1.3.3.3: coproporphyrinogen oxidase
This is an abbreviated version!
For detailed information about coproporphyrinogen oxidase, go to the full flat file.
Word Map on EC 1.3.3.3
-
1.3.3.3
-
heme
-
protoporphyrinogen
-
coproporphyria
-
protoporphyrin
-
porphyria
-
ferrochelatase
-
uroporphyrinogen
-
5-aminolevulinic
-
porphobilinogen
-
tetrapyrrole
-
porphyrinogens
-
medicine
-
oxygen-independent
-
coproporphyrinuria
-
mg-protoporphyrin
-
ala-pdt
-
delta-aminolaevulinic
-
uroporphyrin
-
cutanea
-
analysis
- 1.3.3.3
- heme
- protoporphyrinogen
- coproporphyria
- protoporphyrin
- porphyria
-
ferrochelatase
- uroporphyrinogen
-
5-aminolevulinic
- porphobilinogen
- tetrapyrrole
-
porphyrinogens
- medicine
-
oxygen-independent
-
coproporphyrinuria
- mg-protoporphyrin
-
ala-pdt
-
delta-aminolaevulinic
-
uroporphyrin
-
cutanea
- analysis
Reaction
Synonyms
copro'gen oxidase, Coprogen oxidase, coproporphyinogen oxidase, coproporphyrinogen III oxidase, coproporphyrinogen oxidase, coproporphyrinogen-III oxidase, coproporphyrinogenase, COX, CPgen oxidase, CPGox, CPO, CPO III oxidase, CPOX, CPOX4, CPX, CPX1, CPX2, HEM13, Hem13p, HemF, HEMN1, KlHEM13, LIN2, LMM2, O2-dependent coproporphyrinogen III oxidase, oxygen-dependent coproporphyrinogen III oxidase, oxygen-dependent coproporphyrinogen-III oxidase, Sll1185
ECTree
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Substrates Products
Substrates Products on EC 1.3.3.3 - coproporphyrinogen oxidase
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REACTION DIAGRAM
17-(3-carboxypropyl)-5,10,15,20,22,24-hexahydro-3,7,13,18-tetramethyl-21H,23H-porphine-2,8,12-tripropanoic acid + O2
? + CO2
-
generates a vinyl group on ring-A
-
?
17-ethylharderoporphyrinogen-III + O2 + 2 H+
17-ethylprotoporphyrinogen-IX + 2 CO2 + 2 H2O
2,4-bis-(beta-hydroxypropionic acid) deuteroporphyrinogen IX + O2
protoporphyrinogen IX + CO2
-
one sixth of the rate compared to coproporhyrinogen-III
-
?
2-beta-hydroxypropionic acid-4-propionic acid deuteroporphyrinogen IX + O2
protoporphyrinogen IX + CO2
-
80% of the activity compared to coproporphyrinogen-III
-
?
2-propionic acid-4-beta-hydroxypropionic acid deuteroporphyrinogen IX + O2
protoporphyrinogen IX + CO2
-
8% of the activity compared to coproporphyrinogen-III
-
?
3-[7,13-di(2-carboxy-ethyl)-17-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13-(2-carboxy-ethyl)-17-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
-
?
3-[7,13-di(2-carboxy-ethyl)-17-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13-(2-carboxy-ethyl)-17-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + 3-[7,13-divinyl-17-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
-
-
?
3-[7,17-di(2-carboxy-ethyl)-13-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-17-(2-carboxy-ethyl)-13-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
-
?
3-[7,17-di(2-carboxy-ethyl)-13-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-17-(2-carboxy-ethyl)-13-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
-
-
?
3-[7-(2-carboxy-ethyl)-13,17-di-tert-butyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-di-tert-butyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
-
?
3-[7-(2-carboxy-ethyl)-13,17-dibutyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-dibutyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
-
-
?
3-[7-(2-carboxy-ethyl)-13,17-diethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-diethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
3-[7-(2-carboxy-ethyl)-13,17-diisopropyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-diisopropyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
-
?
3-[7-(2-carboxy-ethyl)-13,17-dipropyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-dipropyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
-
-
?
3-[7-(2-carboxy-ethyl)-3,8,12,13,17,18-hexamethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-3,8,12,13,17,18-hexamethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
-
?
3-[7-(2-carboxy-ethyl)-3,8,12,13,17,18-hexamethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-3,8,12,13,17,18-hexamethyl-porphyrinogen-2-yl]-propionic acid + CO2 + CO2
-
-
-
-
?
3-[7-vinyl-17-(2-carboxy-ethyl)-13-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[2,7-divinyl-13-benzyl-3,8,12,18-tetramethyl-porphyrinogen-17-yl]-propionic acid + CO2
-
-
-
?
4,4'-[7,12-bis(2-carboxyethyl)-3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,18-diyl]dibutanoic acid + O2 + 2 H+
? + 2 CO2 + 2 H2O
5,10,15,20,22,24-hexahydro-3,7,13,18-tetramethyl-21H,23H-porphine-2,8,12,17-tripropanoic acid 17-methyl ester + O2
? + CO2
-
very poor substrate
-
?
harderoporphyrinogen + O2 + 2 H+
protoporphyrinogen + CO2 + H2O
substrate undergoes only the second decarboxylation
-
-
?
harderoporphyrinogen-VII + O2 + 2 H+
?
-
a monovinyl intermediate in the metabolism of coproporphyrinogen-IV
-
-
?
mesoporphyrinogen-VI + O2 + H+
? + CO2 + H2O
substrate undergoes only the first oxidative decarboxylation
-
-
?
pentacarboxylate porphyrinogen 5dab + O2
dehydroisocoproporphyrinogen
-
poorer substrate than coproporphyrinogen-III
-
-
?
pentacarboxylate porphyrinogen III + O2
dehydroisocoproporphyrinogen + CO2
-
half of the activity compared to coproporphyrinogen oxidase-III
-
?
protoporphyrinogen-IX + O2
protoporphyrin IX + CO2
-
capacity to oxidize not only coproporphyrinogen-III but also protoporphyrinogen-IX
-
?
protoporphyrinogen-IX + O2
protoporphyrin-IX + CO2
-
capacity to oxidize not only coproporphyrinogen-III but also protoporphyrinogen-IX
-
?
17-ethylprotoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
17-ethylharderoporphyrinogen-III + O2 + 2 H+
17-ethylprotoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
3-[7-vinyl-13,17-diethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
-
?
3-[7-(2-carboxy-ethyl)-13,17-diethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-diethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
-
-
-
-
?
4,4'-[7,12-bis(2-carboxyethyl)-3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,18-diyl]dibutanoic acid + O2 + 2 H+
? + 2 CO2 + 2 H2O
-
-
major product is a monovinylporphyrinogen, but some divinyl product is also generated. The incubation products are converted into the corresponding porphyrin methyl esters, and characterized by proton NMR spectroscopy and mass spectrometry
-
?
4,4'-[7,12-bis(2-carboxyethyl)-3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,18-diyl]dibutanoic acid + O2 + 2 H+
? + 2 CO2 + 2 H2O
-
-
major product is a monovinylporphyrinogen, but some divinyl products are also generated. The incubation products are converted into the corresponding porphyrin methyl esters, and characterized by proton NMR spectroscopy and mass spectrometry
-
?
protoporphyrinogen IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
recombinant Sll1185 shows CPO activity under both aerobic and anaerobic conditions
-
-
?
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
two oxidative decarboxylations sequentially to give a monovinylporphyrinogen intermediate. Regiospecific generation of harderoporphyrinogen as an intermediate by first converting the A ring side chain to a vinyl unit. Type isomers of coproporphyrinogen, overview
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
via harderoporphyrinogen intermediate production, overall reaction
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
two oxidative decarboxylations sequentially to give a monovinylporphyrinogen intermediate Regiospecific generation of harderoporphyrinogen as an intermediate by first converting the A ring side chain to a vinyl unit. Type isomers of coproporphyrinogen, overview
-
-
?
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
protoporphyrinogen IX + CO2 + H2O
-
-
-
?
coproporphyrinogen III + O2 + H+
protoporphyrinogen IX + CO2 + H2O
-
-
-
?
protoporphyrinogen-IX + 2 CO2 + 2 NADPH + 2 H+
-
oxidation under anaerobic conditions strictly requires NADP+ as electron acceptor
-
?
coproporphyrinogen-III + 2 NADP+
protoporphyrinogen-IX + 2 CO2 + 2 NADPH + 2 H+
-
oxidation under anaerobic conditions strictly requires NADP+ as electron acceptor
-
?
protoporphyrinogen-IX + ?
-
anaerobic oxidation only in the presence of ATP, NADP+, Mg2+, L-Met, 5-10% of the aerobic activity
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
Chromatium sp.
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
?
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
-
anaerobic enzyme, presence of Mg2+, L-Met, ATP, NADH and NADP+
-
?
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
essential enzyme, catalyzes the 6th step in heme biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
O2-dependent enzyme Hem13p
-
-
?
protoporphyrinogen-IX + CO2 + H2O
-
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
enzyme is involved in heme and chlorophyll biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
step in heme biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
HemF is absolutely dependent on oxygen
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
pathway overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
coproporphyrinogen analogues with modified propionate side chains bearing methyl substitutents are moderate substrates for the enzyme giving divinylic products, overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
pathway overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
6th step in heme biosynthesis, pathway overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
key enzyme in the biosynthesis of heme, metabolism overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
conversion of 2 propionate groups to 2 vinyl groups by oxidative decarboxylation
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
coproporphyrinogen conversion via tripropionate intermediate harderoporphyrinogen, selective conversion of propionate residues at the A and B rings into vinyl moieties by oxidation and decarboxylation resulting in a trivinylic compound
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
sequential oxidative decarboxylations at the A and B rings, synthetic coproporphyrinogen analogues with modified methylated propionate side chains are moderate substrates for the enzyme giving divinylic products, overview
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
enzyme is involved in heme and chlorophyll biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
6th step in heme biosynthesis
-
-
?
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
-
enzyme catalyzes the 6th step in heme biosynthesis, heme might be a feed-back regulator of its synthesis by inhibiting the import of th enzyme into mitochondria
-
-
?
harderoporphyrinogen + CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
harderoporphyrinogen + CO2 + 2 H2O
-
-
-
?
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
highly specific for oxygen as electron acceptor
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
Chromatium sp.
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
Chromatium sp.
-
highly specific for oxygen as electron acceptor
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
highly specific for oxygen as electron acceptor
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
oxygen-independent enzyme has also an aerobic function
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
acts on analogues which possess normal substituents on ring-A to generate a vinyl group on that ring, not active if the ring-A propionate group is changed
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
Arg400, Arg262 and Arg401 are active amino acids critical for substrate binding and/or catalysis, Arg262 and 401 may coordinate carboxylate groups of coproporphyrinogen-III, while Asp400 may initiate deprotonation of substrate, resulting in oxidative decarboxylation
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
small amount of the monovinyl intermediate
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
CPO converts coproporphyrinogen III to protoporphyrinogen IX through harderoporphyrinogen IX
-
-
ir
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
O2 is added to the (preferentially deprotonated) pyrrole substrate (yielding a hydroperoxide, which then abstracts a proton from the reactive propionate substituent), the reaction may then proceed through HO2- elimination, followed by decarboxylation
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
sixths enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
sixths enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
6th enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
6th enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
step-wise decarboxylation of 2- and 4-propionate substituents, both decarboxylations take place at the same active centre
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
highly specific for oxygen as electron acceptor
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
sixths enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
6th enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
same activity under aerobic and anaerobic conditions
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
aerobic and anaerobic oxidation catalyzed by the same enzyme
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
sixths enzyme in heme biosynthetic pathway
-
?
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
6th enzyme in heme biosynthetic pathway
-
?
protoporphyrinogen IX + 2 CO2 + 2 H2O
-
-
-
-
?
coproporphyrinogen-III + O2 + 2H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
CPO catalyzes the conversion of coproporphyrinogen-III to protoporphyrinogen-IX, a divinyl product, via two sequential oxidative decarboxylations of the A and B ring propionates
-
-
?
?
-
synthetic coproporphyrinogen analogues with modified propionate side chains
-
-
?
coproporphyrinogen-IV + O2
?
-
synthetic coproporphyrinogen analogues with modified propionate side chains
-
-
?
coproporphyrinogen-IV + O2
protoporphyrinogen-XIII + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-IV + O2
protoporphyrinogen-XIII + 2 CO2 + 2 H2O
-
-
-
?
coproporphyrinogen-IV + O2
protoporphyrinogen-XIII + 2 CO2 + 2 H2O
-
monovinyl intermediate that accumulates before being converted to an isomer
-
-
?
protoporphyrinogen IX + CO2 + H2O2
-
30% higher activity compared to coproporphyrinogen-III
-
?
harderoporphyrinogen + O2
protoporphyrinogen IX + CO2 + H2O2
-
intermediate of coproporphyrinogen-III, that is also a substrate
-
?
protoporphyrinogen-IX + CO2 + 2 H2O
-
-
-
?
harderoporphyrinogen + O2 + 2 H+
protoporphyrinogen-IX + CO2 + 2 H2O
-
-
-
?
protoporphyrinogen IX + CO2 + H2O2
-
-
-
r
protoporphyrinogen IX + CO2 + H2O2
-
3% of the activity compared to coproporphyrinogen-III
-
?
isoharderoporphyrinogen + O2
protoporphyrinogen IX + CO2 + H2O2
-
intermediate of coproporphyrinogen-III that is also a substrate
-
?
protoaetioporphyrin + 2 CO2 + 2 H2O
-
similar oxidation rate compared to coproporphyrinogen-III
-
?
mesoporphyrinogen-VI + O2 + 2 H+
protoaetioporphyrin + 2 CO2 + 2 H2O
-
-
-
?
mesoporphyrinogen-VI + O2 + 2 H+
protoaetioporphyrin + 2 CO2 + 2 H2O
-
-
-
r
?
-
synthetic coproporphyrinogen analogues with modified propionate side chains
-
-
?
mesoproporphyrinogen-VI + O2
?
-
synthetic coproporphyrinogen analogues with modified propionate side chains
-
-
?
?
-
-
no activity of HemF with protoporphyrinogen-IX and coporphyrinogen-III
-
-
?
additional information
?
-
-
substrate specificity with diverse coproporphyrinogen-derived compounds, overview, alterations of substituents involved in secondary binding interactions have a comparable affect to modifying the side chain that undergoes degradation at the catalytic site, porphyrinogen carboxylic acids are unstable, no hyroxylated products
-
-
?
additional information
?
-
-
substrate specificity with diverse coproporphyrinogen-derived compounds, overview, alterations of substituents involved in secondary binding interactions have a comparable affect to modifying the side chain that undergoes degradation at the catalytic site, no hyroxylated products
-
-
?
additional information
?
-
-
a nonnatural type I isomer of harderoporphyrinogen is also a substrate of CPO, no activity with 13-ethyl harderoporphyrinogen-III, substrate specificity with vinylic porphyrinogen derivatives, harderoporphyrinogen derivatives, and reaction mechanism, detailed overview
-
-
?
additional information
?
-
-
porphyrinogen 3,3'-[13,17-bis(carboxymethyl)-3,8,12,18-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,7-diyl]dipropanoic acid proves to be a relatively poor substrate for CPO compared to the natural substrate coproporphyrinogen-III, and only the A ring propionate moiety is processed to a significant extent
-
-
?
additional information
?
-
-
pentacarboxylate porphyrinogens 5abc, 5abd, and 5acd are not metabolized
-
-
?
additional information
?
-
-
porphyrinogen 3,3'-[13,17-bis(carboxymethyl)-3,8,12,18-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,7-diyl]dipropanoic acid proves to be a relatively poor substrate for CPO compared to the natural substrate coproporphyrinogen-III, and only the A ring propionate moiety is processed to a significant extent. Substrate recognition and catalysis, overview
-
-
?
additional information
?
-
-
the 17-ethyl analogue of harderoporphyrinogen-III, but not its 13-ethyl isomer, is an excellent substrate for the enzyme in accord with a proposed model for the active site of the enzyme. Harderoporphyrinogen-VII, the monovinyl intermediate in the metabolism of coproporphyrinogen-IV, is an equally good substrate
-
-
?
additional information
?
-
-
no activity with S-adenosylmethionine or without O2
-
-
?
additional information
?
-
-
deleterious enzyme mutations can cause hereditary coproporphyria
-
-
?
additional information
?
-
-
the 17-ethyl analogue of harderoporphyrinogen-III, but not its 13-ethyl isomer, is an excellent substrate for the enzyme in accord with a proposed model for the active site of the enzyme. Harderoporphyrinogen-VII, the monovinyl intermediate in the metabolism of coproporphyrinogen-IV, is an equally good substrate
-
-
?
additional information
?
-
no anaerobic activity is detected using NADP+ and S-adenosylmethionine
-
-
?
additional information
?
-
-
no anaerobic activity is detected using NADP+ and S-adenosylmethionine
-
-
?
additional information
?
-
-
HemJ is functionally coupled with the enzyme
-
-
-