Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.3.99.4: 3-oxosteroid 1-dehydrogenase

This is an abbreviated version!
For detailed information about 3-oxosteroid 1-dehydrogenase, go to the full flat file.

Word Map on EC 1.3.99.4

Reaction

a 3-oxosteroid
+
acceptor
=
a 3-oxo-DELTA1-steroid
+
reduced acceptor

Synonyms

1-ene-dehydrogenase, 3-keto-5alpha-steroid DELTA(1)-dehydrogenase, 3-ketosteroid 1(2)-dehydrogenase, 3-ketosteroid delta1-dehydrogenase, 3-ketosteroid-1-en-dehydrogenase, 3-ketosteroid-D1-dehydrogenase, 3-ketosteroid-DELTA1-dehydrogenase, 3-ketosteroid-DELTA1-dehydrogenases, 3-oxosteroid D1-dehydrogenase, 3-oxosteroid Delta1-dehydrogenase, 3-oxosteroid:(2,6-dichlorphenolindophenol) DELTA1-oxidoreductase, 3-oxosteroid:(2,6-dichlorphenolindophenol)D1-oxidoreductase, 4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase, 4-ene-3-oxosteroid: (acceptor)-1-ene-oxoreductase, 4-ene-3-oxosteroid:(acceptor)l-ene-oxidoreductase, AcmB, AcmB2, cholest-4-en-3-one DELTA1-dehydrogenase, D1-dehydrogenase, D1-steroid reductase, dehydrogenase, 3-oxo steroid Delta 1-, Delta1-dehydrogenase, DELTA1-KstD, DELTA1-KSTD1, DELTA1-KstDA, DELTA1-KstDR, DELTA1-steroid reductase, ketosteroid DELTA1-dehydrogenase, KsdD, KsdD1, KsdD2, KsdD3, KsdD5, KsdDM, KSDH, KstD, KSTD1, KSTD2, KSTD3, KSTD3 orthologue, KstDF, MnKstD1, MnKstD2, MsKstD1, MsKstD2, MsKstD3, MsKstD4, ReKstD1, Rv3537, steroid-1-dehydrogenase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.99 With unknown physiological acceptors
                1.3.99.4 3-oxosteroid 1-dehydrogenase

Substrates Products

Substrates Products on EC 1.3.99.4 - 3-oxosteroid 1-dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(5alpha,17beta)-17-hydroxyandrostan-3-one + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
, 4,9(11)-androstadiene-3,17-dione + acceptor
? + reduced acceptor
show the reaction diagram
11-deoxy-17alpha-hydroxycorticosterone + acceptor
17,21-dihydroxypregna-1,4-diene-3,20-dione + reduced acceptor
show the reaction diagram
-
4-pregnene-17alpha,21-diol-3,20-dione
-
-
?
11-deoxycorticosterone + acceptor
21-hydroxypregna-1,4-diene-3,20-dione + reduced acceptor
show the reaction diagram
-
-
-
?
11alpha-hydroxy-testosterone + acceptor
11alpha,17beta-dihydroxyandrost-1,4-diene-3-one + reduced acceptor
show the reaction diagram
-
-
-
-
?
11alpha-hydroxyprogesterone + acceptor
11alpha-hydroxy-1,4-pregnene-3,20-dione + reduced acceptor
show the reaction diagram
-
4-pregnene-11alpha-ol-3,20-dione
-
-
?
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + 2,6-dichlorphenolindophenol
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced 2,6-dichlorphenolindophenol
show the reaction diagram
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + acceptor
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced acceptor
show the reaction diagram
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione + phenazine methosulfate
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced phenazine methosulfate
show the reaction diagram
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione acetate + acceptor
1,4-pregnene-17alpha,21-diol-3,11,20-trione acetate + reduced acceptor
show the reaction diagram
11beta-cortisol + 2,6-dichlorophenol-indophenol
(11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
11beta-hydroxy-4-androstene-3,17-dione + acceptor
11beta-hydroxy-1,4-androstene-3,17-dione + reduced acceptor
show the reaction diagram
11beta-hydroxytestosterone + acceptor
11beta,17beta-dihydroxyandrost-1,4-diene-3-one + reduced acceptor
show the reaction diagram
-
4-androstene-11beta,17beta-diol-3-one
-
-
?
16,17alpha-epoxyprogesterone + acceptor
? + reduced acceptor
show the reaction diagram
-
-
-
?
16alpha,17alpha-epoxyprogesterone + acceptor
? + reduced acceptor
show the reaction diagram
17-methyl-testosterone + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
-
-
-
-
?
17alpha,21-dihydroxyprogesterone 21-acetate + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
-
Reichstein substance S 21-acetate (RSA), best substrate
-
-
?
17alpha,21-dihydroxyprogesterone 21-acetate + acceptor
? + reduced acceptor
show the reaction diagram
RSA
-
-
?
17alpha-hydroxy-progesterone + acceptor
1,4-pregnene-17alpha-ol-3,20-dione + reduced acceptor
show the reaction diagram
-
4-pregnene-17alpha-ol-3,20-dione
-
-
?
17alpha-hydroxypregn-4-ene-3,20-dione + acceptor
1,4-pregnene-17alpha-ol-3,20-dione + reduced acceptor
show the reaction diagram
-
-
-
?
17alpha-hydroxypregn-4-ene-3,20-dione + acceptor
? + reduced acceptor
show the reaction diagram
17alpha-hydroxyprogesterone + 2,6-dichlorophenol-indophenol
17alpha-hydroxy-pregna-1,4-diene-3,20-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
-
-
-
-
?
17alpha-hydroxyprogesterone + acceptor
17alpha-hydroxy-pregna-1,4-diene-3,20-dione + reduced acceptor
show the reaction diagram
-
-
-
?
17alpha-methyltestosterone + acceptor
17alpha-methylandrost-1,4-diene-3-one + reduced acceptor
show the reaction diagram
-
-
-
-
?
19-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
19-hydroxy-androst-1,4-diene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
19-nor-4-androstene-3,17-dione + acceptor
19-nor-1,4-androstene-3,17-dione + reduced acceptor
show the reaction diagram
-
4-estren-3,17-dione
-
-
?
19-nortestosterone + acceptor
17beta-hydroxy-1,4-estrene-3-one + reduced acceptor
show the reaction diagram
-
4-estren-17beta-ol-3-one
-
-
?
21-acetoxy-pregna-4,9(11),16-triene-3,20-dinone + acceptor
? + reduced acceptor
show the reaction diagram
21-chloro-17-hydroxy-pregna-4,9(11)-diene-3,20-dione + acceptor
? + reduced acceptor
show the reaction diagram
22-hydroxy-23, 24-bisnorchola-4-en-3-one + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
23,24-bis-nor-5alpha-cholestan-3-one acid + 2,6-dichlorophenol-indophenol
?
show the reaction diagram
25-hydroxycholest-4-en-3-one + acceptor
? + reduced acceptor
show the reaction diagram
-
-
-
?
3-oxo-5beta-cholan-24-oic acid + acceptor
? + reduced acceptor
show the reaction diagram
-
-
-
-
?
3-oxosteroid + acceptor
3-oxo-DELTA1-steroid + reduced acceptor
show the reaction diagram
-
key catalyst in microbial steroid metabolism
-
-
?
4-androsten-3-one-5-ene-17-carboxylic acid + acceptor
? + reduced acceptor
show the reaction diagram
4-androstene-17beta-ol-3-one + 2,6-dichlorophenol-indophenol
1,4-androstadiene-17beta-ol-3-one + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
4-androstene-3,11,17-trione + acceptor
1,4-androstene-3,11,17-trione + reduced acceptor
show the reaction diagram
-
-
-
-
?
4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
1,4-androstadiene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
1,4-androstene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
4-androstene-3,17-dione + acceptor
1,4-androstadiene-3,17-dione + reduced acceptor
show the reaction diagram
4-androstene-3,17-dione + acceptor
1,4-androstene-3,17-dione + reduced acceptor
show the reaction diagram
4-androstene-3,17-dione + FAD
1,4-androstadiene-3,17-dione + FADH2
show the reaction diagram
4-androstene-3,17-dione + phenazine methosulfate
1,4-androstadiene-3,17-dione + reduced phenazine methosulfate
show the reaction diagram
-
-
-
-
r
4-androstene-3,17-dione + phenazine methosulfate
1,4-androstene-3,17-dione + reduced phenazine methosulfate
show the reaction diagram
-
-
-
-
?
4-cholesten-3-one + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
-
-
-
-
?
4-cholesten-3-one + 2,6-dichlorophenol-indophenol
? + reduced acceptor
show the reaction diagram
4-cholesten-3-one + acceptor
? + reduced acceptor
show the reaction diagram
-
-
-
?
4-pregnen-3-one-20beta-carboxylic acid + 2,6-dichlorophenol-indophenol
pregna-1,4-dien-3-one-20beta-carboxylic acid + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
4-pregnene-3,20-dione + acceptor
1,4-pregnene-3,20 dione + reduced acceptor
show the reaction diagram
5alpha-androst-1-en-3-one + acceptor
5alpha-androstan-3-one + reduced acceptor
show the reaction diagram
-
-
-
-
?
5alpha-androstan-3-one-17beta-ol + 2,6-dichlorophenol-indophenol
(5alpha,17beta)-17-hydroxyandrost-1-en-3-one + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
5alpha-androstane-17beta-ol-3-one + 2,6-dichlorophenol-indophenol
5alpha-androst-1-ene-17beta-ol-3-one + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
5alpha-androstane-3,17-dione + 2,6-dichlorophenol-indophenol
5beta-androst-1-en-3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
5alpha-pregnane-3,20-dione + 2,6-dichlorophenol-indophenol
5alpha-pregn-1-en-3,20-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
5beta-androstan-3,17-dione + acceptor
5beta-androst-1-en-3,17-dione + reduced acceptor
show the reaction diagram
-
-
-
-
?
6-dehydrotestosterone acetate + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
9,22-dihydroxy-23,24-bisnorchol-4-ene-3-one + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
-
-
-
?
9alpha-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
9alpha-hydroxy-1,4-androstadiene 3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
9alpha-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
9alpha-hydroxy-androst-1,4-diene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
9alpha-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
9alpha-hydroxyandrost-1,4-diene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
9alpha-hydroxy-4-androstene-3,17-dione + acceptor
9alpha-hydroxy-1,4-androstadiene 3,17-dione + reduced acceptor
show the reaction diagram
9alpha-hydroxy-4-androstene-3,17-dione + acceptor
? + reduced acceptor
show the reaction diagram
-
-
-
?
9alpha-hydroxy-4-androstene-3,17-dione + FAD
9alpha-hydroxy-1,4-androstadiene-3,17-dione + FADH2
show the reaction diagram
a 3-oxosteroid + acceptor
a 3-oxo-delta1-steroid + reduced acceptor
show the reaction diagram
androst-4,9(11)-diene-3,17-dione + acceptor
? + reduced acceptor
show the reaction diagram
androst-4-ene-3,17-dione + acceptor
androsta-1,4-diene-3,17-dione + reduced acceptor
show the reaction diagram
androsta-4,9(11)-diene-3,17-dione + acceptor
? + reduced acceptor
show the reaction diagram
NSC 44826
-
-
?
androstanolone + acceptor
? + reduced acceptor
show the reaction diagram
androsterone + acceptor
3-alpha-hydroxy-1-androstene-17-one + reduced acceptor
show the reaction diagram
-
4-androstene-3,11,17-trione
-
-
?
canrenone + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
-
best substrate
-
-
?
canrenone + acceptor
? + reduced acceptor
show the reaction diagram
-
-
-
?
cholesterol + acceptor
?
show the reaction diagram
cortexolone + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
corticosterone + 2,6-dichlorophenol-indophenol
1,4-pregnene-17alpha,21-diol-3,20-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
-
-
-
?
corticosterone + acceptor
1,4-pregnene-17alpha,21-diol-3,20-dione + reduced acceptor
show the reaction diagram
-
4-pregnene-11beta,21-diol-3,20-dione
-
-
?
cortisol + acceptor
prednisolone + reduced acceptor
show the reaction diagram
-
optimal concentration is 0.1 mg/ml, increase of concentration to 1 mg/ml reduces prednisolone yield
-
-
?
cortisone + acceptor
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced acceptor
show the reaction diagram
cortisone + acceptor
? + reduced acceptor
show the reaction diagram
cortisone + acceptor
prednisone + reduced acceptor
show the reaction diagram
-
-
-
?
cortisone acetate + 2,6-dichlorophenol-indophenol
prednisolone acetate + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
-
-
-
-
?
deoxycorticosterone + 2,6-dichlorophenol-indophenol
1,4-pregnadiene-21-ol-3,20-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
-
-
-
?
deoxycorticosterone + 2,6-dichlorophenol-indophenol
1,4-pregnene-21-ol-3,20-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
deoxycorticosterone + acceptor
1,4-pregnene-21-ol-3,20-dione + reduced acceptor
show the reaction diagram
-
4-pregnene-21-ol-3,20-dione
-
-
?
dihydrotestosterone + acceptor
? + reduced acceptor
show the reaction diagram
-
-
-
?
diosgenone + acceptor
? + reduced acceptor
show the reaction diagram
hydrocorticosterone + acceptor
1,4-pregnene-11beta,17alpha,21-triol-3,20-dione + reduced acceptor
show the reaction diagram
-
4-pregnene-11beta,17alpha,21triol-3,20-dione
-
-
?
hydrocortisone 21-hemisuccinate + acceptor
? + reduced acceptor
show the reaction diagram
-
-
-
?
prednisolone + acceptor
? + reduced acceptor
show the reaction diagram
-
-
-
?
pregn-4-ene-3,20-dione + acceptor
pregn-1,4-diene-3,20-dione + reduced acceptor
show the reaction diagram
pregna-4,9(11),16-triene-3,20-dione + acceptor
? + reduced acceptor
show the reaction diagram
-
-
-
?
progesterone + 2,6-dichlorophenol-indophenol
pregna-1,4-diene-3,20-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
progesterone + acceptor
? + reduced acceptor
show the reaction diagram
-
-
-
-
?
progesterone + acceptor
pregna-1,4-diene-3,20-dione + reduced acceptor
show the reaction diagram
spironolactone + acceptor
? + reduced acceptor
show the reaction diagram
-
-
-
?
testololactone + acceptor
D-homo-17alpha-oxoandrosta-1,4-diene-3,17-one + reduced acceptor
show the reaction diagram
-
D-homo-17a-oxoandrost-4-ene-3,17-dione
-
-
?
testosterone + 2,6-dichlorophenol-indophenol
17beta-hydroxyandrost-1,4-diene-3-one + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
testosterone + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
testosterone + acceptor
17beta-hydroxyandrost-1,4-diene-3-one + reduced acceptor
show the reaction diagram
testosterone propionate + 2,6-dichlorophenol-indophenol
17beta-hydroxyandrost-1,4-diene-3-one propionate + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
additional information
?
-