1.3.1.85: crotonyl-CoA carboxylase/reductase

This is an abbreviated version!
For detailed information about crotonyl-CoA carboxylase/reductase, go to the full flat file.

Reaction

Synonyms

2-octenoyl-CoA carboxylase/reductase, AntE, CCR, CCR1, CCRC, crotonyl-CoA carboxylase/reductase, crotonyl-CoA reductase (carboxylating), crotonyl-CoA reductase-carboxylase, ECR, enoyl-CoA carboxylase/reductase, pteB, rimJ

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.85 crotonyl-CoA carboxylase/reductase

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Results	in table
1	Activating Compound
1643	AA Sequence
5	Cloned(Commentary)
17	Cofactor
2	Crystallization (Commentary)
5	Expression
7	General Information
10	kcat/KM [mM/s]
38	KM Value [mM]
2	Metals/Ions
6	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
38	Organism
7	Pathway
2	pH Optimum
22	Protein Variants
4	Purification (Commentary)
1	Reaction
8	Reaction Type
22	Reference
3	Source Tissue
53	Substrates and Products (Substrate)
4	Subunits
36	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
30	Turnover Number [1/s]

KM Value

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KM Value on EC 1.3.1.85 - crotonyl-CoA carboxylase/reductase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.2

(2S)-ethylmalonyl-CoA

Cereibacter sphaeroides 2.4.1

-

in 100 mM Tris-HCl buffer (pH 7.9), temperature not specified in the publication

689745

0.2 - 0.4

(E)-crotonyl-CoA

2 entries

0.14 - 0.2

4-coumaroyl-CoA

2 entries

0.5

acryloyl-CoA

Cereibacter sphaeroides

-

pH and temperature not specified in the publication

713409

0.089 - 0.38

cinnamoyl-CoA

2 entries

0.03 - 1.31

CO2

8 entries

0.01 - 1.58

crotonyl-CoA

13 entries

0.011 - 0.7

NADPH

9 entries

0.2

(E)-crotonyl-CoA

Cereibacter sphaeroides

-

for reduction, pH and temperature not specified in the publication

713409

0.4

(E)-crotonyl-CoA

Cereibacter sphaeroides

-

for reductive carboxylation, pH and temperature not specified in the publication

713409

0.14

4-coumaroyl-CoA

Streptomyces sp.

M1SQA1

mutant enzyme V350A, pH and temperature not specified in the publication

739852

0.2

4-coumaroyl-CoA

Streptomyces sp.

M1SQA1

mutant enzyme V350G, pH and temperature not specified in the publication

739852

0.089

cinnamoyl-CoA

Streptomyces sp.

M1SQA1

mutant enzyme V350G, pH and temperature not specified in the publication

739852

0.38

cinnamoyl-CoA

Streptomyces sp.

M1SQA1

wild type enzyme, pH and temperature not specified in the publication

739852

0.03

CO2

Kitasatospora setae

E4N096

mutant enzyme T82D, at pH 8.0 and 30°C

760072

0.08

CO2

Kitasatospora setae

E4N096

mutant enzyme S119A, at pH 8.0 and 30°C

760072

0.09

CO2

Kitasatospora setae

E4N096

wild type enzyme, at pH 8.0 and 30°C

760072

0.15

CO2

Kitasatospora setae

E4N096

mutant enzyme F170Y, at pH 8.0 and 30°C

760072

0.155

CO2

Kitasatospora setae

E4N096

mutant enzyme E171A, at pH 8.0 and 30°C

760072

0.2

CO2

Cereibacter sphaeroides

-

at pH 7.8, temperature not specified in the publication

713409

0.2

CO2

Cereibacter sphaeroides 2.4.1

-

in 100 mM Tris-HCl buffer (pH 7.9), temperature not specified in the publication

689745

1.31

CO2

Kitasatospora setae

E4N096

mutant enzyme H365N, at pH 8.0 and 30°C

760072

0.01

crotonyl-CoA

Kitasatospora setae

E4N096

mutant enzyme F170Y, at pH 8.0 and 30°C

760072

0.0134

crotonyl-CoA

Kitasatospora setae

E4N096

mutant enzyme T82D, at pH 8.0 and 30°C

760072

0.021

crotonyl-CoA

Kitasatospora setae

E4N096

wild type enzyme, at pH 8.0 and 30°C

760072

0.0298

crotonyl-CoA

Kitasatospora setae

E4N096

mutant enzyme H365N, at pH 8.0 and 30°C

760072

0.031

crotonyl-CoA

Kitasatospora setae

E4N096

mutant enzyme F170A, at pH 8.0 and 30°C

760072

0.036

crotonyl-CoA

Kitasatospora setae

E4N096

mutant enzyme S119A, at pH 8.0 and 30°C

760072

0.4

crotonyl-CoA

Cereibacter sphaeroides 2.4.1

-

in 100 mM Tris-HCl buffer (pH 7.9), temperature not specified in the publication

689745

0.49

crotonyl-CoA

Streptomyces sp.

M1SQA1

mutant enzyme V350F, pH and temperature not specified in the publication

739852

0.5

crotonyl-CoA

Kitasatospora setae

E4N096

mutant enzyme E171A, at pH 8.0 and 30°C

760072

1.17

crotonyl-CoA

Streptomyces sp.

M1SQA1

mutant enzyme V350G, pH and temperature not specified in the publication

739852

1.21

crotonyl-CoA

Streptomyces sp.

M1SQA1

mutant enzyme V350A, pH and temperature not specified in the publication

739852

1.31

crotonyl-CoA

Streptomyces sp.

M1SQA1

mutant enzyme A182L, pH and temperature not specified in the publication

739852

1.58

crotonyl-CoA

Streptomyces sp.

M1SQA1

wild type enzyme, pH and temperature not specified in the publication

739852

0.011

NADPH

Kitasatospora setae

E4N096

mutant enzyme F170A, at pH 8.0 and 30°C

760072

0.022

NADPH

Kitasatospora setae

E4N096

mutant enzyme H365N, at pH 8.0 and 30°C

760072

0.03

NADPH

Kitasatospora setae

E4N096

mutant enzyme S119A, at pH 8.0 and 30°C

760072

0.036

NADPH

Kitasatospora setae

E4N096

mutant enzyme F170Y, at pH 8.0 and 30°C

760072

0.037

NADPH

Kitasatospora setae

E4N096

wild type enzyme, at pH 8.0 and 30°C

760072

0.052

NADPH

Kitasatospora setae

E4N096

mutant enzyme T82D, at pH 8.0 and 30°C

760072

0.112

NADPH

Kitasatospora setae

E4N096

mutant enzyme E171A, at pH 8.0 and 30°C

760072

0.7

NADPH

Cereibacter sphaeroides

-

pH and temperature not specified in the publication

713409

0.7

NADPH

Cereibacter sphaeroides 2.4.1

-

in 100 mM Tris-HCl buffer (pH 7.9), temperature not specified in the publication

689745