1.3.98.1: dihydroorotate dehydrogenase (fumarate)
This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (fumarate), go to the full flat file.
Word Map on EC 1.3.98.1
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1.3.98.1
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pyrimidine
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leflunomide
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brequinar
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uridine
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plasmodium
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falciparum
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ubiquinone
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teriflunomide
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dhods
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1.3.3.1
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ump
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dihydro-orotate
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triazolopyrimidine
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atovaquone
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1.3.99.11
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dysostosis
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analysis
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medicine
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acrofacial
- 1.3.98.1
- pyrimidine
- leflunomide
- brequinar
- uridine
- plasmodium
- falciparum
- ubiquinone
- teriflunomide
-
dhods
-
1.3.3.1
- ump
-
dihydro-orotate
- triazolopyrimidine
- atovaquone
-
1.3.99.11
- dysostosis
- analysis
- medicine
-
acrofacial
Reaction
Synonyms
(DHO) dehydrogenase, 4,5-L-dihydroorotate:oxygen oxidoreductase, ACT/DHOD, class 1A DHOD, class 1A DHODH, class 1A dihydroorotate dehydrogenase, DHOD, DHOD1, DHOD2, DHOD3, DHODA, DHOdehase, DHODH, DHODH-1A, dihydroorotate dehydrogenase, dihydroorotate dehydrogenase class 1A, Dihydroorotate oxidase, EC 1.3.3.1, LmDHODH, More, oxidase, dihydroorotate, TcDHOD
ECTree
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Inhibitors
Inhibitors on EC 1.3.98.1 - dihydroorotate dehydrogenase (fumarate)
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1-(1-naphthyl)-3-[2-(trifluoromethyl)phenyl]urea
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50% inhibition at 0.0004 mM, wild type, 0.00034 mM, mutant R265A, above 0.2, mutant H185A
1-(2-methoxyphenyl)-3-(1-naphthyl)urea
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50% inhibition at 0.00023 mM, wild type, 0.00024 mM, mutant R265A, 0.140, mutant H185A
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-(4-methyl-benzylamide) 5-phenylamide
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minimum inhibitory concentration 0.032 mg/ml
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-(isobutyl-amide)
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minimum inhibitory concentration above 0.064 mg/ml
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-[(4-carbamoyl-phenyl)-amide]
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minimum inhibitory concentration 0.008 mg/ml
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-phenylamide 3-[(pyridin-3-ylmethyl)-amide]
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minimum inhibitory concentration 0.00025 mg/ml
1-(4-Chloro-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-[(4-piperidin-1-yl-phenyl)-amide] 3-[(pyridin-3-ylmethyl)-amide]
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minimum inhibitory concentration 0.002 mg/ml
1-(4-chlorophenyl)-3-quinolin-8-ylurea
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50% inhibition at 0.00078 mM, wild type, 0.002 mM, mutant R265A, above 0.4, mutant H185A
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-(isobutyl-amide) 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
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minimum inhibitory concentration 0.064 mg/ml
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzhydryl-amide 5-benzylamide
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minimum inhibitory concentration above 0.032 mg/ml
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 3-benzylamide 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
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minimum inhibitory concentration 0.003 mg/ml
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-benzylamide 3-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide]
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minimum inhibitory concentration above 0.032 mg/ml
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-phenylamide 3-[(pyridin-3-ylmethyl)-amide]
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minimum inhibitory concentration 0.0005 mg/ml
1-(4-Methoxy-phenyl)-1H-pyrazole-3,5-dicarboxylic acid 5-[[4-(pyrrolidine-1-carbonyl)-phenyl]-amide] 3-[(tetrahydro-furan-2-yl)-amide]
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minimum inhibitory concentration above 0.032 mg/ml
2-methyl-3-nitro-N-[3-(trifluoromethyl)phenyl]benzamide
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50% inhibition at 0.00008 mM, wild type, 0.00037 mM, mutant R265A, 0.120, mutant H185A
2-methyl-N-1-naphthyl-3-nitrobenzamide
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50% inhibition at 0.00008 mM, wild type, 0.00048 mM, mutant R265A, 0.180, mutant H185A
5-[(dimethylamino)methyl]-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
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Barbiturate
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dead-end inhibitor, competitive with respect to (S)-dihydroorotate
leflunomide
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cell line A20R resistant to leflunomide shows enhanced expression of enzyme to bypass the inhibitory effect, following long-time exposure, enzyme gene amplification can be assumed
Mercuric chloride
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40% inhibition after 15 min at 0.000045 mM
methanol extract of brown algae Fucus evanescens
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59% inhibition, noncompetitive
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methanol extract of brown algae Pelvetia babingtonii
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58% inhibition, noncompetitive
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N-(2,4-dichlorophenyl)-2-naphthamide
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50% inhibition at 0.00005 mM, wild type, 0.00008 mM, mutant R265A, above 0.05, mutant H185A
N-(2-fluorophenyl)naphthalene-2-carboxamide
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50% inhibition at 0.00047 mM, wild type, 0.00030 mM, mutant R265A, 0.21, mutant H185A
N-(3,4-dichlorophenyl)-2-methyl-3-nitrobenzamide
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50% inhibition at 0.00008 mM, wild type, 0.0028 mM, mutant R265A, 0.06, mutant H185A
N-(3,4-difluorophenyl)-2-methyl-3-nitrobenzamide
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50% inhibition at 0.00026 mM, wild type, 0.00082 mM, mutant R265A, 0.25, mutant H185A
N-(3,5-dichlorophenyl)-2-methyl-3-nitrobenzamide
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50% inhibition at 0.00002 mM, wild type, 0.0004 mM, mutant R265A, 0.13, mutant H185A
N-(3-bromophenyl)-2-methyl-3-nitrobenzamide
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50% inhibition at 0.00006 mM, wild type, 0.0012 mM, mutant R265A, 0.140, mutant H185A
N-(3-chloro-4-fluorophenyl)-2-methyl-3-nitrobenzamide
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50% inhibition at 0.0001 mM, wild type, 0.0005 mM, mutant R265A, 0.13, mutant H185A
N-(4-bromo-2-methylphenyl)-2-naphthamide
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50% inhibition at 0.00005 mM, wild type, 0.00005 mM, mutant R265A, 0.57, mutant H185A
N3-benzyl-1-(4-chlorophenyl)-N5-phenyl-1H-pyrazole-3,5-dicarboxamide
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minimum inhibitory concentration 0.000125 mg/ml
p-hydroxymercuribenzoate
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98% inhibition after 5 min at 0.00227 mM
Tiron
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inhibits cytochrome c reduction and sulfite autoxidation
Orotate
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competitive to dihydroorotate in ferricyanide reduction assay
Orotate
competitively inhibits all three DHOD enzymes to a comparable level
additional information
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markable sensitivity to sulfhydryl inhibitors
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additional information
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visible light is inactivating
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additional information
brequinar and DPC-AE661100 have no effect, even at a concentration of 1 mM
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additional information
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brequinar and DPC-AE661100 have no effect, even at a concentration of 1 mM
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