1.3.1.38: trans-2-enoyl-CoA reductase (NADPH)
This is an abbreviated version!
For detailed information about trans-2-enoyl-CoA reductase (NADPH), go to the full flat file.
Word Map on EC 1.3.1.38
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1.3.1.38
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beta-ketoacyl-coa
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beta-hydroxyacyl-coa
-
dehydrase
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palmitoyl-coa
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butyryl-coa
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condensing
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vlcfas
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nadph-specific
- 1.3.1.38
-
beta-ketoacyl-coa
-
beta-hydroxyacyl-coa
-
dehydrase
- palmitoyl-coa
- butyryl-coa
-
condensing
-
vlcfas
-
nadph-specific
Reaction
Synonyms
2-trans enoyl-ACP(CoA) reductase, ECR, EgTER1, enoyl reductase, InhA, MECR, MECR-1, mitochondrial 2-trans-enoyl-CoA/ACP reductase, mitochondrial 2-trans-enoyl-thioester reductase, NADPH-dependent trans-2-enoyl-CoA reductase, reductase, trans-enoyl coenzyme A, TER, trans-2-enoyl-CoA reductase, trans-2-enoyl-CoA reductase (NADPH)
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Reference on EC 1.3.1.38 - trans-2-enoyl-CoA reductase (NADPH)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nishimaki, T.; Yamanaka, H.; Mizugaki, M.
Studies on the metabolism of unsaturated fatty acids. XIV. Purification and properties of NADPH-dependent trans-2-enoyl-CoA reductase of Escherichia coli K-12
J. Biochem.
95
1315-1321
1984
Escherichia coli
Mizugaki, M.; Nishimaki, T.; Shiraishi, T.; Yamanaka, H.
Studies on the metabolism of unsaturated fatty acids. VII. Separation and general properties of reduced nicotinamide adenine dinucleotide phosphate-dependent trans-2-enoyl-coenzyme A reductase from Escherichia coli K-12
Chem. Pharm. Bull.
30
2503-2511
1982
Escherichia coli
Mizugaki, M.; Nishimaki, T.; Shiraishi, T.; Kawaguchi, A.; Okuda, S.; Yamanaka, H.
Studies on the metabolism of unsaturated fatty acids. IX. Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli
J. Biochem.
92
1649-1654
1982
Escherichia coli
Bernert, J.T.; Sprecher, H.
An analysis of partial reactions in the overall chain elongation of saturated and unsaturated fatty acids by rat liver microsomes
J. Biol. Chem.
252
6736-6744
1977
Rattus norvegicus
Bernert, J.T.; Sprecher, H.
The isolation of acyl-CoA derivatives as products of partial reactions in the microsomal chain elongation of fatty acids
Biochim. Biophys. Acta
573
436-442
1979
Rattus norvegicus
Prasad, M.R.; Chiang, C.F.; Cook, L.; Cinti, D.L.
Solubilization and purification of hepatic microsomal trans-2-enoyl-CoA reductase: evidence for the existence of a second long-chain enoyl-CoA reductase
Arch. Biochem. Biophys.
237
535-544
1985
Rattus norvegicus
Nagi, M.N.; Prasad, M.R.; Cook, L.; Cinti, D.
Biochemical properties of short- and long-chain rat liver microsomal trans-2-enoyl coenzyme A reductase
Arch. Biochem. Biophys.
226
50-64
1983
Rattus norvegicus
Prasad, M.R.; Nagi, M.N.; Cook, L.; Cinti, D.L.
Kinetic evidence for two separate trans-2-enoyl CoA reductases in rat hepatic microsomes: NADPH-specific short chain- and NAD(P)H-dependent long chain-reductase
Biochem. Biophys. Res. Commun.
113
659-665
1983
Rattus norvegicus
Cinti, D.L.; Nagi, M.N.; Cook, L.; White, R.E.
Evidence for a second microsomal trans-2-enoyl coenzyme A reductase in rat liver. NADPH-specific short chain reductase
J. Biol. Chem.
257
14333-14340
1982
Rattus norvegicus
Nagi, M.N.; Cook, L.; Ghesquier, D.; Cinti, D.L.
Site of inhibition of rat liver microsomal fatty acid chain elongation system by dec-2-ynoyl coenzyme A. Possible mechanism of inhibition
J. Biol. Chem.
261
13598-13605
1986
Rattus norvegicus
Nagi, M.N.; Cook, L.; Laguna, J.C.; Cinti, D.L.
Dual action of 2-decynoyl coenzyme A: inhibitor of hepatic mitochondrial trans-2-enoyl coenzyme A reductase and peroxisomal bifunctional protein and substrate for the mitochondrial beta-oxidation system
Arch. Biochem. Biophys.
267
1-12
1988
Rattus norvegicus
Laguna, J.C.; Nagi, M.; Cook, L.; Cinti, D.L.
Action of Ebselen on rat hepatic microsomal enzyme-catalyzed fatty acid chain elongation, desaturation, and drug biotransformation
Arch. Biochem. Biophys.
269
272-283
1989
Rattus norvegicus
Das, A.K.; Uhler, M.D.; Hajra, A.K.
Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs
J. Biol. Chem.
275
24333-24340
2000
Mus musculus (Q99MZ7), Mus musculus, Homo sapiens (Q9BY49), Homo sapiens, Cavia porcellus (Q9JIF5), Cavia porcellus
Reynolds, K.A.
Comparison of two unusual enoyl-CoA reductases in Streptomyces collinus
J. Nat. Prod.
56
175-185
1993
Streptomyces collinus
-
Moon, Y.A.; Horton, J.D.
Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade
J. Biol. Chem.
278
7335-7343
2003
Homo sapiens, Mus musculus (Q9CY27)
Poletto, S.S.; da Fonseca, I.O.; de Carvalho, L.P.; Basso, L.A.; Santos, D.S.
Selection of an Escherichia coli host that expresses mutant forms of Mycobacterium tuberculosis 2-trans enoyl-ACP(CoA) reductase and 3-ketoacyl-ACP(CoA) reductase enzymes
Protein Expr. Purif.
34
118-125
2004
Mycobacterium tuberculosis
Gloerich, J.; Ruiter, J.P.; van den Brink, D.M.; Ofman, R.; Ferdinandusse, S.; Wanders, R.J.
Peroxisomal trans-2-enoyl-CoA reductase is involved in phytol degradation
FEBS Lett.
580
2092-2096
2006
Homo sapiens
Bell, A.F.; Stratton, C.F.; Zhang, X.; Novichenok, P.; Jaye, A.A.; Nair, P.A.; Parikh, S.; Rawat, R.; Tonge, P.J.
Evidence from Raman spectroscopy that InhA, the mycobacterial enoyl reductase, modulates the conformation of the NADH cofactor to promote catalysis
J. Am. Chem. Soc.
129
6425-6431
2007
Mycobacterium tuberculosis
Song, W.Q.; Qin, Y.M.; Saito, M.; Shirai, T.; Pujol, F.M.; Kastaniotis, A.J.; Hiltunen, J.K.; Zhu, Y.X.
Characterization of two cotton cDNAs encoding trans-2-enoyl-CoA reductase reveals a putative novel NADPH-binding motif
J. Exp. Bot.
60
1839-1848
2009
Gossypium hirsutum (A9XUG7), Gossypium hirsutum (A9XUG8), Gossypium hirsutum
Gurvitz, A.
A C. elegans model for mitochondrial fatty acid synthase II: the longevity-associated gene W09H1.5/mecr-1 encodes a 2-trans-enoyl-thioester reductase
PLoS ONE
4
e7791
2009
Caenorhabditis elegans (O45903), Caenorhabditis elegans (Q9XXC8), Caenorhabditis elegans
Fu, S.F.; Tsai, T.M.; Chen, Y.R.; Liu, C.P.; Haiso, L.J.; Syue, L.H.; Yeh, H.H.; Huang, H.J.
Characterization of the early response of the orchid, Phalaenopsis amabilis, to Erwinia chrysanthemi infection using expression profiling
Physiol. Plant.
145
406-425
2012
Phalaenopsis amabilis
Kim, D.G.; Yoo, J.C.; Kim, E.; Lee, Y.S.; Yarishkin, O.V.; Lee, D.Y.; Lee, K.H.; Hong, S.G.; Hwang, E.M.; Park, J.Y.
A novel cytosolic isoform of mitochondrial trans-2-enoyl-CoA reductase enhances peroxisome proliferator-activated receptor alpha activity
Endocrinol. Metab. (Seoul)
29
185-194
2014
Rattus norvegicus
Abe, K.; Ohno, Y.; Sassa, T.; Taguchi, R.; Caliskan, M.; Ober, C.; Kihara, A.
Mutation for nonsyndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability, leading to change in sphingolipid profile
J. Biol. Chem.
288
36741-36749
2013
Homo sapiens
Wakashima, T.; Abe, K.; Kihara, A.
Dual functions of the trans-2-enoyl-CoA reductase TER in the sphingosine 1-phosphate metabolic pathway and in fatty acid elongation
J. Biol. Chem.
289
24736-24748
2014
Homo sapiens
Tomiyama, T.; Goto, K.; Tanaka, Y.; Maruta, T.; Ogawa, T.; Sawa, Y.; Ito, T.; Ishikawa, T.
A major isoform of mitochondrial trans-2-enoyl-CoA reductase is dispensable for wax ester production in Euglena gracilis under anaerobic conditions
PLoS ONE
14
e0210755
2019
Euglena gracilis (Q5EU90), Euglena gracilis
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