1.3.1.14: dihydroorotate dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (NAD+), go to the full flat file.
Word Map on EC 1.3.1.14
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1.3.1.14
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pyrimidine
-
flavin
-
brequinar
-
medicine
-
l-dihydroorotate
-
fmn
-
lactis
-
o2-sensitive
-
mononucleotide
-
photons
-
bifidobacterium
-
bifidum
-
berghei
-
ubiquinone
-
carbamyl
-
half-reaction
-
nutrition
-
pharmacology
-
1.3.3.1
- 1.3.1.14
- pyrimidine
- flavin
- brequinar
- medicine
- l-dihydroorotate
- fmn
- lactis
-
o2-sensitive
- mononucleotide
-
photons
- bifidobacterium
- bifidum
- berghei
- ubiquinone
-
carbamyl
-
half-reaction
- nutrition
- pharmacology
-
1.3.3.1
Reaction
Synonyms
b-type dihydroorotate dehydrogenase, DHO dehydrogenase, DHODase, DHOdehase A, dihydro-orotic dehydrogenase, dihydroorotate dehydrogenase, dihydrorotate dehydrogenase B, L-5,6-dihydro-orotate:NAD oxidoreductase, More, orotate reductase, reductase, orotate
ECTree
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Inhibitors
Inhibitors on EC 1.3.1.14 - dihydroorotate dehydrogenase (NAD+)
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(S,S)-N-(1-carboxyethyl)-N'-(1-carboxy-2-phenylethyl)urea
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4 mM, 20% inhibition
5-Benzyl-3-(1-carboxy-2-phenylethyl)hydantoin
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time-dependent irreversible inhibition at the active site, mechanism
Hg2+
complete inhibition of both orotate reductase and NADH oxidase reaction
hydantoin
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derived from alpha-amino acids, weak competitive inhibitors, compounds with a benzyl goup are better inhibitors
complete inhibition of both orotate reductase and NADH oxidase reaction