1.3.1.92: artemisinic aldehyde DELTA11(13)-reductase

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Reaction

Synonyms

artemisinic aldehyde DELTA11(13) double bond reductase2, artemisinic aldehyde DELTA11(13) double-bond reductase, artemisinic aldehyde DELTA11(13) reductase, Dbr2, double bond reductase 2, double-bond reductase 2

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.92 artemisinic aldehyde DELTA11(13)-reductase

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1	Activating Compound
1	AA Sequence
4	Application
8	Cloned(Commentary)
8	Cofactor
6	Expression
4	General Information
5	kcat/KM [mM/s]
5	KM Value [mM]
1	Localization
1	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
14	Organism
3	Pathway
4	PDB ID
1	pH Optimum
2	pH Range
3	Protein Variants
1	Purification (Commentary)
1	Reaction
14	Reference
15	Source Tissue
19	Substrates and Products (Substrate)
17	Synonyms
1	Systematic Name
5	Turnover Number [1/s]

Application

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Application on EC 1.3.1.92 - artemisinic aldehyde DELTA11(13)-reductase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug development

Artemisia annua

C5H429

oral feeding of whole intact plant cells bioencapsulating the artemisinin reduces the Plasmodium falciparum parasitemia levels in challenged mice in comparison with commercial drug. The synergistic approache may facilitate low-cost production and delivery of artemisinin and other drugs through metabolic engineering of edible plants

745811

medicine

Artemisia annua

C5H429

artemisinin is the main ingredient for malaria prevention. The World Health Organization recommends artemisinin combination therapies (ACT) as the first-line therapy for malaria worldwide

744971

synthesis

2 entries

synthesis

Artemisia annua

-

production of artemisin by incubating a mixture of artemisin precursors from engineered Saccharomyces cerevisiae with a cell-free extract of Artemisia annua. Use of cold-acclimated Artemisia annua cell-free extract gives rise to considerable artemisin content up to 0.65%

717175

synthesis

Artemisia annua

C5H429

for enhanced artemisin production, Appropriate doses of Cd can increase the concentrations of artemisinic metabolites at a certain time point by upregulating the relative expression levels of key enzyme genes involved in artemisinin biosynthesis

744971