1.3.1.1: dihydropyrimidine dehydrogenase (NAD+)

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For detailed information about dihydropyrimidine dehydrogenase (NAD+), go to the full flat file.

Reaction

Synonyms

dehydrogenase, dihydrouracil, dihydropyrimidine dehydrogenase, dihydrothymine dehydrogenase, dihydrouracil dehydrogenase (NAD+), DPD, pyrimidine deaminase/reductase, pyrimidine reductase, RibD, thymine reductase, uracil reductase

ECTree

     1 Oxidoreductases

         1.3 Acting on the CH-CH group of donors

             1.3.1 With NAD⁺ or NADP⁺ as acceptor

                1.3.1.1 dihydropyrimidine dehydrogenase (NAD+)

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Results	in table
5	Activating Compound
737	AA Sequence
5	Application
1	CAS Registry Number
1	Cloned(Commentary)
23	Cofactor
1	Crystallization (Commentary)
4	Disease/ Diagnostics
2	Expression
3	General Information
7	Inhibitors
4	kcat/KM [mM/s]
4	KM Value [mM]
4	Localization
5	Molecular Weight [Da]
12	Natural Substrates/ Products (Substrates)
42	Organism
4	Pathway
4	pH Optimum
1	pH Range
2	Protein Variants
3	Purification (Commentary)
2	Reaction
3	Reaction Type
30	Reference
39	Source Tissue
8	Specific Activity [micromol/min/mg]
38	Substrates and Products (Substrate)
2	Subunits
49	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
4	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.3.1.1 - dihydropyrimidine dehydrogenase (NAD+)

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

5-chloro-2,4-dihydroxypyridine

Homo sapiens

-

potent inhibitor

685782

cisplatin

Homo sapiens

-

cell lines CAL 27, CAL 33, CAL 51, PANC 3

349142

dipyridamole

Homo sapiens

-

cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3, mechanism

349142

Hydroxyurea

Homo sapiens

-

cell lines CAL 27, CAL 33, CAL 51, ORL 1, PANC 3

349142

interferon-alpha-2a

Homo sapiens

-

cell lines CAL 27, CAL 33, CAL 51, CAL 7, PANC 3

349143

-

Uracil

Homo sapiens

-

reversible inhibition

686102

additional information

Homo sapiens

-

combined oral treatment with uracil and tegafur has no influence on DPD activity

686102

-