1.3.1.84: acrylyl-CoA reductase (NADPH)
This is an abbreviated version!
For detailed information about acrylyl-CoA reductase (NADPH), go to the full flat file.
Word Map on EC 1.3.1.84
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1.3.1.84
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propionyl-coa
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acrylate
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acuis
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3-hydroxypropionate
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3-hydroxypropionyl-coa
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dehydratase
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chloroflexus
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sedula
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crotonyl-coa
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aurantiacus
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ruegeria
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dimethylsulfoniopropionate
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metallosphaera
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3-hydroxypropionate/4-hydroxybutyrate
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hyper-sensitive
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pomeroyi
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lyases
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dmdas
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ethylmalonyl-coa
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sphaeroides
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roseobacters
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succinyl-coa
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synthesis
- 1.3.1.84
- propionyl-coa
- acrylate
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acuis
- 3-hydroxypropionate
- 3-hydroxypropionyl-coa
- dehydratase
- chloroflexus
- sedula
- crotonyl-coa
- aurantiacus
- ruegeria
- dimethylsulfoniopropionate
- metallosphaera
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3-hydroxypropionate/4-hydroxybutyrate
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hyper-sensitive
- pomeroyi
- lyases
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dmdas
- ethylmalonyl-coa
- sphaeroides
- roseobacters
- succinyl-coa
- synthesis
Reaction
Synonyms
Acr, acryloyl-CoA reductase, acryloyl-CoA reductase (NADPH), acryloyl-coenzyme A reductase, acrylyl-CoA reductase, acrylyl-coenzyme A reductase, AcuI, Msed_1426, NADPH-dependent acryloyl-CoA reductase activity, NADPH-dependent acrylyl-CoA reductase, RSP_1434, SPO1914, SPO_1914, yhdH
ECTree
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Substrates Products
Substrates Products on EC 1.3.1.84 - acrylyl-CoA reductase (NADPH)
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REACTION DIAGRAM
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the enzyme is highly specific for NADPH with catalytic efficiencies of more than 10fold higher for NADPH than for NADH
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additional information
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the enzyme is highly specific for NADPH with catalytic efficiencies of more than 10fold higher for NADPH than for NADH
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-
?
additional information
?
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the enzyme shows less than 1% activity with crotonyl-CoA, 3-hydroxypropionyl-CoA and acrylate
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?
additional information
?
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the enzyme shows less than 1% activity with crotonyl-CoA, 3-hydroxypropionyl-CoA and acrylate
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?
additional information
?
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no activity with crotonyl-CoA. AcuI also does not catalyze reduction of acrylate or dehydration/reduction of 3-hydroxypropionyl-CoA
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?
additional information
?
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no activity with crotonyl-CoA. AcuI also does not catalyze reduction of acrylate or dehydration/reduction of 3-hydroxypropionyl-CoA
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?
additional information
?
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Cereibacter sphaeroides DSM 158
the enzyme is highly specific for NADPH with catalytic efficiencies of more than 10fold higher for NADPH than for NADH
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?
additional information
?
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Cereibacter sphaeroides DSM 158
the enzyme shows less than 1% activity with crotonyl-CoA, 3-hydroxypropionyl-CoA and acrylate
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-
?
additional information
?
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the enzyme is highly specific for NADPH with catalytic efficiencies of more than 10fold higher for NADPH than for NADH
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-
?
additional information
?
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the enzyme shows less than 1% activity with crotonyl-CoA, 3-hydroxypropionyl-CoA and acrylate
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-
?
additional information
?
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the enzyme shows a low but detectable activity for NADPH-dependent crotonyl-CoA reduction
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?
additional information
?
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the enzyme shows a low but detectable activity for NADPH-dependent crotonyl-CoA reduction
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?
additional information
?
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the enzyme activity is assayed coupled to 3-hydroxypropionyl-CoA synthetase (AMP-forming)
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?
additional information
?
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the enzyme activity is assayed coupled to 3-hydroxypropionyl-CoA synthetase (AMP-forming)
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additional information
?
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the purified proteins of malonyl-CoA reductase (MCR) and 3-hydroxypropionyl-CoA dehydratase (3HPCD) from Sulfolobus tokodaii, and the proteins of malonate semialdehyde reductase (MSR), 3-hydroxypropionyl-CoA synthetase (3HPCS), and acryloyl-CoA reductase (ACR) from Metallosphaera sedula are used to convert malonyl-CoA to propionyl-CoA in vitro. Malonyl-CoA is almost completely converted to propionyl-CoA even at 23°C, and no other acyl-CoA products are detected, indicating that this system is robust. The turnover rate of this pathway is 37/min at 37°C
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?
additional information
?
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the purified proteins of malonyl-CoA reductase (MCR) and 3-hydroxypropionyl-CoA dehydratase (3HPCD) from Sulfolobus tokodaii, and the proteins of malonate semialdehyde reductase (MSR), 3-hydroxypropionyl-CoA synthetase (3HPCS), and acryloyl-CoA reductase (ACR) from Metallosphaera sedula are used to convert malonyl-CoA to propionyl-CoA in vitro. Malonyl-CoA is almost completely converted to propionyl-CoA even at 23°C, and no other acyl-CoA products are detected, indicating that this system is robust. The turnover rate of this pathway is 37/min at 37°C
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-
?
additional information
?
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the purified proteins of malonyl-CoA reductase (MCR) and 3-hydroxypropionyl-CoA dehydratase (3HPCD) from Sulfolobus tokodaii, and the proteins of malonate semialdehyde reductase (MSR), 3-hydroxypropionyl-CoA synthetase (3HPCS), and acryloyl-CoA reductase (ACR) from Metallosphaera sedula are used to convert malonyl-CoA to propionyl-CoA in vitro. Malonyl-CoA is almost completely converted to propionyl-CoA even at 23°C, and no other acyl-CoA products are detected, indicating that this system is robust. The turnover rate of this pathway is 37/min at 37°C
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-
?
additional information
?
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the enzyme activity is assayed coupled to 3-hydroxypropionyl-CoA synthetase (AMP-forming)
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-
?
additional information
?
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the enzyme is highly specific for NADPH with catalytic efficiencies of more than 10fold higher for NADPH than for NADH
-
-
?
additional information
?
-
-
the enzyme is highly specific for NADPH with catalytic efficiencies of more than 10fold higher for NADPH than for NADH
-
-
?
additional information
?
-
the enzyme shows less than 1% activity with crotonyl-CoA, 3-hydroxypropionyl-CoA and acrylate
-
-
?
additional information
?
-
-
the enzyme shows less than 1% activity with crotonyl-CoA, 3-hydroxypropionyl-CoA and acrylate
-
-
?
additional information
?
-
the enzyme shows a low but detectable activity for NADPH-dependent crotonyl-CoA reduction
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-
?
additional information
?
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the enzyme shows a low but detectable activity for NADPH-dependent crotonyl-CoA reduction
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-
?
additional information
?
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the partially purified recombinant protein has activity of acryloyl-CoA reductase but not 3-hydroxypropionyl-CoA reductase. The 3-hydroxypropionyl-CoA reductase activity observed in cell extracts results from the coupling of the acryloyl-CoA hydratase with an acryloyl-CoA reductase activity
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?
additional information
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no substrate: NADH, crotonyl-CoA
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