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1.3.99.27: 1-hydroxycarotenoid 3,4-desaturase

This is an abbreviated version!
For detailed information about 1-hydroxycarotenoid 3,4-desaturase, go to the full flat file.

Reaction

1-hydroxy-1,2-dihydrolycopene
+
acceptor
=
1-hydroxy-3,4-didehydro-1,2-dihydrolycopene
+
reduced acceptor

Synonyms

1-HO carotenoid 3,4-dehydrogenase, 1-hydroxy monocyclic carotenoid 3,4-dehydrogenase, acyclic carotenoid 3,4-desaturase, CrtD, DDD_2394, hydroxyneurosporene desaturase, P99-3 CrtD

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.99 With unknown physiological acceptors
                1.3.99.27 1-hydroxycarotenoid 3,4-desaturase

Crystallization

Crystallization on EC 1.3.99.27 - 1-hydroxycarotenoid 3,4-desaturase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
to 1.97 A resolution. CrtD structure is composed of an FAD-binding domain and a substrate-binding domain, which can be divided into two subdomains, a Rossmann fold-like subdomain and a lid subdomain. The substrate-binding domain constitutes a long and hydrophobic tunnel with a length of about 40 A. The tunnel provides an appropriate substrate-binding site for the carotenoid such as 1'-OH-gamma-carotene with a length of about 35 A