1.21.98.2: dichlorochromopyrrolate synthase

This is an abbreviated version!
For detailed information about dichlorochromopyrrolate synthase, go to the full flat file.

Reaction

2 3-(7-chloroindol-3-yl)-2-iminopropanoate +

+ 2 H2O

Synonyms

EC 1.21.3.9, EC 4.3.1.26, RebD

ECTree

1 Oxidoreductases

1.21 Catalysing the reaction X-H + Y-H = X-Y

1.21.98 With other, known, physiological acceptors

1.21.98.2 dichlorochromopyrrolate synthase

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28	AA Sequence
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3	General Information
4	Metals/Ions
4	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
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1	Temperature Optimum [°C]

Natural Substrates Products

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Natural Substrates Products on EC 1.21.98.2 - dichlorochromopyrrolate synthase

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2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2

dichlorochromopyrrolate + NH3 + 2 H2O

Streptomyces sp.

735561

4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2

2 dichlorochromopyrrolate + 2 NH3 + 2 H2O

2 entries

7-chloroindole-3-pyruvic acid + 7-chlorotryptophan + O2

11,11'-dichlorochromopyrrolic acid + NH3 + H2O

2 entries

additional information

Streptomyces sp.

RebD is a heme-containing peroxidase-like enzyme that catalyzes the oxidative linking of two tryptophan skeletons to form dichlorochromopyrrolic acid. RebD reacts as a peroxidase forming two indole-3-pyruvic acid imine radicals that recombine as a CC bond in the chromopyrrolic acid. When catalase is included to remove H2O2, chromopyrrolic acid can still be formed because the indole-3-pyruvic acid imine rapidly reduces RebD, which reacts with O2, utilizing oxidase-peroxidase chemistry to produce chromopyrrolic acid. Reduced RebD can also react with H2O2 forming Cpd II (state of a hemoprotein that is 1 equivalent of oxidation greater than the ferric form and contains an oxoferryl center) directly, which can oxidize indole-3-pyruvic acid imine. Competitng robust catalase activity of RebD

735561