1.3.5.2: dihydroorotate dehydrogenase (quinone)
This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (quinone), go to the full flat file.
Word Map on EC 1.3.5.2
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1.3.5.2
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pyrimidine
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falciparum
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plasmodium
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leflunomide
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brequinar
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uridine
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malaria
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arthritis
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antimalarial
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rheumatoid
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dihydroorotase
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salvage
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teriflunomide
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dhods
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autoimmune
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orotidine
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ump
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atovaquone
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triazolopyrimidine
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flavoenzyme
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medicine
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phosphoribosyltransferase
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antirheumatic
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coq
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drug development
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decylubiquinone
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dmards
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synthesis
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species-selective
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pyre
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pharmacology
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isoxazole
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transcarbamoylase
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5-fluoroorotate
- 1.3.5.2
- pyrimidine
- falciparum
- plasmodium
- leflunomide
- brequinar
- uridine
- malaria
- arthritis
-
antimalarial
-
rheumatoid
- dihydroorotase
-
salvage
- teriflunomide
-
dhods
- autoimmune
- orotidine
- ump
- atovaquone
- triazolopyrimidine
-
flavoenzyme
- medicine
-
phosphoribosyltransferase
-
antirheumatic
- coq
- drug development
- decylubiquinone
-
dmards
- synthesis
-
species-selective
-
pyre
- pharmacology
-
isoxazole
-
transcarbamoylase
- 5-fluoroorotate
Reaction
Synonyms
class 2 dihydroorotate dehydrogenases, DHO-DH, DHOD, DHODase, DHODH, dihydroorotate dehydrogenase, EC 1.3.99.11, ETH_00004975, hDHODH, HsDHODH, L-5,6-dihydroorotate:ubiquinone exidoreductase, PfDHODH
ECTree
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Cloned
Cloned on EC 1.3.5.2 - dihydroorotate dehydrogenase (quinone)
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expressed in Escherichia coli DH5alpha TAP330, lacking the endogenous gene for the bacterial dihydroorotate dehydrogenase, pyrimidine auxotroph
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expressed in Escherichia coli XL-1 Blue, histidine tagged
expression in Escherichia coli
expression in Escherichia coli BL21(DE3) TAP330, a pyrD(-) minus derivative
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expression in Escherichia coli pyrD using a construct with His-tag fusion
expression of complete catalytically active enzyme in SF21 insect cells of Spodoptera frugiperda with baculovirus vector system
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expression of the expression construct pET28b-TEVpfDHODDELTA384413 in Escherichia coli strain BL21
full-length DHODH and N-terminally truncated DHODH, which lacks the targeting sequence and the transmembrane domain recombinantly expressed in Escherichia coli BL21
overexpression of Escherichia coli dihyroorotate dehyrogenase in same strain, partially deleted for the chromosomal pyrD gene, clone selection followed by ampicillin and by complementation of the pyrimidine requirement
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expression in Escherichia coli pyrD using a construct with His-tag fusion