1.21.99.3: thyroxine 5-deiodinase
This is an abbreviated version!
For detailed information about thyroxine 5-deiodinase, go to the full flat file.
Word Map on EC 1.21.99.3
-
1.21.99.3
-
thyroid
-
triiodothyronine
-
hypothyroidism
-
tsh
-
deiodination
-
pituitary
-
euthyroidism
-
3,5,3'-triiodothyronine
-
adipose
-
5'-deiodination
-
propylthiouracil
-
l-thyroxine
-
prohormone
-
3,3',5'-triiodothyronine
-
thyrotropin
-
selenocysteine
-
selenoproteins
-
selenoenzyme
-
iopanoic
-
methimazole
-
dlk1-dio3
-
pituitary-thyroid
-
3,3'-diiodothyronine
-
medicine
-
monodeiodination
-
extrathyroidal
-
se-deficient
-
t3-dependent
-
selenium-deficient
-
hypothalamic-pituitary-thyroid
-
amiodarone
-
thyroidectomized
-
harderian
-
nonthyroidal
-
thyroxine-binding
-
thyrotropin-releasing
-
thermogenic
-
thyromimetically
-
inner-ring
-
6-n-propyl-2-thiouracil
-
thyroid-stimulating
-
thyrotoxicosis
- 1.21.99.3
- thyroid
- triiodothyronine
- hypothyroidism
- tsh
-
deiodination
- pituitary
-
euthyroidism
- 3,5,3'-triiodothyronine
- adipose
-
5'-deiodination
- propylthiouracil
- l-thyroxine
-
prohormone
- 3,3',5'-triiodothyronine
- thyrotropin
- selenocysteine
-
selenoproteins
-
selenoenzyme
-
iopanoic
- methimazole
-
dlk1-dio3
-
pituitary-thyroid
- 3,3'-diiodothyronine
- medicine
-
monodeiodination
-
extrathyroidal
-
se-deficient
-
t3-dependent
-
selenium-deficient
-
hypothalamic-pituitary-thyroid
- amiodarone
-
thyroidectomized
-
harderian
-
nonthyroidal
-
thyroxine-binding
-
thyrotropin-releasing
-
thermogenic
-
thyromimetically
-
inner-ring
- 6-n-propyl-2-thiouracil
-
thyroid-stimulating
-
thyrotoxicosis
Reaction
Synonyms
5'-deiodinase, D3, deiodinase, deiodinase 3, deiodinase, thyroxine 5-, deiodinase-3, diiodothyronine 5'-deiodinase, Dio, Dio3, Dio3a, Dio3b, EC 1.97.1.11, ID-3, iodothyronine 5-deiodinase, iodothyronine deiodinase type III, iodothyronine inner ring monodeiodinase, iodothyronine monodeiodinase, ITHD, T4-5'-deiodinase, T4-5-deiodinase, thyroxine 5-deiodinase, type 3 deiodinase, type 3 iodothyronine 5-deiodinase, type 3 iodothyronine deiodinase, type III deiodinase, type III iodothyronine deiodinase, type-3 deiodinase, zD3
ECTree
1.21.99.3 thyroxine 5-deiodinaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 1.21.99.3 - thyroxine 5-deiodinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3,3',5'-triiodo-L-thyronine + reduced acceptor
3,3'-diiodo-L-thyronine + iodide + acceptor + H+
-
-
-
-
?
L-thyroxine + reduced acceptor
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
-
-
-
-
?
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
-
-
-
?
3,3',5'-triiodo-L-thyronine + iodide + acceptor + H+
L-thyroxine + reduced acceptor
-
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
hormonally inactive, i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
selenocysteine residue in the active site is essential for efficient inner ring deiodination
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
hormonally inactive, i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
isozyme type III
hormonally inactive, i.e. 3,3'-diiodo-L-thyronine
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
no detectable activity in vivo, isozyme type III
-
-
?
3,3',5-triiodo-L-thyronine + AH2
3,3'-diiodo-L-thyronine + iodide + A + H+
-
-
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive, enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
5-deiodinase activity
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
selenocysteine residue in the active site is absolutely essential for efficient inner ring deiodination
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
in pre- and prometamorphic tadpoles, undetectable during metamorphic climax
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
hormonally inactive
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
5-deiodinase activity
from microsomal enzyme complex, 3,3',5'-triiodo-L-thyronine is regulatory active
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5'-triiodo-L-thyronine + iodide + A + H+
-
enzyme III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine
hormonally inactive
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
isozyme type III
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
in vivo after entering metamorphic climax, low 5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
-
?
L-thyroxine + AH2
3,3',5-triiodo-L-thyronine + iodide + A + H+
-
5'-deiodinase activity
from microsomal enzyme complex, 3,3',5-triiodo-L-thyronine is thyromimetically active
?
additional information
?
-
-
enzyme performs inactivation of thyroid hormones
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
thyroid hormone is essential for maintaining normal neurological functions both during development and in adult life
-
-
?
additional information
?
-
-
the enzyme is the major physiological inactivator of thyroid hormone. The presence of the enzyme at maternal-fetal interfaces is consistent with its role in modulating the thyroid status of the human fetus and its expression in endometrium suggests that local regulation of thyroid status is important in implantation
-
-
?
additional information
?
-
-
isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
additional information
?
-
-
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
-
-
?
additional information
?
-
-
enzyme activity is developmentally regulated, overview
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
additional information
?
-
-
thyronines and thyronamines are two groups of endogenous iodine-containing signaling molecules that are substrates of three deiodinase isozymes, which catalyze the sequential reductive removal of iodine from the respective precursor molecule. Development of a analytical method applying liquid chromatography/tandem mass spectrometry, overview
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
additional information
?
-
-
5-deiodinase activity in brain is slightly decreased in hypo- and slightly increased in hyperthyroidism
-
-
?
additional information
?
-
-
placental isozyme type III is only slightly increased in hyperthyroidism, while brain isozyme type III is strongly induced
-
-
?
additional information
?
-
-
enzyme performs inactivation of thyroid hormones
-
-
?
additional information
?
-
-
isozyme type III is a oncofetal enzyme, regulation
-
-
?
additional information
?
-
-
L-hormone analogues are preferentially deiodinated via the T4-5'-deiodination pathway, whereas D-analogues produce products via the T4-5-deiodination pathway
-
-
?
additional information
?
-
-
isozyme type III performs the inactivation of 3,3',5,5'-tetraiodo-L-thyronine and enzyme plays a critical role in regulating and maintaining the local 3,3',5-triiodo-L-thyronine content
-
-
?
