1.3.1.2: dihydropyrimidine dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about dihydropyrimidine dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.3.1.2
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1.3.1.2
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5-fluorouracil
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thymidine
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phosphorylase
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uridine
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medicine
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phosphoribosyltransferase
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orotate
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2.4.2.4
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thymidylate
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fluoropyrimidine
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fdurd
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2.7.1.21
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beta-ureidopropionase
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urdpase
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dihydropyrimidinase
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beta-alanine
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drug development
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analysis
- 1.3.1.2
- 5-fluorouracil
- thymidine
- phosphorylase
- uridine
- medicine
-
phosphoribosyltransferase
- orotate
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2.4.2.4
- thymidylate
-
fluoropyrimidine
-
fdurd
-
2.7.1.21
- beta-ureidopropionase
- urdpase
- dihydropyrimidinase
- beta-alanine
- drug development
- analysis
Reaction
Synonyms
4,5-dihydrothymine: oxidoreductase, dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate), DHPDH, DHPDHase, DHU dehydrogenase, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, dihydrouracil dehydrogenase (NADP), dihydrouracil dehydrogenase (NADP+), DPD, DPYD, hydropyrimidine dehydrogenase
ECTree
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Reaction
Reaction on EC 1.3.1.2 - dihydropyrimidine dehydrogenase (NADP+)
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abstraction of pro-S hydrogen of NADPH and thus B-side stereospecific class dehydrogenase
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5,6-dihydrouracil + NADP+ = uracil + NADPH + H+
abstraction of pro-S hydrogen of NADPH and thus B-side stereospecific class dehydrogenase
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5,6-dihydrouracil + NADP+ = uracil + NADPH + H+
random rapid-equilibrium mechanism
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5,6-dihydrouracil + NADP+ = uracil + NADPH + H+
mechanism, rate-determining half-reaction for reduction of flavin by NADPH has minor rate limitation, while the following protonation of flavin at N-1 is slow
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5,6-dihydrouracil + NADP+ = uracil + NADPH + H+
nonclassical ping-pong mechanism
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5,6-dihydrouracil + NADP+ = uracil + NADPH + H+
comparison of substrate and cofactor binding to wild-type and mutant enzyme
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