1.3.1.101: 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]
This is an abbreviated version!
For detailed information about 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], go to the full flat file.
Reaction
+ 8 NAD(P)+ = + 8 NAD(P)H + 8 H+
Synonyms
2,3-digeranylgeranylglycerophospholipid reductase, DGGGPL reductase, digeranylgeranylglycerophospholipid reductase, Ta0516m
ECTree
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Cofactor
Cofactor on EC 1.3.1.101 - 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H]
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FAD
the sequence PxxYxWxFP defines a specificity pocket in the enzyme and precisely aligns the double bond of the geranyl group with respect to the FAD cofactor, thus providing a structural basis for the substrate specificity of geranylgeranyl reductases. FAD switches between two conformations that correspond to the reductive and oxidative half cycles. The structure provides evidence that substrate binding likely involves conformational changes, which are coupled to the two conformational states of the FAD