1.3.1.91: tRNA-dihydrouridine20 synthase [NAD(P)+]

This is an abbreviated version!
For detailed information about tRNA-dihydrouridine20 synthase [NAD(P)+], go to the full flat file.

Reaction

Synonyms

dihydrouridine synthase, dihydrouridine synthase 2, dihydrouridine synthase C, Dus, DUS 2, DUS2, Dus2p, DusA, DusB, DusC, EcoDusC, hDUS2, HsDus2, SMM1, tRNA-dihydrouridine synthase 2, tRNA-dihydrouridine synthases

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.91 tRNA-dihydrouridine20 synthase [NAD(P)+]

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Results	in table
12748	AA Sequence
3	Application
9	Cloned(Commentary)
13	Cofactor
5	Crystallization (Commentary)
24	Disease/ Diagnostics
1	Expression
12	General Information
1	KM Value [mM]
1	Localization
1	Metals/Ions
1	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
12	Organism
2	pH Optimum
5	Protein Variants
9	Purification (Commentary)
3	Reaction
12	Reference
3	Source Tissue
25	Substrates and Products (Substrate)
7	Subunits
28	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
1	Turnover Number [1/s]

Application

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Application on EC 1.3.1.91 - tRNA-dihydrouridine20 synthase [NAD(P)+]

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

diagnostics

Homo sapiens

Q9NX74

the enzyme defined as an independent prognostic factor for the development of non-small cell lung cancer cells

743940

medicine

2 entries

medicine

Homo sapiens

Q9NX74

upregulation of hDUS2 is a relatively common feature of pulmonary carcinogenesis. Selective suppression of hDUS2 enzyme activity and/or inhibition of formation of the hDUS2-tRNA synthetase complex could be a promising therapeutic strategy for treatment of many lung cancers. Significant association between higher levels of hDUS2 in tumors and poorer prognosis of lung cancer patients

711663

medicine

Homo sapiens

Q9NX74

the enzyme may serve as a valuable target for therapeutic intervention in pulmonary carcinogenesis

743940