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17alpha-hydroxyprogesterone + NADPH
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2-cyclohexen-1-one + NADPH + H+
cyclohexanone + NADP+
4-androstene-3,17-dione + NADPH
5beta-androstan-3,17-dione + NADP+
aldosterone + NADPH
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low activity
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-
?
cholest-4-en-3-one + NADPH + H+
5beta-cholestan-3-one + NADP+
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corticosterone + NADPH + H+
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low activity
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-
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cortisol + NADPH
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very low activity
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?
cortisone + NADPH + H+
17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+
DELTA 4-cholestene-7alpha,12alpha-diol-3-one + NADPH + H+
5beta-cholestane-7alpha,12alpha-diol-3-one + NADP+
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a bile acid intermediate
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?
DELTA4-cholesten-7alpha-ol-3-one + NADPH + H+
5beta-cholestan-7alpha-ol-3-one + NADP+
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a bile acid intermediate
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progesterone + NADPH
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?
progesterone + NADPH + H+
5beta-pregnane-3,20-dione + NADP+
progesterone + NADPH + H+
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?
testosterone + NADPH + H+
(5beta,17beta)-17-hydroxyandrostan-3-one + NADP+
testosterone + NADPH + H+
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additional information
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2-cyclohexen-1-one + NADPH + H+
cyclohexanone + NADP+
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?
2-cyclohexen-1-one + NADPH + H+
cyclohexanone + NADP+
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-
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?
4-androstene-3,17-dione + NADPH
5beta-androstan-3,17-dione + NADP+
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?
4-androstene-3,17-dione + NADPH
5beta-androstan-3,17-dione + NADP+
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?
cortisone + NADPH + H+
17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+
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?
cortisone + NADPH + H+
17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+
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-
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?
progesterone + NADPH + H+
5beta-pregnane-3,20-dione + NADP+
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?
progesterone + NADPH + H+
5beta-pregnane-3,20-dione + NADP+
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?
progesterone + NADPH + H+
5beta-pregnane-3,20-dione + NADP+
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stereospecific reduction of the 4-double-bond in cardenolide biosynthesis
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?
testosterone + NADPH + H+
(5beta,17beta)-17-hydroxyandrostan-3-one + NADP+
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testosterone + NADPH + H+
(5beta,17beta)-17-hydroxyandrostan-3-one + NADP+
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additional information
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AKR1D1 catalyzes the stereospecific reduction of the delta4-double-bond of circulating steroid hormones that contain the delta4-3-ketosteroid functionality, e.g. the reduction of testosteron, progesterone and cortisol to yield the corresponding 5-dihydrosteroid
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additional information
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aldo-keto reductases are a major superfamily of monomeric NADPH-dependent carbonyl oxidoreductases, active site contains conserved residues D50, Y55, K84, and H117
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additional information
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the steroid 5beta-reductases catalyze a reaction that is unique in steroid enzymology since the resultant product contains a cis-A/B ring configuration and accordingly contains a 90° bend, the cis-A/B ring configuration is an essential characteristic of cardiac glycosides, e.g. digioxin and bile acids and their precursors
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additional information
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AKR1D1 catalyzes the central 5beta-reduction step and reduces bile acid precursors such as DELTA4-cholesten-7alpha-ol-3-one and DELTA 4-cholestene-7alpha,12alpha-diol-3-one to 5beta-cholestan-7alpha-ol-3-one and 5beta-cholestane-7alpha,12alpha-diol-3-one, respectively
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additional information
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enzyme is involved in the biosynthesis of ecdysteroids, catalyzes the 5beta-reduction of a 3-oxo-DELTA4-diketol to a 3-oxo-5beta-diketol
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