1.3.1.2: dihydropyrimidine dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about dihydropyrimidine dehydrogenase (NADP+), go to the full flat file.
Word Map on EC 1.3.1.2
-
1.3.1.2
-
5-fluorouracil
-
thymidine
-
phosphorylase
-
uridine
-
medicine
-
phosphoribosyltransferase
-
orotate
-
2.4.2.4
-
thymidylate
-
fluoropyrimidine
-
fdurd
-
2.7.1.21
-
beta-ureidopropionase
-
urdpase
-
dihydropyrimidinase
-
beta-alanine
-
drug development
-
analysis
- 1.3.1.2
- 5-fluorouracil
- thymidine
- phosphorylase
- uridine
- medicine
-
phosphoribosyltransferase
- orotate
-
2.4.2.4
- thymidylate
-
fluoropyrimidine
-
fdurd
-
2.7.1.21
- beta-ureidopropionase
- urdpase
- dihydropyrimidinase
- beta-alanine
- drug development
- analysis
Reaction
Synonyms
4,5-dihydrothymine: oxidoreductase, dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate), DHPDH, DHPDHase, DHU dehydrogenase, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, Dihydrouracil dehydrogenase, dihydrouracil dehydrogenase (NADP), dihydrouracil dehydrogenase (NADP+), DPD, DPYD, hydropyrimidine dehydrogenase
ECTree
Advanced search results
Inhibitors
Inhibitors on EC 1.3.1.2 - dihydropyrimidine dehydrogenase (NADP+)
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
chloramphenicol
-
2.0fold reduced activity in chloramphenicol-treated cells
-
50% inhibition at 0.01 mM, no inhibition by free base
(E)-5-[2-bromovinyl-]uracil
-
50% inhibition at 0.01 mM, no inhibition by free base
5-Ethynyluracil
covalently inactivates DPD by cross-linking with the active-site general acid cysteine in the pyrimidine binding site. This reaction is dependent on the simultaneous binding of 5-ethynyluracil and NADPH. The ternary complex induces DPD to become activated by taking up two electrons from the NADPH. The covalent inactivation of DPD by 5-ethynyluracil occurs concomitantly with this reductive activation with a rate constant of about 0.2 per s. This kinact value is correlated with the rate of reduction of one of the two flavin cofactors and the localization of a mobile loop in the pyrimidine active site
-
no inhibition or inactivation with 5-nitro-, 5-fluoro-,5-carbamido-, 5-formyl-, 5-acetamido-, 5-hydroxymethyl- or 5-chlorouracil
-
additional information
-
no inhibition or inactivation with 5-nitro-, 5-fluoro-,5-carbamido-, 5-formyl-, 5-acetamido-, 5-hydroxymethyl- or 5-chlorouracil
-
additional information
-
no inhibition or inactivation with 5-nitro-, 5-fluoro-,5-carbamido-, 5-formyl-, 5-acetamido-, 5-hydroxymethyl- or 5-chlorouracil
-
additional information
-
no inhibition or inactivation with 5-nitro-, 5-fluoro-,5-carbamido-, 5-formyl-, 5-acetamido-, 5-hydroxymethyl- or 5-chlorouracil
-