
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prostate-specific
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libido
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bald
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alpha1-adrenoceptors
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bothersome
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intraprostatic
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micropenis
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terazosin
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doxazosin
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androstanediols
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gonadectomized
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urologist
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3alpha
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hirsutism
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3alpha-hsd
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androsterone
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medicine
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hsd3b1
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akr1c3
- 1.3.99.5
- androgen
- prostate
- dihydrotestosterone
- finasteride
- hyperplasia
- progesterone
- aromatase
-
steroidogenic
-
castrated
- dutasteride
-
neurosteroids
- genitalia
- alopecia
- 5alpha-dihydrotestosterone
- androstenedione
-
antiandrogenic
-
17beta-hydroxysteroid
- hypospadias
-
gabaa
- allopregnanolone
- 17beta-hsd
-
masculinization
-
androgenetic
-
tamsulosin
-
virilization
-
androgen-dependent
- cyp17a1
-
3alpha-hydroxysteroid
- hsd17b3
-
neuroactive
- pseudohermaphroditism
-
alpha-blocker
-
prostate-specific
- libido
-
bald
-
alpha1-adrenoceptors
-
bothersome
-
intraprostatic
-
micropenis
-
terazosin
-
doxazosin
- androstanediols
-
gonadectomized
-
urologist
-
3alpha
- hirsutism
- 3alpha-hsd
- androsterone
- medicine
- hsd3b1
- akr1c3
Reaction
Synonyms
3-keto-DELTA4-steroid-5 alpha-reductase, 3-ketosteroid-DELTA4(5alpha)-dehydrogenase, 3-oxo-5alpha-steroid DELTA4-dehydrogenase, 3-oxo-steroid-4-ene dehydrogenase, 3-oxosteroid DELTA4-dehydrogenase, 4-ene-3-ketosteroid-5alpha-oxidoreductase, 5 alpha-SR2, 5-alpha reductase II, 5alpha reductase, 5alpha-R, 5alpha-R1, 5alpha-reductase, 5alpha-reductase II, 5alpha-reductase type 1, 5alpha-reductase type 2, 5alpha-reductase type II, 5alpha-reductase type1, 5alpha-reductase type2, 5alphaR1, 5alphaR2, 5AR2, dehydrogenase, 3-oxo-5alphasteroid DELTA4-, DELTA4(5alpha)DH, DELTA4-3-keto steroid 5alpha-reductase, DELTA4-3-ketosteroid 5alpha-oxidoreductase, DELTA4-3-oxo steroid reductase, DELTA4-3-oxosteroid-5alpha-reductase, DELTA4-5alpha-dehydrogenase, NADPH-dependent 5alpha-reductase enzyme, r5alphaR1, S5alphaRI, S5alphaRII, S5AR, SRD5A1, SRD5A2, SRD5alpha, steroid 5-alpha reductase type 2, steroid 5-alpha-reductase type 2, steroid 5alpha-reductase, steroid 5alpha-reductase type 1, steroid 5alpha-reductase type 2, steroid DELTA4-5alpha-reductase, steroid-5alpha-reductase, testosterone 5alpha-reductase, type 1 5alpha-reductase, type 2 5alpha-reductase, type I 5alpha-reductase, type II 5alpha-reductase
ECTree
1.3.99.5 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)Advanced search results
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results (Substrates Products
Substrates Products on EC 1.3.99.5 - 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(5alpha)-androst-1-en-3,17-dione + oxidized dichlorophenolindophenol
1,4-androstadiene-3,17-dione + reduced dichlorophenolindophenol
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-
-
?
1-androstene-3,17-dione + acceptor
1,4-androstadiene-3,17-dione + reduced reduced acceptor
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-
-
-
?
1-androstene-3,17-dione + phenazine methosulfate
1,4-androstadiene-3,17-dione + reduced phenazine methosulfate
1-estrene-3,17-dione + phenazine methosulfate
1,4-estradiene-3,17-dione + reduced phenazine methosulfate
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-
-
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ir
5alpha-1-androsten-3,17-dione + acceptor
? + reduced acceptor
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acceptor: N,N,N,N-tetramethyl-1,4-phenylenediamine, menadione, phenazine methosulfate, cytochrome c
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-
ir
5alpha-androstane-3,17-dione + N,N,N',N'-tetramethyl-1,4-phenylendiamine
androst-4-ene-3,17-dione + reduced N,N,N',N'-tetramethyl-1,4-phenylendiamine
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-
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r
deoxycorticosterone + reduced acceptor
21-hydroxy-5alpha-pregnan-3,20-dione + acceptor
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-
-
-
?
1-androstene-3,17-dione + phenazine methosulfate
1,4-androstadiene-3,17-dione + reduced phenazine methosulfate
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-
-
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ir
1-androstene-3,17-dione + phenazine methosulfate
1,4-androstadiene-3,17-dione + reduced phenazine methosulfate
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acceptor: N,N,N,N-tetramethyl-1,4-phenylenediamine, menadione, phenazine methosulfate, cytochrome c
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-
ir
5alpha-dihydrotestosterone + NADP+
testosterone + NADPH + H+
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5alpha-reductase converts testosterone to 5alpha-dihydrotestosterone
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-
r
5alpha-dihydrotestosterone + NADP+
testosterone + NADPH + H+
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-
-
r
5alpha-dihydrotestosterone + NADP+
testosterone + NADPH + H+
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the enzyme performs conversion of testosterone to 5alpha-dihydrotestosterone
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-
r
5alpha-dihydrotestosterone + NADP+
testosterone + NADPH + H+
the enzyme performs conversion of testosterone to 5alpha-dihydrotestosterone
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r
5alpha-pregn-3,20-dione + NADP+
progesterone + NADPH + H+
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5alpha-reductase also can act on progesterone, which is metabolized to an intermediate product that is then converted to allopregnanolone
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r
dihydrotestosterone + NADP+
testosterone + NADPH + H+
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the enzyme performs conversion of testosterone to dihydrotestosterone
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r
dihydrotestosterone + NADP+
testosterone + NADPH + H+
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-
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r
dihydrotestosterone + NADP+
testosterone + NADPH + H+
the isoenzyme efficiently catalyzes the in vitro transformation of testosterone into dihydrotestosterone
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r
dihydrotestosterone + NADP+
testosterone + NADPH + H+
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the enzyme performs conversion of testosterone to dihydrotestosterone
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-
r
testosterone + NADPH + H+
5alpha-dihydrotestosterone + NADP+
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-
-
-
?
testosterone + NADPH + H+
5alpha-dihydrotestosterone + NADP+
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-
-
-
?
testosterone + reduced acceptor
5alpha-dihydrotestosterone + acceptor
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key enzyme in the degradation of steroids having an A:B ring fusion in a trans configuration
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-
?
testosterone + reduced acceptor
5alpha-dihydrotestosterone + acceptor
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-
-
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?
testosterone + reduced acceptor
5alpha-dihydrotestosterone + acceptor
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-
-
-
?
testosterone + reduced acceptor
5alpha-dihydrotestosterone + acceptor
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-
5alpha-dihydrotestosterone is a more potent androgen
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?
testosterone + reduced acceptor
5alpha-dihydrotestosterone + acceptor
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testosterone i.e. 17beta-hydroxyandrost-4-en-3-one
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-
?
testosterone + reduced acceptor
5alpha-dihydrotestosterone + acceptor
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enzyme plays a key role in androgen-dependent target tissues, where it catalyzes the conversion of testosterone to the biologically active dihydrotestosterone, transcriptional control of 5alpha-reductase expression
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-
?
additional information
?
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neonatal testicular androgens, e.g. testosterone, irreversibly program several hepatic enzyme activities in the rat including 5alpha-reductase, tissue-specific physiological regulation of isozymes
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?
additional information
?
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-
the enzyme produces precursors for the biosynthesis of allopregnenolone and tetrahydrodeoxycorticosterone, physiological role of the isozymes in the brain, overview
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?
