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1.3.5.2: dihydroorotate dehydrogenase (quinone)

This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (quinone), go to the full flat file.

Word Map on EC 1.3.5.2

Reaction

(S)-dihydroorotate
+
a quinone
=
Orotate
 +
a quinol

Synonyms

class 2 dihydroorotate dehydrogenases, DHO-DH, DHOD, DHODase, DHODH, dihydroorotate dehydrogenase, EC 1.3.99.11, ETH_00004975, hDHODH, HsDHODH, L-5,6-dihydroorotate:ubiquinone exidoreductase, PfDHODH

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.5 With a quinone or related compound as acceptor
                1.3.5.2 dihydroorotate dehydrogenase (quinone)

IC50 Value

IC50 Value on EC 1.3.5.2 - dihydroorotate dehydrogenase (quinone)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000117 - 0.0925
(2Z)-2-cyano-3-cyclopropyl-3-hydroxy-N-[4-(trifluoromethyl)phenyl]prop-2-enamide
-
0.00018 - 0.004
(2Z)-2-cyano-N-(2',3-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide
-
0.000022 - 0.165
(2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide
-
0.00019 - 0.2366
(2Z)-2-cyano-N-(2,3'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide
-
0.00013 - 0.182
(2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide
-
0.00013 - 0.0474
(2Z)-N-(2'-chlorobiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
-
0.0002 - 0.0086
(2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
-
0.00009 - 0.0257
(2Z)-N-(biphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
0.00017 - 0.0062
(2Z)-N-[2'-chloro-3-(trifluoromethyl)biphenyl-4-yl]-2-cyano-3-hydroxybut-2-enamide
-
0.0088 - 0.034
1,4-benzoquinone
0.00385
1-(2-((3,4-dimethylphenyl)amino)-4-methylthiazol-5-yl)-ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00394
1-(2-((3-chloro-4-methylphenyl)amino)-4-methylthiazol-5-yl)ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
1-(2-((3-fluoro-4-methylphenyl)amino)-4-methylthiazol-5-yl)ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00365
1-(2-((4-(tert-butyl)phenyl)amino)-4-methylthiazol-5-yl)-ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00193
1-(2-((4-bromo-3-(trifluoromethyl)phenyl)amino)-4-methylthiazol-5-yl)ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
1-(2-((4-bromophenyl)amino)-4-methylthiazol-5-yl)-ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00235
1-(2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-4-methylthiazol-5-yl)ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
1-(2-(anthracen-2-ylamino)-4-methylthiazol-5-yl)ethan-1-one
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00023 - 0.11
1-(2-methoxyphenyl)-3-naphthalen-1-ylurea
0.000562
1-(4-methyl-2-(naphthalen-2-ylamino)thiazol-5-yl)ethan-1-one
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
1-(4-methyl-2-(phenylamino)thiazol-5-yl)ethanone
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000554 - 1.635
1-hydroxy-2-dodecyl-4(1)quinolone
0.00076
10-phenyl-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.000077
2,8-dimethyl-N-[4-(trifluoromethyl)phenyl]pyrrolo[1,2-a]pyrimidin-4-amine
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.007 - 0.021
2-(1,1-difluoroethyl)-5-methyl-N-[4-(pentafluoro-lambda6-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
-
0.0000118
2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methyl-6-(trifluoromethyl)-1,7-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000127
2-(2'-methoxy-[1,1'-biphenyl]-4-yl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.268
2-(2,3-bis(benzyloxy)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000123 - 0.00019
2-(2,3-dichloroanilino)-3-hydroxynaphthalene-1,4-dione
-
0.34
2-(2,4-bis(benzyloxy)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
2.549
2-(2,4-dimethoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0099 - 0.01
2-(2,6-dimethylanilino)-3-hydroxynaphthalene-1,4-dione
-
0.000078 - 0.000808
2-(2-chloroanilino)-3-hydroxynaphthalene-1,4-dione
-
0.27
2-(3,4-bis(benzyloxy)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.153
2-(3,4-dibutoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
1.073
2-(3,4-dihydroxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.148
2-(3,4-diisobutoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
1.387
2-(3,4-dimethoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.384
2-(3,4-dipropoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000129 - 0.000911
2-(3-chloroanilino)-3-hydroxynaphthalene-1,4-dione
-
0.449
2-(3-methoxy-4-propoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0084
2-(4-(1H-imidazol-1-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000148
2-(4-(2-(trifluoromethyl)pyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00526
2-(4-(2-chloro-6-methylpyridin-3-yl)phenyl)-3-methyl-1,7-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000184
2-(4-(2-chloro-6-methylpyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000262
2-(4-(2-chloro-6-methylpyridin-3-yl)phenyl)-6-fluoro-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000235
2-(4-(2-chloro-6-methylpyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000542
2-(4-(2-chloropyridin-3-yl)phenyl)-3,6-dimethylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000259
2-(4-(2-chloropyridin-3-yl)phenyl)-3-methyl-1,7-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000201
2-(4-(2-chloropyridin-3-yl)phenyl)-3-methyl-6-(trifluoromethyl)-1,7-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000543
2-(4-(2-chloropyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00000971
2-(4-(2-chloropyridin-3-yl)phenyl)-6-fluoro-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000327
2-(4-(2-chloropyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00248
2-(4-(2-fluoro-6-methylpyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000504
2-(4-(2-fluoropyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00142
2-(4-(2-fluoropyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000165
2-(4-(2-methoxypyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000221
2-(4-(2-methylpyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00143
2-(4-(4-(trifluoromethyl)pyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000373
2-(4-(4-methylpyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0125
2-(4-(6-fluoropyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.467
2-(4-(benzyloxy)-3-methoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00807
2-(4-(piperidin-1-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00801 - 0.2
2-(4-(pyridazin-3-yl)phenyl)quinoline-4-carboxylic acid
-
0.0101
2-(4-(pyridin-2-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000391
2-(4-(pyridin-3-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00755
2-(4-(pyridin-4-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.2
2-(4-(pyrimidin-2-yl)phenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.34
2-(4-butoxy-3-methoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000185 - 0.000541
2-(4-chloroanilino)-3-hydroxynaphthalene-1,4-dione
-
0.00025
2-(4-cyclohexylphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00033 - 0.001
2-(4-fluoroanilino)-3-hydroxynaphthalene-1,4-dione
-
0.944
2-(4-hydroxy-3-methoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.438
2-(4-isobutoxy-3-methoxyphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00104
2-(4-isobutylphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00341
2-(4-isopropylphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.144
2-(4-methylphenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.2
2-(4-morpholinophenyl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00279
2-([1,1'-biphenyl]-4-yl)-3-methyl-1,6-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000283
2-([1,1'-biphenyl]-4-yl)-3-methyl-1,7-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00122
2-([1,1'-biphenyl]-4-yl)-3-methyl-1,8-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000212
2-([1,1'-biphenyl]-4-yl)-3-methyl-6-(trifluoromethyl)-1,7-naphthyridine-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000754
2-([1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000051
2-([1,1'-biphenyl]-4-yl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0021 - 0.0026
2-anilino-3-hydroxynaphthalene-1,4-dione
-
0.079
2-chloro-3-(methylamino)naphthalene-1,4-dione
Schistosoma mansoni
pH 8.2, 25°C
-
0.00044 - 0.491
2-cyano-3-(9-ethyl-9H-carbazol-3-ylamino)acrylic acid ethyl ester
0.096
2-cyano-3-hydroxy-N-(2',3,3'-trichlorobiphenyl-4-yl)but-2-enamide
Toxoplasma gondii
-
pH 8.0, 30°C
0.000023 - 0.000709
2-hydroxy-3-(3-methylbutyl)naphthalene-1,4-dione
-
0.0047
2-hydroxy-3-(4-methoxyanilino)naphthalene-1,4-dione
Schistosoma mansoni
pH 8.2, 25°C
-
0.000711 - 0.0068
2-hydroxy-3-(4-phenylpiperazin-1-yl)naphthalene-1,4-dione
-
0.000108 - 0.000111
2-hydroxy-3-[3-(trifluoromethyl)anilino]naphthalene-1,4-dione
-
0.00038
2-hydroxy-3-[4-(4-nitrophenyl)piperazin-1-yl]naphthalene-1,4-dione
Schistosoma mansoni
pH 8.2, 25°C
-
0.091
2-hydroxyethylidene-cyano acetic acid 4-trifluoromethyl anilide
Toxoplasma gondii
-
pH 8.0, 30°C
0.057
2-methylcyclohexa-2,5-diene-1,4-dione
Schistosoma mansoni
pH 8.2, 25°C
0.768
2-tert-butylcyclohexa-2,5-diene-1,4-dione
Schistosoma mansoni
pH 8.2, 25°C
-
0.00105 - 0.0021
2-[(2,3-dihydro-1,4-benzodioxin-6-yl)amino]-3-hydroxynaphthalene-1,4-dione
-
0.000013 - 0.1
2-[(2,5-dichlorophenyl)sulfanyl]-5-ethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
0.000051 - 0.011
2-[(2,5-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
0.0036 - 0.0055
2-[(2H-1,3-benzodioxol-5-yl)amino]-3-hydroxynaphthalene-1,4-dione
-
0.0019 - 0.0065
2-[(3,4-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
0.001 - 0.039
2-[(4-chlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol
0.00093 - 0.03
2-[(E)-2-(2-methylphenyl)ethenyl]quinolin-4-ol
0.00044 - 0.0018
2-[4-(2,3-dichlorophenyl)piperazin-1-yl]-3-hydroxynaphthalene-1,4-dione
-
0.00028 - 0.0046
2-[4-(4-chlorophenyl)piperazin-1-yl]-3-hydroxynaphthalene-1,4-dione
-
0.001
2-[[(4-chlorophenyl)methyl]sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one
Plasmodium falciparum
-
pH and temperature not specified in the publication
0.00144
3-(3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazol-9-yl)phenol
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.0079 - 0.0314
3-(3-methylbut-2-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl 4-methylbenzene-1-sulfonate
-
0.00181
4-(3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazol-9-yl)phenol
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00182
4-(6-imino-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-9-yl)benzamide
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00011 - 0.03
4-pentyl-1,3,4,10-tetrahydroacridin-9(2H)-one
0.00016
5,6-dimethyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.00047 - 0.0007
5-(1H-benzimidazol-1-yl)-N-propylthiophene-2-carboxamide
0.00046 - 0.00071
5-(1H-indol-1-yl)-N-propylthiophene-2-carboxamide
0.00017 - 0.00063
5-(2-methyl-1H-benzimidazol-1-yl)-N-propylthiophene-2-carboxamide
0.000042 - 0.03
5-(2-methyl-1H-indol-1-yl)-N-propylthiophene-2-carboxamide
0.01 - 0.03
5-(4-methylpiperazin-1-yl)-N-propylthiophene-2-carboxamide
0.01 - 0.03
5-(piperidin-1-yl)-N-propylthiophene-2-carboxamide
0.00019
5-ethyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.000081
5-methoxy-2-[(4-phenoxyphenyl)amino]benzoic acid
Homo sapiens
pH 8.0, 22°C
0.0017
5-methyl-7-(naphthalen-2-yloxy)[1,2,4]triazolo[1,5-a]pyrimidine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.1
5-methyl-7-(naphthalen-2-ylsulfanyl)[1,2,4]triazolo[1,5-a]pyrimidine
Plasmodium falciparum
above, pH not specified in the publication, temperature not specified in the publication
0.000047 - 0.2
5-methyl-N-(naphthalen-2-yl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
0.00028 - 0.025
5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
0.000015
6-chloro-2-(2'-fluorobiphenyl-4-yl)quinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
0.0000744
6-chloro-2-(4-(2-chloro-6-methylpyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000036
6-chloro-2-(4-(2-chloropyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.000165
6-chloro-2-(4-(2-fluoropyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.00331
6-fluoro-2-(4-(2-fluoro-6-methylpyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.0000794
6-fluoro-2-(4-(2-fluoropyridin-3-yl)phenyl)-3-methylquinoline-4-carboxylic acid
Homo sapiens
pH 8.0, 22°C
-
0.1
6-methyl-N-phenyl-3aH-inden-4-amine
Plasmodium falciparum
above, pH not specified in the publication, temperature not specified in the publication
0.00129
8-(1,3,3a,4-tetrahydro-2-benzofuran-4-yl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.0011
8-(1,8a-dihydronaphthalen-1-yl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00153
8-(oxolan-2-yl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00148
8-(pyridin-3-yl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00094
8-(thiolan-3-yl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.0013
9-(1-benzofuran-2-yl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00097
9-(2,3-dihydro-1,4-benzodioxin-6-yl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00118
9-(2-methoxyphenyl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00115
9-(2-nitrophenyl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00118
9-(2H-1,3-benzodioxol-5-yl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00152
9-(3-ethylphenyl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.0013
9-(4-nitrophenyl)-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00107
9-(4-phenoxyphenyl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00096
9-(isoquinolin-6-yl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00085
9-(naphthalen-1-yl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00065
9-(naphthalen-2-yl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00068
9-phenyl-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00151
9-phenyl-3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazole
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00107
9-[(E)-2-phenylethenyl]-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00156
9-[3-[(propan-2-yl)oxy]phenyl]-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00096
9-[4-(methylsulfanyl)phenyl]-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00143
9-[4-(trifluoromethoxy)phenyl]-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00043 - 0.0027
atovaquone
0.00001 - 0.02
brequinar
0.00016 - 0.03
diethyl [(dibenzo[b,d]thiophen-2-ylamino)methylidene]propanedioate
0.000026
ethyl 2-((2,3-dihydro-1h-inden-5-yl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000174
ethyl 2-((3,4-dichlorophenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.001358
ethyl 2-((3,4-dimethylphenyl)amino)-4-methylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000058
ethyl 2-((3,4-dimethylphenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000393
ethyl 2-((3,5-dichlorophenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000311
ethyl 2-((3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)-amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((3-chloro-4-((2-chloro-6-fluorobenzyl)oxy)phenyl)-amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000372
ethyl 2-((3-chloro-4-methylphenyl)amino)-4-cyclopropylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000969
ethyl 2-((3-chloro-4-methylphenyl)amino)-4-methylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000035
ethyl 2-((3-chloro-4-methylphenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((3-chloro-4-phenoxyphenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.001987
ethyl 2-((3-fluoro-4-methylphenyl)amino)-4-methylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000049
ethyl 2-((3-fluoro-4-methylphenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((3-fluoro-[1,1'-biphenyl]-4-yl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((4-(benzyloxy)-3-chlorophenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000284
ethyl 2-((4-(tert-butyl)phenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-((4-bromo-2-methylphenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000128
ethyl 2-((4-bromo-3-(trifluoromethyl)phenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00907
ethyl 2-((4-bromophenyl)amino)-4-methylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00604
ethyl 2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-4-(cyclopropanecarboxamido)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000131
ethyl 2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000239
ethyl 2-((4-chlorophenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00144
ethyl 2-((4-methoxyphenyl)amino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000453
ethyl 2-(anthracen-2-ylamino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.001108
ethyl 2-(benzo[d][1,3]dioxol-5-ylamino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000029
ethyl 2-(naphthalen-2-ylamino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 2-([1,1'-biphenyl]-4-ylamino)-4-phenylthiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00004 - 0.03
ethyl 4-(4-ethoxybenzyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate
0.01
ethyl 4-(cyclopropanecarboxamido)-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000515
ethyl 4-(tert-butyl)-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000552
ethyl 4-(tert-butyl)-2-((3-chloro-4-methylphenyl)amino)-thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000652
ethyl 4-(tert-butyl)-2-((3-fluoro-4-methylphenyl)amino)-thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00211
ethyl 4-amino-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 4-amino-2-((4-chloro-3-(trifluoromethyl)phenyl)-amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.00903
ethyl 4-benzamido-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.01
ethyl 4-benzamido-2-((4-chloro-3-(trifluoromethyl)phenyl)-amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000325
ethyl 4-cyclopropyl-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000645
ethyl 4-cyclopropyl-2-((4-fluoro-3-methylphenyl)amino)-thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000887
ethyl 4-methyl-2-(naphthalen-2-ylamino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000408
ethyl 4-phenyl-2-((4-(trifluoromethyl)phenyl)amino)-thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000018
ethyl 4-phenyl-2-((5,6,7,8-tetrahydronaphthalen-2-yl)-amino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000784
ethyl 4-phenyl-2-(phenylamino)thiazole-5-carboxylate
Homo sapiens
Q02172
at pH 8.0 and 22°C
0.000014 - 0.000042
Genz-667348
0.000012 - 0.000044
Genz-668857
0.000015 - 0.00005
Genz-669178
0.0012 - 0.01
isolapachol
-
0.000019 - 0.0001
Lapachol
0.029
Lawsone
Schistosoma mansoni
pH 8.2, 25°C
0.0009
leflunomide
Homo sapiens
pH 8.0, 22°C
0.05
methyl 2-(4-(4-(trifluoromethyl)pyridin-3-yl)phenyl)quinoline-4-carboxylate
Homo sapiens
pH 8.0, 22°C
-
0.2
methyl 2-(4-(piperidin-1-yl)phenyl)quinoline-4-carboxylate, methyl 2-(4-(pyridin-3-yl)phenyl)quinoline-4-carboxylate, methyl 2-(4-cyclohexylphenyl)quinoline-4-carboxylate, methyl 2-([1,1'-biphenyl]-4-yl)quinoline-4-carboxylate
Homo sapiens
pH 8.0, 22°C
-
0.00143
methyl 3-(3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazol-9-yl)benzoate
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00115
methyl 4-(3,4-dihydro-2H-pyrimido[1,2-b][1,2]benzothiazol-9-yl)benzoate
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00122
methyl 4-(6-imino-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-9-yl)benzoate
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00005 - 0.05
N-(2,4-dichlorophenyl)naphthalene-2-carboxamide
0.1
N-(2-chlorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
above, pH not specified in the publication, temperature not specified in the publication
0.1
N-(2-fluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
above, pH not specified in the publication, temperature not specified in the publication
0.049 - 12
N-(3,5-dichloro-phenyl)-2-methyl-3-nitro-benzamide
0.000016 - 0.2
N-(3,5-dichlorophenyl)-2-methyl-3-nitrobenzamide
0.06
N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide
Toxoplasma gondii
-
pH 8.0, 30°C
0.00068 - 0.0014
N-(3-chlorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
0.0005 - 0.0092
N-(3-fluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
0.00078
N-(4-bromophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.019
N-(4-fluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.000056 - 0.0007
N-(anthracen-2-yl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
0.003
N-(anthracen-2-yl)-N,5-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
Plasmodium falciparum
pH not specified in the publication, temperature not specified in the publication
0.00021 - 0.0044
N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
0.00025 - 0.00038
N-cyclopropyl-5-(2,3-dihydro-4H-1,4-benzothiazin-4-yl)thiophene-2-carboxamide
0.01 - 0.03
N-propyl-5-(1H-pyrazol-1-yl)thiophene-2-carboxamide
0.000077 - 0.00021
N-[3-fluoro-4-(trifluoromethyl)phenyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
0.000163 - 0.05
teriflunomide
0.00076
trifluoromethyl 6-(6-imino-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-9-yl)-1H-indole-3-carboxylate
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.00121
[4-(6-imino-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-9-yl)phenyl](4-[[(prop-2-yn-1-yl)oxy]methyl]phenyl)methanone
Plasmodium falciparum
pH 8.0, temperature not specified in the publication
-
0.0025
[[3-(3-methylbut-2-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]oxy]acetonitrile
Schistosoma mansoni
pH 8.2, 25°C
-
additional information
A77 1726