1.3.1.14: dihydroorotate dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about dihydroorotate dehydrogenase (NAD+), go to the full flat file.
Word Map on EC 1.3.1.14
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1.3.1.14
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pyrimidine
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flavin
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brequinar
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medicine
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l-dihydroorotate
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fmn
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lactis
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o2-sensitive
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mononucleotide
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photons
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bifidobacterium
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bifidum
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berghei
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ubiquinone
-
carbamyl
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half-reaction
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nutrition
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pharmacology
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1.3.3.1
- 1.3.1.14
- pyrimidine
- flavin
- brequinar
- medicine
- l-dihydroorotate
- fmn
- lactis
-
o2-sensitive
- mononucleotide
-
photons
- bifidobacterium
- bifidum
- berghei
- ubiquinone
-
carbamyl
-
half-reaction
- nutrition
- pharmacology
-
1.3.3.1
Reaction
Synonyms
b-type dihydroorotate dehydrogenase, DHO dehydrogenase, DHODase, DHOdehase A, dihydro-orotic dehydrogenase, dihydroorotate dehydrogenase, dihydrorotate dehydrogenase B, L-5,6-dihydro-orotate:NAD oxidoreductase, More, orotate reductase, reductase, orotate
ECTree
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Activating Compound
Activating Compound on EC 1.3.1.14 - dihydroorotate dehydrogenase (NAD+)
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cysteine
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essential for assay, interaction of enzyme with orotate or dihydroorotate is dependent on cysteine, whereas NADH oxidase activity is not
cysteine
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required for activation of purified enzyme, but not if crude extract is used for assay
cysteine
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L-cysteine activates strongly, D-cysteine is also an activator, 1.8 mM L-cysteine is required at pH 8 for half-maximal activity, 10 mM for near-maximal activity
cysteine
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reaction rate increases 2fold in the presence of 2-7 mM cysteine
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thiol activation involves reduction of side chain of a cysteine residue corresponding to Cys-130, which functions as a general base
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