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1.3.1.2: dihydropyrimidine dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about dihydropyrimidine dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.3.1.2

Reaction

5,6-dihydrouracil
+
NADP+
=
Uracil
+
NADPH
+
H+

Synonyms

4,5-dihydrothymine: oxidoreductase, dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate), DHPDH, DHPDHase, DHU dehydrogenase, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, dihydrouracil dehydrogenase (NADP), dihydrouracil dehydrogenase (NADP+), DPD, DPYD, hydropyrimidine dehydrogenase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.2 dihydropyrimidine dehydrogenase (NADP+)

Storage Stability

Storage Stability on EC 1.3.1.2 - dihydropyrimidine dehydrogenase (NADP+)

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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-15°C, 20% loss of activity after 1 month
-
-20°C, 2 mg/ml protein, 10% loss of activity after 2 weeks
-
-20°C, protein concentration 0.5-1 mg/ml, 1 mM dithiothreitol, stable for several months
-
-80°C, 35 mM potassium phosphate, pH 7.4, 1 mM dithioerythritol, more than 2 months without loss of activity, without dithioerythritol 50% loss of activity
-