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24-methylenecholesterol + NADPH + H+
campesterol + NADP+
5alpha-cholest-7-en-3beta-ol + NADP+
5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+
5alpha-cholesta-7,24-dien-3beta-ol + NADPH
5alpha-cholest-7-en-3beta-ol + NADP+
5alpha-cholesta-7,24-dien-3beta-ol + NADPH
5alpha-cholesta-7-en-3beta-ol + NADP+
cholesta-5,24-dien-3beta-ol + NADPH + H+
cholest-5-en-3beta-ol + NADP+
cholesta-5,7,24-trien-3beta-ol + NADPH
cholest-5,7-dien-3beta-ol + NADP+
cholesta-5,7,24-trien-3beta-ol + NADPH + H+
7-dehydrocholesterol + NADP+
-
-
-
-
?
cholesta-7,24-dien-3beta-ol + NADPH + H+
lathosterol + NADP+
-
-
-
-
?
desmosterol + NADPH
cholesterol + NADP+
desmosterol + NADPH + H+
cholesterol + NADP+
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+
ergosterol + NADP+
lanosterol + NADPH
24-dihydrolanosterol + NADP+
lanosterol + NADPH + H+
4,4,14alpha-trimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
-
-
-
-
?
lanosterol + NADPH + H+
dihydrolanosterol + NADP+
-
-
-
-
?
zymosterol + NADPH + H+
zymostenol + NADP+
-
-
-
-
?
additional information
?
-
24-methylenecholesterol + NADPH + H+
campesterol + NADP+
-
-
-
?
24-methylenecholesterol + NADPH + H+
campesterol + NADP+
-
-
-
-
?
5alpha-cholest-7-en-3beta-ol + NADP+
5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+
-
-
-
-
?
5alpha-cholest-7-en-3beta-ol + NADP+
5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+
-
-
-
-
r
5alpha-cholesta-7,24-dien-3beta-ol + NADPH
5alpha-cholest-7-en-3beta-ol + NADP+
-
2 major alternate routes for cholesterol biosynthesis, step in the biosynthesis of cholesterol from lanosterol
-
-
?
5alpha-cholesta-7,24-dien-3beta-ol + NADPH
5alpha-cholest-7-en-3beta-ol + NADP+
-
step in the biosynthesis of cholesterol from lanosterol
-
-
?
5alpha-cholesta-7,24-dien-3beta-ol + NADPH
5alpha-cholest-7-en-3beta-ol + NADP+
-
step in the biosynthesis of cholesterol from lanosterol
-
-
?
5alpha-cholesta-7,24-dien-3beta-ol + NADPH
5alpha-cholesta-7-en-3beta-ol + NADP+
-
C-24 reduction of sterols probably takes place straight after sterol DELTA8-7 isomerization of zymosterol, which occurs several steps after C-32 demethylation of lanosterol in the 19-step pathway of cholesterol biosynthesis from lanosterol
-
-
?
5alpha-cholesta-7,24-dien-3beta-ol + NADPH
5alpha-cholesta-7-en-3beta-ol + NADP+
-
C-24 reduction of DELTA7,24-diene
-
-
?
5alpha-cholesta-7,24-dien-3beta-ol + NADPH
5alpha-cholesta-7-en-3beta-ol + NADP+
-
most reactive, probably natural substrate
-
-
?
cholesta-5,24-dien-3beta-ol + NADPH + H+
cholest-5-en-3beta-ol + NADP+
-
-
-
-
?
cholesta-5,24-dien-3beta-ol + NADPH + H+
cholest-5-en-3beta-ol + NADP+
-
-
-
?
cholesta-5,24-dien-3beta-ol + NADPH + H+
cholest-5-en-3beta-ol + NADP+
-
-
-
-
?
cholesta-5,24-dien-3beta-ol + NADPH + H+
cholest-5-en-3beta-ol + NADP+
-
-
-
?
cholesta-5,24-dien-3beta-ol + NADPH + H+
cholest-5-en-3beta-ol + NADP+
reduction of desmosterol to cholesterol is dependent on FAD
-
-
?
cholesta-5,24-dien-3beta-ol + NADPH + H+
cholest-5-en-3beta-ol + NADP+
-
reduction of desmosterol to cholesterol is dependent on FAD
-
-
?
cholesta-5,7,24-trien-3beta-ol + NADPH
cholest-5,7-dien-3beta-ol + NADP+
-
step in the biosynthesis of cholesterol from desmosterol
-
-
?
cholesta-5,7,24-trien-3beta-ol + NADPH
cholest-5,7-dien-3beta-ol + NADP+
-
step in the biosynthesis of cholesterol from lanosterol
-
-
?
cholesta-5,7,24-trien-3beta-ol + NADPH
cholest-5,7-dien-3beta-ol + NADP+
-
step in the biosynthesis of cholesterol from lanosterol
-
-
?
desmosterol + NADPH
cholesterol + NADP+
-
5alpha-cholesta-5,24-dien-3beta-ol
-
-
?
desmosterol + NADPH
cholesterol + NADP+
-
step in the biosynthesis of cholesterol from lanosterol
-
-
?
desmosterol + NADPH
cholesterol + NADP+
-
5alpha-cholesta-5,24-dien-3beta-ol
-
-
?
desmosterol + NADPH
cholesterol + NADP+
-
5alpha-cholesta-5,24-dien-3beta-ol
-
-
?
desmosterol + NADPH
cholesterol + NADP+
-
step in the biosynthesis of cholesterol from lanosterol
-
-
?
desmosterol + NADPH + H+
cholesterol + NADP+
-
-
-
-
?
desmosterol + NADPH + H+
cholesterol + NADP+
-
-
-
-
?
desmosterol + NADPH + H+
cholesterol + NADP+
-
-
-
-
?
desmosterol + NADPH + H+
cholesterol + NADP+
-
-
-
-
?
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+
ergosterol + NADP+
-
-
-
?
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+
ergosterol + NADP+
-
-
-
?
lanosterol + NADPH
24-dihydrolanosterol + NADP+
-
step in the biosynthesis of cholesterol from lanosterol
-
-
?
lanosterol + NADPH
24-dihydrolanosterol + NADP+
-
step in the biosynthesis of cholesterol from lanosterol
-
-
?
additional information
?
-
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the enzyme synthesizes cholesterol by transformation of dietary phytosterols through a dealkylation reaction
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-
?
additional information
?
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-
reduction of DELTA24 double bond is one of the necessary reactions during cholesterol synthesis
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-
?
additional information
?
-
-
cholesterogenic enzyme
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-
?
additional information
?
-
-
important enzyme in the 19-step pathway of cholesterol biosynthesis from lanosterol
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-
?
additional information
?
-
-
enzyme deficiency due to mutation cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis, patients show elevated levels of cholesterol precursor desmosterol in plasma and tissue
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-
?
additional information
?
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enzyme of phytosterol metabolism to cholesterol
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-
?
additional information
?
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reduction of 24,25-double bond
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-
?
additional information
?
-
-
insects are unable to synthesize sterols de novo and acquire sterols from their diet or from symbionts, sterol 24,25-reductase is an important enzyme of the pathway for the transformation of sitosterol, 24alpha-ethylcholesterol, together with stigmasterol, 24alpha-ethylcholesta-5,22-dien-3beta-ol, the predominant phytosterol in tobacco, to cholesterol
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-
?
additional information
?
-
-
anaerobic reduction of 24(25)-enes of lanosterol and other obligatory intermediates of cholesterol biosynthesis from lanosterol in mammals to produce 24(25)-dihydrosterols
-
-
?
additional information
?
-
-
C-24 reduction of sterols probably takes place straight after sterol DELTA8-7 isomerization of zymosterol, which occurs several steps after C-32 demethylation of lanosterol in the 19-step pathway of cholesterol biosynthesis from lanosterol
-
-
?
additional information
?
-
-
reduction of DELTA24 double bond is one of the necessary reactions during cholesterol synthesis
-
-
?
additional information
?
-
-
cholesterogenic enzyme
-
-
?
additional information
?
-
-
cholesterogenic enzyme
-
-
?
additional information
?
-
-
important enzyme in the 19-step pathway of cholesterol biosynthesis from lanosterol
-
-
?
additional information
?
-
-
important enzyme in the 19-step pathway of cholesterol biosynthesis from lanosterol
-
-
?