1.3.1.12: prephenate dehydrogenase

This is an abbreviated version!
For detailed information about prephenate dehydrogenase, go to the full flat file.

Word Map on EC 1.3.1.12

1.3.1.12

l-tyrosine

h-protein

arogenate

hyperglycinemia

nonketotic

4-hydroxyphenylpyruvate

aminomethyltransferase

dahp

3-deoxy-d-arabino-heptulosonate

cyclohexadienyl

7-phosphate

dimethylglycine

tetrahydrofolate-dependent

glycine-cleavage

aminomethyl

folate-binding

Reaction

Synonyms

AceF, AroQ, bifunctional T-protein, chorismate mutase-prephenate dehydratase, chorismate mutase-prephenate dehydrogenase bifunctional enzyme, chorismate mutase-T:prephenate dehydrogenase bifunctional enzyme, Chorismate mutase/prephenate dehydratase, CM-PD, CM-TyrAp, CM/PDT/PDHG, CMPD, dehydrogenase, prephenate, hydroxyphenylpyruvate synthase, PD, PDH, pdhE-1, PDHG, T-protein, TYR1, tyrA, TyrA dehydrogenase, TyrAp

ECTree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.1 With NAD⁺ or NADP⁺ as acceptor

1.3.1.12 prephenate dehydrogenase

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Results	in table
8	Activating Compound
11849	AA Sequence
2	Application
3	CAS Registry Number
21	Cloned(Commentary)
37	Cofactor
5	Crystallization (Commentary)
4	General Information
21	General Stability
1	IC50 Value
105	Inhibitors
7	kcat/KM [mM/s]
26	Ki Value [mM]
82	KM Value [mM]
6	Metals/Ions
33	Molecular Weight [Da]
60	Natural Substrates/ Products (Substrates)
277	Organism
8	Pathway
21	PDB ID
11	pH Optimum
3	pH Range
1	pI Value
1	Posttranslational Modification
18	Protein Variants
36	Purification (Commentary)
3	Reaction
4	Reaction Type
80	Reference
29	Specific Activity [micromol/min/mg]
13	Storage Stability
140	Substrates and Products (Substrate)
18	Subunits
79	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
4	Temperature Range [°C]
6	Temperature Stability [°C]
51	Turnover Number [1/s]

General Stability

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General Stability on EC 1.3.1.12 - prephenate dehydrogenase

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bovine serum albumin, bovine casein or prephenate stabilizes

citrate stabilizes

dialysis inactivates

dithiothreitol stabilizes

EDTA stabilizes

glycerol stabilizes

NAD+ plus tyrosine stabilizes

Escherichia coli

3557

purified enzyme and diluted solution is unstable

Escherichia coli

390530

stability in Tris-HCl buffer higher than in phosphate buffer

thiols stabilize

tyrosine stabilizes

unstable in buffers of low ionic strength lacking glycerol

Escherichia coli

390522

unstable in crude extracts

Pseudomonas aeruginosa

390535