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1.3.99.36: cypemycin cysteine dehydrogenase (decarboxylating)

This is an abbreviated version!
For detailed information about cypemycin cysteine dehydrogenase (decarboxylating), go to the full flat file.

Reaction

cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys
+
acceptor
=
C3.19,S21-cyclocypemycin(1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide
+
CO2
+
H2S
+
reduced acceptor

Synonyms

CYPD, cypemycin decarboxylase, cypemycin dehydratase.

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.99 With unknown physiological acceptors
                1.3.99.36 cypemycin cysteine dehydrogenase (decarboxylating)

Reference

Reference on EC 1.3.99.36 - cypemycin cysteine dehydrogenase (decarboxylating)

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Claesen, J.; Bibb, M.
Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides
Proc. Natl. Acad. Sci. USA
107
16297-16302
2010
Streptomyces sp., Streptomyces sp. OH-4156
Manually annotated by BRENDA team
Mo, T.; Yuan, H.; Wang, F.; Ma, S.; Wang, J.; Li, T.; Liu, G.; Yu, S.; Tan, X.; Ding, W.; Zhang, Q.
Convergent evolution of the Cys decarboxylases involved in aminovinyl-cysteine (AviCys) biosynthesis
FEBS Lett.
593
573-580
2019
Streptomyces coelicolor, Streptomyces coelicolor M1414
Manually annotated by BRENDA team
Liu, L.; Chan, S.; Mo, T.; Ding, W.; Yu, S.; Zhang, Q.; Yuan, S.
Movements of the substrate-binding clamp of cypemycin decarboxylase CypD
J. Chem. Inf. Model.
59
2924-2929
2019
Streptomyces coelicolor, Streptomyces coelicolor M1414
Manually annotated by BRENDA team
Ding, W.; Yuan, N.; Mandalapu, D.; Mo, T.; Dong, S.; Zhang, Q.
Cypemycin decarboxylase CypD is not responsible for aminovinyl-cysteine (AviCys) ring formation
Org. Lett.
20
7670-7673
2018
Streptomyces coelicolor, Streptomyces coelicolor M1414
Manually annotated by BRENDA team
Ding, W.; Mo, T.; Mandalapu, D.; Zhang, Q.
Substrate specificity of the cypemycin decarboxylase CypD
Synth. Syst. Biotechnol.
3
159-162
2018
Streptomyces coelicolor, Streptomyces coelicolor M1414
Manually annotated by BRENDA team