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1.3.3.3: coproporphyrinogen oxidase

This is an abbreviated version!
For detailed information about coproporphyrinogen oxidase, go to the full flat file.

Word Map on EC 1.3.3.3

Reaction

Coproporphyrinogen III
+
O2
+ 2 H+ =
protoporphyrinogen-IX
+ 2 CO2 + 2 H2O

Synonyms

copro'gen oxidase, Coprogen oxidase, coproporphyinogen oxidase, coproporphyrinogen III oxidase, coproporphyrinogen oxidase, coproporphyrinogen-III oxidase, coproporphyrinogenase, COX, CPgen oxidase, CPGox, CPO, CPO III oxidase, CPOX, CPOX4, CPX, CPX1, CPX2, HEM13, Hem13p, HemF, HEMN1, KlHEM13, LIN2, LMM2, O2-dependent coproporphyrinogen III oxidase, oxygen-dependent coproporphyrinogen III oxidase, oxygen-dependent coproporphyrinogen-III oxidase, Sll1185

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.3 With oxygen as acceptor
                1.3.3.3 coproporphyrinogen oxidase

Substrates Products

Substrates Products on EC 1.3.3.3 - coproporphyrinogen oxidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
17-(3-carboxypropyl)-5,10,15,20,22,24-hexahydro-3,7,13,18-tetramethyl-21H,23H-porphine-2,8,12-tripropanoic acid + O2
? + CO2
show the reaction diagram
-
generates a vinyl group on ring-A
-
?
17-ethyl harderoporphyrinogen-III + O2 + 2 H+
?
show the reaction diagram
-
-
-
-
?
17-ethylharderoporphyrinogen-III + O2 + 2 H+
17-ethylprotoporphyrinogen-IX + 2 CO2 + 2 H2O
show the reaction diagram
2,4-bis-(beta-hydroxypropionic acid) deuteroporphyrinogen IX + O2
protoporphyrinogen IX + CO2
show the reaction diagram
-
one sixth of the rate compared to coproporhyrinogen-III
-
?
2-beta-hydroxypropionic acid-4-propionic acid deuteroporphyrinogen IX + O2
protoporphyrinogen IX + CO2
show the reaction diagram
-
80% of the activity compared to coproporphyrinogen-III
-
?
2-propionic acid-4-beta-hydroxypropionic acid deuteroporphyrinogen IX + O2
protoporphyrinogen IX + CO2
show the reaction diagram
-
8% of the activity compared to coproporphyrinogen-III
-
?
3-[7,13-di(2-carboxy-ethyl)-17-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13-(2-carboxy-ethyl)-17-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
show the reaction diagram
-
-
-
?
3-[7,13-di(2-carboxy-ethyl)-17-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13-(2-carboxy-ethyl)-17-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + 3-[7,13-divinyl-17-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
show the reaction diagram
-
-
-
-
?
3-[7,17-di(2-carboxy-ethyl)-13-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-17-(2-carboxy-ethyl)-13-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
show the reaction diagram
-
-
-
?
3-[7,17-di(2-carboxy-ethyl)-13-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-17-(2-carboxy-ethyl)-13-ethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
show the reaction diagram
-
-
-
-
?
3-[7-(2-carboxy-ethyl)-13,17-di-tert-butyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-di-tert-butyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
show the reaction diagram
-
-
-
?
3-[7-(2-carboxy-ethyl)-13,17-dibutyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-dibutyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
show the reaction diagram
-
-
-
-
?
3-[7-(2-carboxy-ethyl)-13,17-diethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-diethyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
show the reaction diagram
3-[7-(2-carboxy-ethyl)-13,17-diisopropyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-diisopropyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
show the reaction diagram
-
-
-
?
3-[7-(2-carboxy-ethyl)-13,17-dipropyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-13,17-dipropyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + CO2
show the reaction diagram
-
-
-
-
?
3-[7-(2-carboxy-ethyl)-3,8,12,13,17,18-hexamethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-3,8,12,13,17,18-hexamethyl-porphyrinogen-2-yl]-propionic acid + CO2
show the reaction diagram
-
-
-
?
3-[7-(2-carboxy-ethyl)-3,8,12,13,17,18-hexamethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[7-vinyl-3,8,12,13,17,18-hexamethyl-porphyrinogen-2-yl]-propionic acid + CO2 + CO2
show the reaction diagram
-
-
-
-
?
3-[7-vinyl-17-(2-carboxy-ethyl)-13-benzyl-3,8,12,18-tetramethyl-porphyrinogen-2-yl]-propionic acid + O2
3-[2,7-divinyl-13-benzyl-3,8,12,18-tetramethyl-porphyrinogen-17-yl]-propionic acid + CO2
show the reaction diagram
-
-
-
?
4,4'-[7,12-bis(2-carboxyethyl)-3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,18-diyl]dibutanoic acid + O2 + 2 H+
? + 2 CO2 + 2 H2O
show the reaction diagram
5,10,15,20,22,24-hexahydro-3,7,13,18-tetramethyl-21H,23H-porphine-2,8,12,17-tripropanoic acid 17-methyl ester + O2
? + CO2
show the reaction diagram
-
very poor substrate
-
?
coproporphyrinogen III + O2
coproporphyrin III + H2O
show the reaction diagram
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
show the reaction diagram
coproporphyrinogen III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
show the reaction diagram
coproporphyrinogen III + O2 + H+
protoporphyrinogen IX + CO2 + H2O
show the reaction diagram
coproporphyrinogen-III + 2 NADP+
protoporphyrinogen-IX + 2 CO2 + 2 NADPH + 2 H+
show the reaction diagram
coproporphyrinogen-III + ?
protoporphyrinogen-IX + ?
show the reaction diagram
coproporphyrinogen-III + O2
protoporphyrinogen-IX + 2 CO2 + 2 H2O
show the reaction diagram
coproporphyrinogen-III + O2
protoporphyrinogen-IX + CO2 + H2O
show the reaction diagram
coproporphyrinogen-III + O2 + 2 H+
harderoporphyrinogen + CO2 + 2 H2O
show the reaction diagram
coproporphyrinogen-III + O2 + 2 H+
protoporphyrinogen-IX + 2 CO2 + 2 H2O
show the reaction diagram
coproporphyrinogen-III + O2 + 2H+
protoporphyrinogen IX + 2 CO2 + 2 H2O
show the reaction diagram
coproporphyrinogen-IV + O2
?
show the reaction diagram
coproporphyrinogen-IV + O2
protoporphyrinogen-XIII + 2 CO2 + 2 H2O
show the reaction diagram
harderoporphyrinogen + O2
protoporphyrinogen IX + CO2 + H2O2
show the reaction diagram
harderoporphyrinogen + O2 + 2 H+
protoporphyrinogen + CO2 + H2O
show the reaction diagram
substrate undergoes only the second decarboxylation
-
-
?
harderoporphyrinogen + O2 + 2 H+
protoporphyrinogen-IX + CO2 + 2 H2O
show the reaction diagram
harderoporphyrinogen + O2 + H+
protoporphyrinogen IX + CO2 + H2O2
show the reaction diagram
harderoporphyrinogen-III + O2 + 2 H+
?
show the reaction diagram
-
-
-
-
?
harderoporphyrinogen-IV + O2 + 2 H+
?
show the reaction diagram
-
-
-
-
?
harderoporphyrinogen-VII + O2 + 2 H+
?
show the reaction diagram
-
a monovinyl intermediate in the metabolism of coproporphyrinogen-IV
-
-
?
harderoporphyrinogen-VII + O2 + 2 H+
? + 2 CO2 + 2 H2O
show the reaction diagram
isoharderoporphyrinogen + O2
protoporphyrinogen IX + CO2 + H2O2
show the reaction diagram
isoharderoporphyrinogen + O2 + 2 H+
?
show the reaction diagram
-
very low activity
-
-
?
isoharderoporphyrinogen + O2 + 2 H+
? + 2 CO2 + 2 H2O
show the reaction diagram
mesoporphyrinogen-VI + O2 + 2 H+
protoaetioporphyrin + 2 CO2 + 2 H2O
show the reaction diagram
mesoporphyrinogen-VI + O2 + H+
? + CO2 + H2O
show the reaction diagram
substrate undergoes only the first oxidative decarboxylation
-
-
?
mesoproporphyrinogen-VI + O2
?
show the reaction diagram
pentacarboxylate porphyrinogen 5dab + O2
dehydroisocoproporphyrinogen
show the reaction diagram
-
poorer substrate than coproporphyrinogen-III
-
-
?
pentacarboxylate porphyrinogen III + O2
dehydroisocoproporphyrinogen + CO2
show the reaction diagram
-
half of the activity compared to coproporphyrinogen oxidase-III
-
?
protoporphyrinogen IX + O2
protoporphyrin IX + H2O
show the reaction diagram
-
-
-
-
?
protoporphyrinogen-IX + O2
protoporphyrin IX + CO2
show the reaction diagram
-
capacity to oxidize not only coproporphyrinogen-III but also protoporphyrinogen-IX
-
?
protoporphyrinogen-IX + O2
protoporphyrin-IX + CO2
show the reaction diagram
-
capacity to oxidize not only coproporphyrinogen-III but also protoporphyrinogen-IX
-
?
additional information
?
-