1.3.1.24: biliverdin reductase

This is an abbreviated version!
For detailed information about biliverdin reductase, go to the full flat file.

Word Map on EC 1.3.1.24

1.3.1.24

heme

oxygenase-1

monoxide

cytoprotective

repolarization

beat-to-beat

rosenthal

hyperbilirubinemia

palliation

tetrapyrrole

tdp

torsades

diagnostics

proarrhythmia

medicine

galenic

univentricular

pharmacology

Reaction

Synonyms

biliverdin IXalpha reductase, biliverdin IXbeta reductase, biliverdin reductase, biliverdin reductase A, biliverdin reductase B, Biliverdin reductase-A, biliverdin-IXalpha reductase, BLVR subtype B, BLVRA, BLVRB, BV reductase, BVR, BVR-A, BVR-B, BVRA, BVRB, F-BVR, F420H2-dependent biliverdin reductase, hBVR, hBVR-A, reductase, biliverdin, Rv2074, slr1784

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.24 biliverdin reductase

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Results	in table
19	Activating Compound
243	AA Sequence
16	Application
1	CAS Registry Number
28	Cloned(Commentary)
150	Cofactor
9	Crystallization (Commentary)
355	Disease/ Diagnostics
25	Expression
39	General Information
4	General Stability
73	Inhibitors
20	kcat/KM [mM/s]
12	Ki Value [mM]
70	KM Value [mM]
37	Localization
6	Metals/Ions
41	Molecular Weight [Da]
76	Natural Substrates/ Products (Substrates)
322	Organism
6	Pathway
37	PDB ID
36	pH Optimum
1	pH Range
1	pH Stability
7	Posttranslational Modification
49	Protein Variants
26	Purification (Commentary)
3	Reaction
19	Reaction Type
130	Reference
145	Source Tissue
6	Specific Activity [micromol/min/mg]
7	Storage Stability
154	Substrates and Products (Substrate)
21	Subunits
122	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
26	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.3.1.24 - biliverdin reductase

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5,5'-dithiobis(2-nitrobenzoate)

albumin

Arsenobenzoate

1 mM, slight

bilirubin

Biliverdin

biliverdin IXalpha

with cofactor NADPH, inhibitory above 0.004 mM, with cofactor NADH, inhibitory above 0.018 mM

654781

Ca2+

Homo sapiens

abolishes autophosphorylation of BVR

CuSO4

Dithionitrobenzoate

FAD

Fe2+

Fe3+

FMN

GATA1

transcription factor GATA1 downregulates BVR expression

Hematin

HgCl2

irreversible inhibition

iodoacetamide

iodoacetate

Iron-hematoporphyrin

competitive, acts as biliverdin-bilirubin analog

437796

lipase

Cavia porcellus

437808

Metalloporphyrin complexes

Rattus norvegicus

437789

Mg2+

Homo sapiens

abolishes autophosphorylation of BVR

N-ethylmaleimide

NAD+

NADH

at pH 8.5, competitive to NADPH

437798

NADP+

3 entries

NADPH

Bos taurus

at pH 7.0, competitive to NADH

437798

p-chloromercuribenzoate

6 entries

p-hydroxymercuribenzoate

Cavia porcellus

437808

potato acid phosphatase

Homo sapiens

human bilverdin reductase expressed in E. coli

437809

Protein phosphatase 2A

Homo sapiens

human bilverdin reductase expressed in E. coli, okadaic acid attenuates the inhibition

437809

SH-reactive agent

Rattus norvegicus

34000 Da form extremely sensitive to, larger 68000 Da form lacks sensitivity to

SH-reagents

siRNA

Trypsin

zinc-protoporphyrin

Zn2+

inhibitory to autophosphorylation of BVR, can not be overcome with Mn2+

666747

additional information

Homo sapiens

since no specific inhibitors for BVR are known, siRNA is used to silence the BVR gene in primary endothelial cells and accordingly suppress its activity

712793