1.3.1.14: dihydroorotate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.3.1.14

1.3.1.14

pyrimidine

flavin

brequinar

medicine

l-dihydroorotate

fmn

lactis

o2-sensitive

mononucleotide

photons

bifidobacterium

bifidum

berghei

ubiquinone

carbamyl

half-reaction

nutrition

pharmacology

1.3.3.1

Reaction

Synonyms

b-type dihydroorotate dehydrogenase, DHO dehydrogenase, DHODase, DHOdehase A, dihydro-orotic dehydrogenase, dihydroorotate dehydrogenase, dihydrorotate dehydrogenase B, L-5,6-dihydro-orotate:NAD oxidoreductase, More, orotate reductase, reductase, orotate

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.14 dihydroorotate dehydrogenase (NAD+)

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Results	in table
14	Activating Compound
824	AA Sequence
7	Application
1	CAS Registry Number
6	Cloned(Commentary)
67	Cofactor
2	Crystallization (Commentary)
1	General Stability
32	Inhibitors
11	Ki Value [mM]
19	KM Value [mM]
8	Localization
19	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
24	Organism
5	Pathway
4	PDB ID
6	pH Optimum
4	pH Range
2	pH Stability
9	Protein Variants
9	Purification (Commentary)
9	Reaction
4	Reaction Type
22	Reference
2	Renatured (Commentary)
9	Specific Activity [micromol/min/mg]
7	Storage Stability
54	Substrates and Products (Substrate)
14	Subunits
14	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
15	Turnover Number [1/s]

KM Value

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KM Value on EC 1.3.1.14 - dihydroorotate dehydrogenase (NAD+)

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0.044 - 0.367

(S)-dihydroorotate

5 entries

0.13

5-Fluoroorotate

Faecalicatena orotica

390561, 390564

0.09

L-dihydroorotate

Faecalicatena orotica

pH 8, 25°C

390568

0.062 - 0.13

NAD+

2 entries

0.0037

NADH

Lactococcus lactis

wild-type enzyme

674586

0.0144 - 0.13

Orotate

4 entries

0.027 - 1

S-dihydroorotate

3 entries