1.21.98.2: dichlorochromopyrrolate synthase

This is an abbreviated version!
For detailed information about dichlorochromopyrrolate synthase, go to the full flat file.

Reaction

2 3-(7-chloroindol-3-yl)-2-iminopropanoate +

+ 2 H2O

Synonyms

EC 1.21.3.9, EC 4.3.1.26, RebD

ECTree

1 Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.98 With other, known, physiological acceptors

1.21.98.2 dichlorochromopyrrolate synthase

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Results	in table
28	AA Sequence
4	Cloned(Commentary)
7	Cofactor
3	General Information
4	Metals/Ions
4	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
13	Organism
9	Pathway
1	pH Optimum
2	Purification (Commentary)
2	Reaction
7	Reference
26	Substrates and Products (Substrate)
4	Subunits
8	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Reference

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Reference on EC 1.21.98.2 - dichlorochromopyrrolate synthase

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696205

Howard-Jones, A.R.; Walsh, C.T.

Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD

Biochemistry

15652-15663

2005

Lentzea aerocolonigenes (Q8KHV6), Lentzea aerocolonigenes ATCC 39243 (Q8KHV6)

16313168

698454

Nishizawa, T.; Gr�schow, S.; Jayamaha, D.H.; Nishizawa-Harada, C.; Sherman, D.H.

Enzymatic assembly of the bis-indole core of rebeccamycin

J. Am. Chem. Soc.

128

724-725

2006

Lentzea aerocolonigenes (Q8KHV6), Lentzea aerocolonigenes ATCC 39243 (Q8KHV6)

16417354

702730

Onaka, H.; Taniguchi, S.; Igarashi, Y.; Furumai, T.

Characterization of the biosynthetic gene cluster of rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243

Biosci. Biotechnol. Biochem.

127-138

2003

Lentzea aerocolonigenes (Q8KHV6), Lentzea aerocolonigenes ATCC 39243 (Q8KHV6)

12619684

735561

Spolitak, T.; Ballou, D.P.

Evidence for catalytic intermediates involved in generating the chromopyrrolic acid scaffold of rebeccamycin by RebO and RebD

Arch. Biochem. Biophys.

573

111-119

2015

Streptomyces sp.

25837855