1.3.1.104: enoyl-[acyl-carrier-protein] reductase (NADPH)
This is an abbreviated version!
For detailed information about enoyl-[acyl-carrier-protein] reductase (NADPH), go to the full flat file.
Reaction
Synonyms
enoyl-ACP reductase, enoyl-acyl carrier protein reductase, enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate) reductase, ENR, ETR1, FabI, FabL, Fabl2, JamJ, NADPH 2-enoyl Co A reductase, NWMN_0881, YgaA
ECTree
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Inhibitors
Inhibitors on EC 1.3.1.104 - enoyl-[acyl-carrier-protein] reductase (NADPH)
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AFN-1252
antibiotic AFN-1252, i.e. (2E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)prop-2-enamide, only binds to the NADPH form of FabI
enzyme is reversibly inhibited by triclosan, but does not form a stable ternary complex
triclosan
the introduction of a plasmid expressing the enzyme gene leads to triclosan resistance