1.3.1.92: artemisinic aldehyde DELTA11(13)-reductase
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Word Map on EC 1.3.1.92
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1.3.1.92
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artemisinin
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annua
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artemisia
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trichomes
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cyp71av1
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amorpha-4,11-diene
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glandular
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trichome-specific
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antimalarial
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dihydroartemisinic
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hydroxylase
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malaria
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synthesis
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medicine
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drug development
- 1.3.1.92
- artemisinin
- annua
-
artemisia
- trichomes
- cyp71av1
- amorpha-4,11-diene
- glandular
-
trichome-specific
-
antimalarial
-
dihydroartemisinic
- hydroxylase
-
malaria
- synthesis
- medicine
- drug development
Reaction
Synonyms
artemisinic aldehyde DELTA11(13) double bond reductase2, artemisinic aldehyde DELTA11(13) double-bond reductase, artemisinic aldehyde DELTA11(13) reductase, Dbr2, double bond reductase 2, double-bond reductase 2
ECTree
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Expression
Expression on EC 1.3.1.92 - artemisinic aldehyde DELTA11(13)-reductase
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expression levels of farnesyl diphosphate synthase (FPS), cytochrome P450-dependent hydroxylase CYP71AV1, and double bond reductase 2 (DBR2) are increased significantly in plants overexpressing Artemisia annua allene oxide cyclase, AaAOC. The product of AOC is jasmonate, that induces the expression of FPS, CYP71AV1, and DBR2
methyljasmonate does not induce significant changes in the expression of DBR2
the enzyme DBR2 is induced by 0.12 mmol/l of cadmium. Appropriate doses of cadmium can increase the concentrations of artemisinic metabolites at a certain time point by upregulating the relative expression levels of key enzyme genes involved in artemisinin biosynthesis, overview
three jasmonate-responsive transcription factors, ethylene response factor 1, ethylene response factor 2, and octadecanoidresponsive AP2/ERF, all transcriptionally activate the expression of artemisinin biosynthetic genes, such as amorpha-4,11-diene synthase (ADS), CYP71AV1, DBR2, and aldehyde dehydrogenase 1 (ALDH1). Cold stress indirectly activates the DBR2 expression by increasing the amount of jasmonate through upregulation of jasmonate biosynthetic genes (LOX1, LOX2, allene oxide cyclase [AOC], and jasmonate resistant 1 [JAR1]). Levels of artemisinin and related secondary metabolites, such as dihydroartemisinic acid, artemisinin B, and artemisinic acid, are increased in Artemisia annua under cold stress
treatment for 30 min and 4 h with miconazole induces about four- und fivefold upregulation of the DBR2 gene, respectively