1.3.98.3: coproporphyrinogen dehydrogenase

This is an abbreviated version!
For detailed information about coproporphyrinogen dehydrogenase, go to the full flat file.

Reaction

Synonyms

anaerobic coproporphyrinogen III oxidase, At5g63290, AtHEMN1, BtrN, CgoX, Coprogen oxidase, coproporphyrinogen III oxidase, coproporphyrinogen oxidase, coproporphyrinogenase, CPO, EC 1.3.99.22, HemN, HEMN1, HemW, More, oxidase, coproporphyrinogen, oxygen-independent coproporphyrinogen III oxidase, oxygen-independent coproporphyrinogen-III oxidase, oxygen-independent CPO, radical S-adenosyl-L-methionine dehydrogenase, radical SAM enzyme, Sll1876, Sll1917, viperin

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.98 With other, known, physiological acceptors

                1.3.98.3 coproporphyrinogen dehydrogenase

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Results	in table
2	Activating Compound
19389	AA Sequence
2	Application
1	CAS Registry Number
13	Cloned(Commentary)
29	Cofactor
4	Crystallization (Commentary)
427	Disease/ Diagnostics
1	Expression
16	General Information
8	Inhibitors
2	kcat/KM [mM/s]
7	KM Value [mM]
3	Localization
7	Metals/Ions
2	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
26	Organism
7	Pathway
3	pH Optimum
22	Protein Variants
13	Purification (Commentary)
5	Reaction
4	Reaction Type
25	Reference
1	Renatured (Commentary)
8	Source Tissue
33	Substrates and Products (Substrate)
7	Subunits
63	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
5	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.3.98.3 - coproporphyrinogen dehydrogenase

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SYSTEMATIC NAME

IUBMB Comments

coproporphyrinogen-III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)

This enzyme differs from EC 1.3.3.3, coproporphyrinogen oxidase, by using S-adenosyl-L-methionine (AdoMet) instead of oxygen as oxidant. It occurs mainly in bacteria, whereas eukaryotes use the oxygen-dependent oxidase. The reaction starts by using an electron from the reduced form of the enzyme's [4Fe-4S] cluster to split AdoMet into methionine and the radical 5'-deoxyadenosin-5'-yl. This radical initiates attack on the 2-carboxyethyl groups, leading to their conversion into vinyl groups. This conversion, ---(.)CH-CH2-COO- -> ---CH=CH2 + CO2 + e- replaces the electron initially used.