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1.3.1.10: enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)

This is an abbreviated version!
For detailed information about enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific), go to the full flat file.

Word Map on EC 1.3.1.10

Reaction

acyl-[acyl-carrier protein]
+
NADP+
=
trans-2,3-dehydroacyl-[acyl-carrier protein]
+
NADPH
+
H+

Synonyms

1-cyclohexenylcarbonyl coenzyme A reductase, 2-enoyl thioester reductase, 2-trans-enoyl-ACP reductase, acyl-ACP dehydrogenase, beta-ketoacyl reductase, enoyl acyl-carrier-protein reductase, enoyl reductase, enoyl thioester reductase, enoyl-ACP reductase, enoyl-ACP reductase II, enoyl-ACP reductase III, enoyl-ACP-reductase II, enoyl-acyl carrier protein reductase, enoyl-[acyl carrier protein] reductase, enoyl-[acyl-carrier-protein] reductase, ENR, Etr1p, fabG4, FabI, FabK, FabL, Fabl2, More, Mrf1p, NADPH 2-enoyl Co A reductase, reductase, enoyl-[acyl carrier protein] (reduced nicotinamide adenine dinucleotide phosphate), trans-enoyl-[acyl-carrier-protein] reductase, YgaA

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.1 With NAD+ or NADP+ as acceptor
                1.3.1.10 enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)

Inhibitors

Inhibitors on EC 1.3.1.10 - enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(E)-N-(1,2-dimethyl-1H-indol-3-ylmethyl)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
-
5-chloro-2-phenoxyphenol
-
-
5-ethyl-2-phenoxyphenol
-
-
6-methyl-2-(propane-1-sulfonyl)-4a,7a-dihydro-2H-thieno[3,2-d][1,2,3]diazaborinin-1-ol
-
diazaborine derivative 2b18, binds only in presence of NADH or NADPH, non-competitive inhibition, 0.2 mM lead to 25% inhibition, 0.52 mM to 50%, 1.56 mM to 80%. Increasing the inhibitor concentrations lead to preference for shorter acyl chain lengths
aquastatin A
-
a natural inhibitor from the fungus Sporothrix sp. strain FN611, mixed-type inhibition against FabI with respect to the substrate trans-2-octenoyl N-acetylcysteamine and NADPH, prevents the growth of Staphylococcus aureus and methicillin-resistant Staphylococcus aureus with minimum inhibitory concentration of 0.016-0.032 mg/ml, overview
degalactosylated aquastatin A
-
a natural inhibitor from the fungus Sporothrix sp. strain FN611
Hexachlorophene
half-maximal inhibition at 0.004 mM
iodoacetate
-
-
N-ethylmaleimide
-
-
p-hydroxymercuribenzoate
-
-
palmitoyl-CoA
-
0.0016 mM lead to 50% inhibition, 0.002 mM to 60%, 0.005 mM to 20%, 0.01 mM to nearly total inhibition
triclosan
additional information
-