1.3.98.3: coproporphyrinogen dehydrogenase
This is an abbreviated version!
For detailed information about coproporphyrinogen dehydrogenase, go to the full flat file.
Word Map on EC 1.3.98.3
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1.3.98.3
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viruses
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interferon-inducible
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s-adenosylmethionine
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interferon-stimulated
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5\'-deoxyadenosyl
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ifn-stimulated
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isg15
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ifn-inducible
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radical-mediated
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polyi:c
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myxovirus
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ifitm3
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5'-deoxyadenosine
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maturase
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hydg
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protoporphyrinogen
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chuat
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siniperca
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medicine
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pharmacology
- 1.3.98.3
- viruses
-
interferon-inducible
- s-adenosylmethionine
-
interferon-stimulated
-
5\'-deoxyadenosyl
-
ifn-stimulated
- isg15
-
ifn-inducible
-
radical-mediated
-
polyi:c
-
myxovirus
-
ifitm3
- 5'-deoxyadenosine
-
maturase
- hydg
- protoporphyrinogen
-
chuat
-
siniperca
- medicine
- pharmacology
Reaction
Synonyms
anaerobic coproporphyrinogen III oxidase, At5g63290, AtHEMN1, BtrN, CgoX, Coprogen oxidase, coproporphyrinogen III oxidase, coproporphyrinogen oxidase, coproporphyrinogenase, CPO, EC 1.3.99.22, HemN, HEMN1, HemW, More, oxidase, coproporphyrinogen, oxygen-independent coproporphyrinogen III oxidase, oxygen-independent coproporphyrinogen-III oxidase, oxygen-independent CPO, radical S-adenosyl-L-methionine dehydrogenase, radical SAM enzyme, Sll1876, Sll1917, viperin
ECTree
1.3.98.3 coproporphyrinogen dehydrogenaseAdvanced search results
results (
results (Engineering
Engineering on EC 1.3.98.3 - coproporphyrinogen dehydrogenase
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PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
E145A
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appears colorless, the [4Fe-4S] cluster content is slightly reduced, no detectable S-adenosylmethionine cleavage, no detectable CPO activity
E145I
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appears colorless, the [4Fe-4S] cluster content is slightly reduced, no detectable S-adenosylmethionine cleavage, no detectable CPO activity
F310A
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is slightly yellow, the [4Fe-4S] cluster content is slightly reduced, cleaves only one S-adenosylmethionine molecule per molecule protein, residual CPO activity
F310L
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is slightly yellow, the [4Fe-4S] cluster content is slightly reduced, cleaves only one S-adenosylmethionine molecule per molecule protein, no detectable CPO activity
G111V/G113V
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double mutation of Gly-111 and Gly-113, which are part of the potential GGGTP S-adenosyl-L-methionine binding motif, completely abolishes enzyme activity, reduced Fe-S cluster formation
I329A
Q311A
Y56A
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appears colorless, the [4Fe-4S] cluster content is slightly reduced, no detectable S-adenosylmethionine cleavage, no detectable CPO activity
Y56F
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mutant with 45% of wild-type activity and reduced Fe-S cluster formation
Y56L
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appears colorless, the [4Fe-4S] cluster content is slightly reduced, no detectable S-adenosylmethionine cleavage, no detectable CPO activity
Y74F
additional information
I329A
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contains the same amount of iron-sulfur cluster as the wild-type HemN, but cleaves only one S-adenosylmethionine molecule per molecule protein, no detectable CPO activity
I329A
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exhibits the same yellow-brown color as wild-type HemN, but the [4Fe-4S] cluster content is slightly reduced and cleaves only one S-adenosylmethionine molecule per molecule protein, no detectable CPO activity
Q311A
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contains the same amount of iron-sulfur cluster as the wild-type HemN, but cleaves only one S-adenosylmethionine molecule per molecule protein, no detectable CPO activity
Q311A
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exhibits the same yellow-brown color as wild-type HemN, but the [4Fe-4S] cluster content is slightly reduced and cleaves only one S-adenosylmethionine molecule per molecule protein, no detectable CPO activity
Y74F
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the apparent binding affinity of the mutant enzyme for the cofactor S-adenosyl-L-methionine is higher than that of the wild type enzyme
Y74F
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the apparent binding affinity of the mutant enzyme for the cofactor S-adenosyl-L-methionine is higher than that of the wild type enzyme
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additional information
enzyme knockout by T-DNA insertions in the HEMN1 gene. A 17fold downregulation of AtHEMN1 transcripts occurs in the mutant. The plastidial CPO gene (LIN2) also shows 3.7fold downregulation. The AtHEMN1 mutation prevents the fusion of polar nuclei in the female gametophyte and affects endosperm proliferation. Phenotype, overview
additional information
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enzyme knockout by T-DNA insertions in the HEMN1 gene. A 17fold downregulation of AtHEMN1 transcripts occurs in the mutant. The plastidial CPO gene (LIN2) also shows 3.7fold downregulation. The AtHEMN1 mutation prevents the fusion of polar nuclei in the female gametophyte and affects endosperm proliferation. Phenotype, overview
additional information
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construction of deletion mutants of the HemN genes, growth of the mutant DELTAsll1876 is significantly slower than that of the wild-type under microoxic conditions, while it grows normally under aerobic conditions. Coproporphyrin III is accumulated at a low but significant level in the DELTAsll1876 mutant grown under micro-oxic conditions. No detectable phenotype in DELTAsll1917 under the conditions, phenotypes, overview
