1.3.99.5: 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

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For detailed information about 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor), go to the full flat file.

Word Map on EC 1.3.99.5

1.3.99.5

androgen

prostate

dihydrotestosterone

finasteride

hyperplasia

progesterone

aromatase

steroidogenic

castrated

dutasteride

neurosteroids

genitalia

alopecia

5alpha-dihydrotestosterone

androstenedione

antiandrogenic

17beta-hydroxysteroid

hypospadias

gabaa

allopregnanolone

17beta-hsd

masculinization

androgenetic

tamsulosin

virilization

androgen-dependent

cyp17a1

3alpha-hydroxysteroid

hsd17b3

neuroactive

pseudohermaphroditism

alpha-blocker

prostate-specific

libido

bald

alpha1-adrenoceptors

bothersome

intraprostatic

micropenis

terazosin

doxazosin

androstanediols

gonadectomized

urologist

3alpha

hirsutism

3alpha-hsd

androsterone

medicine

hsd3b1

akr1c3

Reaction

Synonyms

3-keto-DELTA4-steroid-5 alpha-reductase, 3-ketosteroid-DELTA4(5alpha)-dehydrogenase, 3-oxo-5alpha-steroid DELTA4-dehydrogenase, 3-oxo-steroid-4-ene dehydrogenase, 3-oxosteroid DELTA4-dehydrogenase, 4-ene-3-ketosteroid-5alpha-oxidoreductase, 5 alpha-SR2, 5-alpha reductase II, 5alpha reductase, 5alpha-R, 5alpha-R1, 5alpha-reductase, 5alpha-reductase II, 5alpha-reductase type 1, 5alpha-reductase type 2, 5alpha-reductase type II, 5alpha-reductase type1, 5alpha-reductase type2, 5alphaR1, 5alphaR2, 5AR2, dehydrogenase, 3-oxo-5alphasteroid DELTA4-, DELTA4(5alpha)DH, DELTA4-3-keto steroid 5alpha-reductase, DELTA4-3-ketosteroid 5alpha-oxidoreductase, DELTA4-3-oxo steroid reductase, DELTA4-3-oxosteroid-5alpha-reductase, DELTA4-5alpha-dehydrogenase, NADPH-dependent 5alpha-reductase enzyme, r5alphaR1, S5alphaRI, S5alphaRII, S5AR, SRD5A1, SRD5A2, SRD5alpha, steroid 5-alpha reductase type 2, steroid 5-alpha-reductase type 2, steroid 5alpha-reductase, steroid 5alpha-reductase type 1, steroid 5alpha-reductase type 2, steroid DELTA4-5alpha-reductase, steroid-5alpha-reductase, testosterone 5alpha-reductase, type 1 5alpha-reductase, type 2 5alpha-reductase, type I 5alpha-reductase, type II 5alpha-reductase

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.99 With unknown physiological acceptors

1.3.99.5 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

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5	Activating Compound
210	AA Sequence
7	Application
1	CAS Registry Number
16	Cloned(Commentary)
7	Cofactor
1	Crystallization (Commentary)
2406	Disease/ Diagnostics
2	Expression
17	General Information
392	IC50 Value
561	Inhibitors
3	kcat/KM [mM/s]
27	Ki Value [mM]
9	KM Value [mM]
6	Localization
2	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
54	Organism
4	Pathway
2	PDB ID
11	pH Optimum
1	pH Range
23	Protein Variants
1	Reaction
3	Reaction Type
54	Reference
66	Source Tissue
2	Specific Activity [micromol/min/mg]
45	Substrates and Products (Substrate)
2	Subunits
84	Synonyms
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1	Temperature Range [°C]
3	Turnover Number [1/s]

KI Value

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KI Value on EC 1.3.99.5 - 3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)

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0.01

(10bR)-8-chloro-4,10b-dimethyl-1,5,6,10b-tetrahydrophenanthridin-3(2H)-one